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Tachykinin, Precursor 1 Proteins (TAC1)

TAC1 encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. Additionally we are shipping Tachykinin, Precursor 1 Antibodies (195) and Tachykinin, Precursor 1 Kits (119) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse TAC1 TAC1 21333 P41539
TAC1 6863 P20366
Rat TAC1 TAC1 24806 P06767
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Top Tachykinin, Precursor 1 Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 11 Days
HOST_Synthetic Synthetic Un-conjugated   5 mg Log in to see 11 to 16 Days
HOST_Synthetic Human Un-conjugated   100 μg Log in to see 11 to 13 Days
HOST_Synthetic Rabbit Un-conjugated   1 mg Log in to see 9 to 14 Days
HOST_Synthetic Pig Un-conjugated   1 mg Log in to see 9 to 14 Days

TAC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Top referenced Tachykinin, Precursor 1 Proteins

  1. Human TAC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098729 : Advenier, Lagente, Boichot: The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. in The European respiratory journal 1997 (PubMed)
    Show all 2 references for ABIN1098729

More Proteins for Tachykinin, Precursor 1 (TAC1) Interaction Partners

Mouse (Murine) Tachykinin, Precursor 1 (TAC1) interaction partners

  1. Data show that estrogen receptor alpha (ERalpha (show ESR1 Proteins)) in tachykinin 2 protein (Tac2) neurons typically restrains pubertal onset and hypothalamic reproductive drive.

  2. RNA-binding protein Msi1 (show MSI1 Proteins) competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation

  3. Results reveal that EM-2, Leu-Enk (show PENK Proteins) and Dyn (show PDYN Proteins) A were down-regulated in Tac1-/- spinal cord tissues.

  4. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS (show NOS1 Proteins) and the NK-1R (show TACR1 Proteins)

  5. Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R (show TACR1 Proteins)-NOX2 (show CYBB Proteins) axis-mediated pathway.

  6. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha (show ESR1 Proteins), NKX2-1 (show NKX2-1 Proteins), and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.

  7. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin (show GHRL Proteins) administration and to changes in the status of the gonadal function.

  8. Tac2-/- females had delays in sexual maturation, with time to vaginal opening and first estrus occurring later than controls. However, cycling recovered in adulthood and Tac2-/- females were fertile, although they produced fewer pups per litter.

  9. Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification.

  10. In vivo ozone(O3)-induced elevations in both nerve growth factor (NGF) and substance P (SP) are mediated by the inflammatory cytokine interleukin-1beta. Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue.

Human Tachykinin, Precursor 1 (TAC1) interaction partners

  1. Circulating Neurokinin A >/= 50 ng/L is a strong indicator of poor prognosis when Neurokinin A remains above this concentration

  2. Substance P enhances tissue factor (show F3 Proteins) release from granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins)-dependent macrophages via the p22phox (show CYBA Proteins)/beta-arrestin 2 (show ARRB2 Proteins)/Rho A (show RHOA Proteins) signaling pathway.

  3. Decrease of mGluR5 (show GRM5 Proteins) receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease

  4. Report absence of full-length neurokinin-1 receptor protein expression by cutaneous T cells in mycosis fungoides and discuss substance P signaling.

  5. Substance P was significantly increased in hypertrophic scars compared with matched unburned skin. In the reticular dermis and papillary dermis, SP represented significant correlation with pain.

  6. High TAC1 expression is associated with breast cancer.

  7. An increased presence of Substance P in the trochanteric bursa may be related to the pain associated with greater trochanteric pain syndrome.

  8. Substance P is upregulated in the serum of patients with chronic spontaneous urticaria

  9. SP may influence the KP and NKB secretory output via additional autocrine/paracrine mechanisms or regulate GnRH neurosecretion directly.

  10. we define a three-gene panel, CDO1 (show CDO1 Proteins), HOXA9 (show HOXA9 Proteins), and TAC1, which we subsequently validate in two independent cohorts of primary NSCLC samples

Cow (Bovine) Tachykinin, Precursor 1 (TAC1) interaction partners

  1. Substance P alters the cytokine and chemokine (show CCL1 Proteins) expression pattern in monocytes and blood-monocyte-derived macrophages.

Rabbit Tachykinin, Precursor 1 (TAC1) interaction partners

  1. There is an increase in the sensitivity of rapidly adapting receptor (RAR (show RAB40B Proteins)) activity to substance P (SP) during high altitude exposure.

  2. Increased substance P-production precedes tendinosis, since tendinosis-like changes occur only after a minimum of 3 weeks of exercise

Tachykinin, Precursor 1 (TAC1) Protein Profile

Protein Summary

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tachykinin, Precursor 1 Proteins (TAC1)

  • tachykinin, precursor 1 (TAC1)
  • protachykinin-1 (tkn1)
  • tachykinin 1 (Tac1)
  • tachykinin 2 (Tac2)
  • tachykinin, precursor 1 (Tac1)
  • 4930528L02Rik protein
  • beta-PPT-A protein
  • Hs.2563 protein
  • NK-1 protein
  • NK1 protein
  • NK2 protein
  • NKNA protein
  • NPK protein
  • PPT protein
  • PPT-A protein
  • Ppt5fl protein
  • PPTA protein
  • PPTA3 protein
  • RATPPTA3 protein
  • SP protein
  • TAC protein
  • TAC1 protein
  • TAC2 protein
  • Tac3 protein

Protein level used designations for Tachykinin, Precursor 1 Proteins (TAC1)

tachykinin, precursor 1 , tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) , protachykinin-1 , tachykinin 1 , preprotachykinin , PPT , neurokinin 1 , neurokinin A , preprotachykinin A , substance P , delta preprotachykinin I , PPT-B , neurokinin 2 , neurokinin B-like protein Zneurok1 , neurokinin alpha , neuromedin L , neuropeptide K , preprotachykinin-B , substance K , tachykinin-3 , neuropeptide gamma , tachykinin 2 , protachykinin-1 preproprotein , Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma) , preprotachykinin I , substance P, neuropeptide gamma, neurokinin A

475239 Canis lupus familiaris
697350 Macaca mulatta
100034669 Ovis aries
100528498 Ictalurus punctatus
21333 Mus musculus
100379583 Cavia porcellus
21334 Mus musculus
6863 Homo sapiens
281512 Bos taurus
24806 Rattus norvegicus
100009275 Oryctolagus cuniculus
420573 Gallus gallus
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