Transcription Factor EB Proteins (TFEB)

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Antibodies (151) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TFEB 7942 P19484
TFEB 21425 Q9R210
Rat TFEB TFEB 316214  
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Top Transcription Factor EB Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details

TFEB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Transcription Factor EB Proteins

  1. Human TFEB Protein expressed in Escherichia coli (E. coli) - ABIN2733467 : Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. in Autophagy 2016 (PubMed)

More Proteins for Transcription Factor EB (TFEB) Interaction Partners

Human Transcription Factor EB (TFEB) interaction partners

  1. Consistent with reduced transcription factor EB (TFEB) activity, accumulation of phosphorylated TFEB in STUB1 (show STUB1 Proteins)-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.

  2. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of murine models of disease, such as Parkinson's and Alzheimer's, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity.

  3. Amplification of chromosome 6p including the TFEB gene is a novel occurrence in renal cell carcinoma (show MOK Proteins), which seems to be associated with an often aggressive and infiltrative tubulopapillary growth pattern.

  4. TFEB-amplified renal cell carcinomas represent a distinct molecular subtype of high-grade adult renal cell carcinomas associated with aggressive clinical behavior, variable morphology, and aberrant melanocytic marker expression

  5. Case Report: suggest that extensive sclerosis and ossification may be a less common recurring histology of TFEB-rearrangement renal cell carcinoma (show MOK Proteins).

  6. Overexpression of deacetylated transcription factor EB at K116R mutant in microglia accelerated intracellular fibrillar Amyloid beta-peptide degradation by stimulating lysosomal biogenesis and greatly reduced the deposited amyloid plaques in the brain.

  7. the central autophagy regulator TFEB is expressed and active in PDAC, but autophagy is sustained after TFEB knockdown, suggesting alternative bypass signaling. TFEB is dispensable for gemcitabine-induced cell death, but inversely correlated with KRAS expression.

  8. Neuronal C-ETS2 (show ETS2 Proteins) senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes.

  9. Activation of TFEB ameliorates disease phenotypes in a mouse model of Batten disease.

  10. Lack of cystinosin (show CTNS Proteins) reduced TFEB expression and induced TFEB nuclear translocation.

Mouse (Murine) Transcription Factor EB (TFEB) interaction partners

  1. Tfe3 (show TFE3 Proteins) and Tfeb are required for the induced expression of Ppargamma2 (show PPARG Proteins) and subsequently for adipogenic genes.

  2. our data indicate that PPAR-alpha (show PPARA Proteins) mediates antimicrobial responses to mycobacterial infection by inducing TFEB and lipid catabolism.

  3. Consistent with reduced transcription factor EB (TFEB) activity, accumulation of phosphorylated TFEB in STUB1 (show STUB1 Proteins)-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.

  4. These findings identify TFEB as a critical mediator of the beneficial effects of exercise on metabolism.

  5. Consistent with reduced mTOR (show FRAP1 Proteins) activity and increased TFEB levels, loss of C9orf72 (show C9ORF72 Proteins) enhances autophagic flux, suggesting that C9orf72 (show C9ORF72 Proteins) is a negative regulator of autophagy

  6. these results uncover a potent role for TFEB-mediated autophagy in the pathogenesis of Cd-induced neurotoxicity, suggesting that control of the autophagic pathway by melatonin might provide an important clue for exploring potential targets for novel therapeutics of Cd-induced neurotoxicity.

  7. TFEB mediated autophagy is crucial for protection against lipopolysaccharide induced myocardial injury particularly in aging senescent heart.

  8. Acute and chronic ethanol administration affects TFEB localization in the liver and regulates hepatic autophagy.

  9. TFEB and TFE3 (show TFE3 Proteins) are novel components of the integrated stress response

  10. TFEB-regulated signaling pathway for osteoblast differentiation is involved in ATF4 (show ATF4 Proteins)/CHOP (show DDIT3 Proteins)-dependent signaling pathway.

Zebrafish Transcription Factor EB (TFEB) interaction partners

  1. The zebrafish genome contain two mitf (mitfa (show MITF Proteins) and mitfb (show MITF Proteins)), two tfe3 (show TFE3 Proteins) (tfe3a and tfe3b), and single tfeb and tfec (show TFEC Proteins) genes.

Transcription Factor EB (TFEB) Protein Profile

Protein Summary

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Gene names and symbols associated with Transcription Factor EB Proteins (TFEB)

  • transcription factor EB (TFEB)
  • transcription factor EB (tfeb)
  • transcription factor EB (Tfeb)
  • ALPHATFEB protein
  • bHLHe35 protein
  • MGC145796 protein
  • Tcfeb protein
  • TFEB protein

Protein level used designations for Transcription Factor EB Proteins (TFEB)

transcription factor EB , transcription factor EB-like , T-cell transcription factor EB , class E basic helix-loop-helix protein 35

GENE ID SPECIES
100066433 Equus caballus
694214 Macaca mulatta
748433 Pan troglodytes
780105 Xenopus (Silurana) tropicalis
100137208 Papio anubis
100449854 Pongo abelii
100583940 Nomascus leucogenys
7942 Homo sapiens
21425 Mus musculus
562289 Danio rerio
419922 Gallus gallus
609046 Canis lupus familiaris
100157940 Sus scrofa
510032 Bos taurus
100328714 Oryctolagus cuniculus
316214 Rattus norvegicus
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