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Tocopherol (Alpha) Transfer Protein Proteins (TTPA)

TTPA encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. Additionally we are shipping TTPA Antibodies (27) and TTPA Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TTPA 7274 P49638
TTPA 25571 P41034
TTPA 50500 Q8BWP5
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Top TTPA Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

TTPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Tocopherol (Alpha) Transfer Protein (TTPA) Interaction Partners

Human Tocopherol (Alpha) Transfer Protein (TTPA) interaction partners

  1. Single-nucleotide polymorphisms that are commonly found in healthy humans dramatically affect promoter activity of the TTPA gene.

  2. The crystal structure of the alpha-TTP-phosphatidylinositol phosphates (PIPs (show GPRASP1 Proteins)) complex revealed that the familial vitamin E deficiency-related arginine residues interacted with phosphate groups of the PIPs (show GPRASP1 Proteins) and that the PIPs (show GPRASP1 Proteins) binding caused the lid of the alpha-tocopherol-binding pocket to open.

  3. Data show that reduction ("knockdown") of tocopherol transfer protein (TTP (show ADAMTS13 Proteins)) expression resulted in resistance to the vitamin E.

  4. Substitution of residues in helices A8 (F165A and F169A) and A10 (I202A, V206A and M209A) decreased the rate of intermembrane ligand transfer as well as protein adsorption to phospholipid bilayers.

  5. First case of a mutated form of the TTPA gene in a patient also carrying a spinocerebellar ataxia (show USP14 Proteins) type 8 expansion.

  6. the positively charged surface of TTPA may serve to orient an interacting protein, which might function to regulate the release of alpha-T through an induced change in conformation of ATTP

  7. Findings suggest the possibility that ataxia (show USP14 Proteins) with vitamin E deficiency syndrome (AVED) may not arise from an inability of TTP (show ADAMTS13 Proteins) to bind or to transfer alpha tocopherol, but rather from defects in other activities of the protein.

  8. Nuclear localization of TTPA in in trophoblast, fetal capillaries' endothelium and amnion epithelium of human term placentamay represent a novel function of TTPA

  9. In Ataxia (show USP14 Proteins) with vitamin E deficiency two TTPA mutations were identified: a truncating mutation in a homozygous patient, and a Gly246Arg missense mutation in a compound heterozygous patient associated with a mild and slowly progressive form of the disease.

  10. The physiological role of TTP (show ADAMTS13 Proteins) is anchored in its ability to direct vitamin E trafficking from the endocytic compartment to transport vesicles that deliver the vitamin to the site of secretion at the plasma membrane.

Mouse (Murine) Tocopherol (Alpha) Transfer Protein (TTPA) interaction partners

  1. Results suggest that lipid peroxidation due to depletion of alpha-tocopherol impairs Abeta (show APP Proteins) clearances from the brain and from the blood, possibly causing increased Abeta (show APP Proteins) accumulation in Ttpa(-/-)APPsw brain and plasma.

  2. Endogenous TTPA, through the enhancement of MMP 9 (show MMP9 Proteins) expression and proteolytic activation, plays an essential role in the pathogenesis of heparin-produced cerebral hemorrhage.

  3. TTP (show ZFP36 Proteins) transports alpha-TCP and oral administration of TTP (show ZFP36 Proteins) compensates for TTP (show ZFP36 Proteins) in TTP (show ZFP36 Proteins)-deficient mice

  4. These data suggest that in vivo network of alpha-tocopherol (AT), AT-metabolites and ATTP (show UEVLD Proteins) affects the transcription of genes driven by AhR (show AHR Proteins), Nrf2 (show NFE2L2 Proteins) and NF-kappaB (show NFKB1 Proteins), transcription factor networks.

  5. p75(NTR (show NGFR Proteins))is up-regulated after tissue injury, blocks fibrinolysis by down-regulating the serine protease (show F2 Proteins), tissue plasminogen activator (show PLAT Proteins), and up-regulating PAI-1 (show SERPINE1 Proteins).

  6. changes in hepatic TTP (show ZFP36 Proteins) concentrations were minimal in response to dietary vitamin E levels or environmental tobacco smoke-related oxidative stress

  7. Increase expression of tPA implicate fibrinolysis in ALD progression.

TTPA Protein Profile

Protein Summary

This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.

Gene names and symbols associated with TTPA

  • tocopherol (alpha) transfer protein (TTPA)
  • tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency) (ttpa)
  • tocopherol (alpha) transfer protein (Ttpa)
  • alpha-TTP protein
  • alphaTTP protein
  • ATTP protein
  • AVED protein
  • TTP protein
  • TTP1 protein

Protein level used designations for TTPA

alpha-tocopherol transfer protein , tocopherol (alpha) transfer protein , alpha-TTP , tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency) , Alpha-tocopherol transfer protein , Tocopherol transfer protein alpha , alpha TTP

286813 Bos taurus
403627 Canis lupus familiaris
472778 Pan troglodytes
771074 Gallus gallus
100196332 Salmo salar
100526668 Ovis aries
7274 Homo sapiens
25571 Rattus norvegicus
50500 Mus musculus
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