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TCF21 encodes a transcription factor of the basic helix-loop-helix family. Additionally we are shipping TCF21 Proteins (8) and TCF21 Kits (5) and many more products for this protein.
Showing 10 out of 48 products:
Zebrafish (Danio rerio) Polyclonal TCF21 Primary Antibody for WB - ABIN1881873
Wang, Chen, Yao, Zheng, Yang: Phylogenetic analysis of zebrafish basic helix-loop-helix transcription factors. in Journal of molecular evolution 2009
Show all 3 references for ABIN1881873
Human Polyclonal TCF21 Primary Antibody for IHC, IHC (p) - ABIN4358092
Sazonova, Zhao, Nürnberg, Miller, Pjanic, Castano, Kim, Salfati, Kundaje, Bejerano, Assimes, Yang, Quertermous: Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. in PLoS genetics 2015
Show all 2 references for ABIN4358092
Chicken Polyclonal TCF21 Primary Antibody for IHC, WB - ABIN2777930
Funato, Ohyama, Kuroda, Nakamura: Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription. in The Journal of biological chemistry 2003
Chicken Polyclonal TCF21 Primary Antibody for WB - ABIN2780489
Smith, Lin, Brena, Lang, Schuller, Otterson, Morrison, Smiraglia, Plass: Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. in Proceedings of the National Academy of Sciences of the United States of America 2006
Human Polyclonal TCF21 Primary Antibody for EIA, FACS - ABIN955127
Colland, Jacq, Trouplin, Mougin, Groizeleau, Hamburger, Meil, Wojcik, Legrain, Gauthier: Functional proteomics mapping of a human signaling pathway. in Genome research 2004
Human Polyclonal TCF21 Primary Antibody for FACS, WB - ABIN655524
Dai, Duan, Duan, Zhou, He, Tu, Shen: Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer. in Biochemical and biophysical research communications 2015
These findings show that POD-1/TCF21 regulates SF-1 (show NR5A1 Antibodies) and LRH-1 (show NR5A2 Antibodies) by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis.
TCF21 may function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in CRC (show CALR Antibodies) development.
The presence of significant hypermethylation of TCF21 supports the hypothesis that hypermethylation of TCF21 and/or decreased TARID expression lies within the pathogenic pathway of most CCSKs.
our data provided the first evidence that TCF21 mRNA is significantly downregulated in breast cancer cell lines and tissues and regulates breast cancer cell proliferation and EMT (show ITK Antibodies).
Separate enrichment analyses found over-representation of TCF21 target genes among CAD (show CAD Antibodies) associated genes, and linkage disequilibrium between TCF21 peak variation and that found in GWAS loci consistent with the hypothesis that TCF21 may affect disease risk
Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function
TCF21 could inhibit the proliferation and migration of SMMC-7721 hepatocellular carcinoma cells and promote its apoptosis
Low TCF21 expression is associated with gastric cancer.
TCF21 inhibits the proliferation and migration and facilitates early apoptosis of A549 cells.
these data suggest that miR (show MLXIP Antibodies)-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2
During normal heart development, spatio-temporal differences in contribution of WT-1 (show WT1 Antibodies) and Tcf21-LacZ (show GLB1 Antibodies) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.
TCF21 may have a role regulating the differentiation state of SMC (show DYM Antibodies) precursor cells that migrate into vascular lesions and contribute to the fibrous cap and more broadly, in view of the association of this gene with human Coronary Artery Disease
Our results demonstrate a critical role for Tcf21 in the differentiation and maintenance of podocytes.
Data indicate that loss of Pod1/Tcf21 leads to epicardial blistering, increased smooth muscle cell differentiation on the surface of the heart, and a paucity of interstitial fibroblasts, with neonatal lethality.
The majority of Tcf21-expressing epicardial cells are committed to the cardiac fibroblast lineage prior to initiation of epicardial epithelial-to-mesenchymal transition.
Data show that correct levels of expression of Myf5 (show MYF5 Antibodies) and MyoD (show MYOD1 Antibodies) during mouse craniofacial development result from activation by musculin (show MSC Antibodies) and TCF21 through direct binding to specific enhancers.
epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation
findings identify MyoR (show MSC Antibodies) and capsulin as unique transcription factors for the development of specific head muscles
cell autonomous and non-cell autonomous roles for Pod1 in the differentiation of specific renal cell lineages that include peritubular interstitial cells and pericytes.
Pod-1, which controls androgen receptor (show AR Antibodies) transcription and function, may play an important role in the development and function of the testis.
Tcf21 functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium
Distribution of a basic helix-loop-helix transcription factor (show HEY1 Antibodies) expressed very early in the development of the pronephric glomus is described.
Capsulin has an essential role in zebrafish craniofacial myogenesis.
Upstream sequences of the transcription factor gene tcf21 activate robust, epicardium-specific expression throughout development and regeneration.
Endogenous Capsulin was distributed mainly in the epicardial cells of zebrafish.
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.
transcription factor 21
, pod 1
, podocyte-expressed 1
, Transcription factor 21
, 70 kDa WD repeat tumor rejection antigen homolog
, class A basic helix-loop-helix protein 23
, Pod 1
, Podocyte-expressed 1