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Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Antibodies (155) and many more products for this protein.
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Human TFEB Protein expressed in Escherichia coli (E. coli) - ABIN2733467
Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. in Autophagy 2016
Overexpression of deacetylated transcription factor EB at K116R mutant in microglia accelerated intracellular fibrillar Amyloid beta-peptide degradation by stimulating lysosomal biogenesis and greatly reduced the deposited amyloid plaques in the brain.
the central autophagy regulator TFEB is expressed and active in PDAC, but autophagy is sustained after TFEB knockdown, suggesting alternative bypass signaling. TFEB is dispensable for gemcitabine-induced cell death, but inversely correlated with KRAS expression.
Neuronal C-ETS2 (show ETS2 Proteins) senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes.
Activation of TFEB ameliorates disease phenotypes in a mouse model of Batten disease.
Lack of cystinosin (show CTNS Proteins) reduced TFEB expression and induced TFEB nuclear translocation.
The autophagic response to polystyrene nanoparticles is mediated by TFEB and depends on surface charge.
Review of the role of TFEB in lysosome biogenesis, transcriptional and post-transcriptional regulation of TFEB, and TFEB involvement in neurodegenerative disease as a dysregulated factor or as an agent used to promote cellular clearance.
TFEB and TFE3 (show TFE3 Proteins) are novel components of the integrated stress response
Silencing of TFEB with siRNAs in lung cancer cell lines resulted in reduced migration ability.
during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1 (show PINK1 Proteins)- and Parkin (show PARK2 Proteins)-dependent manner.
these results uncover a potent role for TFEB-mediated autophagy in the pathogenesis of Cd-induced neurotoxicity, suggesting that control of the autophagic pathway by melatonin might provide an important clue for exploring potential targets for novel therapeutics of Cd-induced neurotoxicity.
TFEB mediated autophagy is crucial for protection against lipopolysaccharide induced myocardial injury particularly in aging senescent heart.
Acute and chronic ethanol administration affects TFEB localization in the liver and regulates hepatic autophagy.
TFEB-regulated signaling pathway for osteoblast differentiation is involved in ATF4 (show ATF4 Proteins)/CHOP (show DDIT3 Proteins)-dependent signaling pathway.
TFEB participates in the Amyloid-beta-induced pathogenesis of Alzheimer's disease by regulating the autophagy-lysosome pathway in transgenic mice model of Alzheimer's disease.
Data indicate that transcription factor TFEB is a key participant in the differential regulation of the presentation of exogenous antigens by dendritic cells (DCs).
TFEB specifically targets hyperphosphorylated and misfolded Tau species present in both soluble and aggregated fractions while leaving normal Tau intact.
We examined the transcriptional regulation of autophagy and observed a functionally significant physical interaction between TFEB and AR in spinal and bulbar muscular atrophy (show AR Proteins).
TFEB was rapidly activated in murine macrophages upon S. aureus infection and was required for proper transcriptional induction of several proinflammatory cytokines and chemokines.
The zebrafish genome contain two mitf (mitfa (show MITF Proteins) and mitfb (show MITF Proteins)), two tfe3 (show TFE3 Proteins) (tfe3a and tfe3b), and single tfeb and tfec (show TFEC Proteins) genes.
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
transcription factor EB
, transcription factor EB-like
, T-cell transcription factor EB
, class E basic helix-loop-helix protein 35