Tenascin XB Proteins (TNXB)

TNXB encodes a member of the tenascin family of extracellular matrix glycoproteins. Additionally we are shipping TNXB Antibodies (55) and TNXB Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TNXB TNXB 415089  
TNXB 7148 P22105
TNXB 81877  
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Top TNXB Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days

TNXB Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Top referenced TNXB Proteins

  1. Human TNXB Protein expressed in Wheat germ - ABIN1323312 : Hu, Zhang, Zhang, Li, Zhu, Shao, Zeng, Xu: Comparative serum proteome analysis of human lymph node negative/positive invasive ductal carcinoma of the breast and benign breast disease controls via label-free semiquantitative shotgun technology. in Omics : a journal of integrative biology 2009 (PubMed)

More Proteins for Tenascin XB (TNXB) Interaction Partners

Human Tenascin XB (TNXB) interaction partners

  1. patients with the TNX-deficient type EDS typically have generalized joint hypermobility, skin hyperextensibility and easy bruising. In contrast to the classical type, the inheritance pattern is autosomal recessive and atrophic scarring is absent. Molecular analysis of TNXB in a diagnostic setting is challenging.

  2. the identification of a rare missense variant in TNXB in combination with a positive family history of VUR and joint hypermobility may represent a non-invasive method to diagnose PVUR and warrants further evaluation in other cohorts

  3. We then quantified the tenascin-X level in serum of patients and identified tenascin-X as potent marker for ovarian cancer, showing that secretomic analysis is suitable for the identification of protein biomarkers when combined with protein immunoassay.

  4. these results suggest that mutations in TNXB can cause hereditary primary vesicoureteral reflux .

  5. Noticeable decreased expression of tenascin-X in calcific aortic valves.

  6. Tenascin-X haploinsufficiency was associated with Ehlers-Danlos syndrome in patients with congenital adrenal hyperplasia

  7. Genome-wide association study of age-related macular degeneration identifies TNXB, FKBPL (show FKBPL Proteins) and NOTCH4 (show NOTCH4 Proteins) as candidate susceptibility genes.

  8. Combined analysis of tenascin-C (show TNC Proteins) expression and the nodule size improved the prediction of malignancy in this patient cohort.

  9. rs204887 itself or a nearby variant is unlikely to play a major role in the development of schizophrenia although a cumulative contribution of rare variants in the TNXB gene cannot be ruled out.

  10. Three point mutations in TNX gene were found to be associated with hypermobility type Ehlers-Danlos syndrome (EDS) . The phenotypic effects of V1195M mutation on 7th fibronectin (show FN1 Proteins) Type III domain (TNXfn7) with regards to EDS were investigated.

Mouse (Murine) Tenascin XB (TNXB) interaction partners

  1. Tenascin-x is an initiator of myocardial fibrosis and ACM development via upregulation of TGFbeta (show TGFB1 Proteins)(1) and downregulation of PPARgamma (show PPARG Proteins).

  2. Altered properties of the force transmission pathways of muscle due to TNX deficiency directly affect muscle function in TNX KO mice. Such effects are likely to contribute to muscle weakness experienced by patients with Ehlers-Danlos syndrome.

  3. Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition

  4. TNX has either a redundant or a very subtle function in the macromolecular organization in the peripheral nerve

  5. Tnx plays a role in the regulation of cell-cell and cell-matrix interactions: Tnx-null fibroblasts exhibit weaker adhesive properties to fibronectin (show FN1 Proteins) and B16 melanoma cells than do wild-type fibroblasts.

  6. Induction of MMP-2 (show MMP2 Proteins) by Tnx deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase (show YES1 Proteins) phosphorylation pathway.

  7. TNX is unlikely to be involved in matrix deposition in the early phase of wound healing, but it is required in the later phase when remodeling and maturation of the matrix establishes and improves its biomechanical properties.

  8. TNX knockout mice have mild pregnancy-related abnormalities.

  9. localizations of Tn-X in the leptomeningeal trabecula (TB) of adult mice and in the connective tissue of the choroid plexus (CP) in the brains of mice

Cow (Bovine) Tenascin XB (TNXB) interaction partners

  1. Tenascin-X promotes activation of latent TGF-beta1 (show TGFB1 Proteins) and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

  2. mechanical analysis of collagen gels showed an increased compressive resistance of the gels containing tenascin-X, indicating that this protein might be directly involved in determining the mechanical properties of collagen-rich tissues in vivo.

  3. tenascin-X, via trimerization and multiple interactions with components of collagenous fibrils, plays a crucial role in the organisation of extracellular matrices.

  4. Tenascin-X is an elastic protein and the fibronectin (show FN1 Proteins) type III (FnIII) domains can unfold under a stretching force and refold to regain their mechanical stability upon the removal of the stretching force.

TNXB Protein Profile

Protein Summary

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tenascin XB Proteins (TNXB)

  • tenascin XB (Tnxb)
  • tenascin XB (TNXB)
  • tenascin-X (TN-X)
  • EDS3 protein
  • HXBL protein
  • TENX protein
  • Tn-mhc protein
  • TN-X protein
  • TN-Y protein
  • TNX protein
  • TNXB protein
  • TNXB1 protein
  • TNXB2 protein
  • TNXBS protein
  • XB protein
  • XBS protein

Protein level used designations for Tenascin XB Proteins (TNXB)

tenascin X pseudogene , tenascin XB , tenascin Y , tenascin X B , tenascin-X-like , growth-inhibiting protein 45 , hexabrachion-like protein , tenascin XB1 , tenascin XB2 , tenascin-X , tenascin X

415089 Rattus norvegicus
396106 Gallus gallus
462578 Pan troglodytes
750749 Pan troglodytes
100434533 Pongo abelii
100597679 Nomascus leucogenys
7148 Homo sapiens
81877 Mus musculus
100682877 Canis lupus familiaris
282654 Bos taurus
445520 Sus scrofa
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