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The protein encoded by TAGLN2 is a homolog of the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. Additionally we are shipping Transgelin 2 Proteins (15) and Transgelin 2 Kits (11) and many more products for this protein.
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Human Polyclonal TAGLN2 Primary Antibody for IHC (p), WB - ABIN657984
Rho, Roehrl, Wang: Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. in Journal of proteome research 2009
Show all 3 references for ABIN657984
Human Polyclonal TAGLN2 Primary Antibody for ICC, IF - ABIN4361997
Yoshino, Chiyomaru, Enokida, Kawakami, Tatarano, Nishiyama, Nohata, Seki, Nakagawa: The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. in British journal of cancer 2011
Show all 3 references for ABIN4361997
All these results indicated a crucial role for Tagln2 in TECs for tumor development and metastasis.
A novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the immunological synapse.
The results indicate that miR (show MLXIP Antibodies)-133b may play important roles in the growth and maturation of oocytes by regulating its potential target, TAGLN2, at both transcription and translation levels.
we demonstrate that methylation of SM22alpha (show TAGLN Antibodies) promoter is an important event in vascular smooth muscle cell calcification and that high phosphate induces this epigenetic modification.
data demonstrate that SM22beta is a novel actin-associated protein with a unique cell lineage-restricted pattern of expression
Transgelin-2 plays functional roles in the progression of cervical squamous cell carcinoma. Suppression of Transgelin-2 may be a new strategy for the treatment of cervical squamous cell carcinoma.
It is a target gene of miR-1.
Salvianolic acid A can reverse the paclitaxel resistance and inhibit the migration and invasion abilities of human breast cancer cells by down-regulating the expression of transgelin 2.
Proteomics result showed TAGLN2 as the most significant overexpression in individual bladder cancer tissues and urine specimens, and thus represents a potential biomarker for noninvasive screening for bladder cancer.
TAGLN2 modulates hypoxia-induced apoptosis via caspase-8 (show CASP8 Antibodies) apoptotic pathway. Taken together, our data demonstrated the roles of miR (show MLXIP Antibodies)-133a in hypoxia-induced apoptotic and implicate its potential in cardiac dysfunctions therapy.
Transgelin-2, a sequence homolog of transgelin (show TAGLN Antibodies), whose role in the tumor development might be contradictory to the role of transgelin (show TAGLN Antibodies).
PTTG1 (show PTTG1 Antibodies) and TAGLN2 are highly expressed in human pancreatic cancer, and the positive expression of PTTG1 (show PTTG1 Antibodies) is associated with the gender of cancer patients, suggesting that it may represent a potential therapeutic target for the treatment of pancreatic cancer
our data propose a novel, oncogene (show RAB1A Antibodies)-tumor suppressor interplay, where oncogenic PFTK1 (show CDK14 Antibodies) confers HCC (show FAM126A Antibodies) cell motility through inactivating the actin-binding motile suppressing function of TAGLN2 via phosphorylation.
Data indicate that TAGLN2 may have an oncogenic function and may be regulated by miR-1, a tumor suppressive miRNA in HNSCC.
in pulmonary adenocarcinoma, overexpression of TAGLN (show TAGLN Antibodies) was strictly localized to the tumor-induced reactive myofibroblastic stromal tissue compartment, whereas overexpression of TAGLN2 was exclusively localized to the neoplastic glandular compartment
The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene.
, SM22-alpha homolog
, epididymis tissue protein Li 7e