UBX Domain Protein 6 Proteins (UBXN6)

Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. Additionally we are shipping UBXN6 Antibodies (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat UBXN6 UBXN6 363332  
UBXN6 80700 Q9BZV1
Mouse UBXN6 UBXN6 66530 Q99PL6
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Top UBXN6 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Yeast His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

UBXN6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for UBX Domain Protein 6 (UBXN6) Interaction Partners

Human UBX Domain Protein 6 (UBXN6) interaction partners

  1. Upon damage, p97 (show EIF4G2 Proteins) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA (show PLAA Proteins), and the deubiquitinating enzyme YOD1 (show YOD1 Proteins), which we term ELDR components for Endo-Lysosomal Damage Response.

  2. UBXD1-N intercalates into the p97 (show EIF4G2 Proteins)-ND1 (show MT-ND1 Proteins) interface, thereby modulating interdomain communication of p97 (show EIF4G2 Proteins) domains and its activity with relevance for disease pathogenesis

  3. Data indicate that endosomal trafficking of CAV1 (show CAV1 Proteins) depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP (show vcp Proteins)-UBXD1.

  4. UBXD1 modulates the trafficking of ERGIC-53 (show LMAN1 Proteins)-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53 (show LMAN1 Proteins).

  5. Data show that expression of VCP (show vcp Proteins) mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 (show CAV1 Proteins) transport at the limiting membrane of enlarged endosomes in cultured cells.

  6. UBXD1 is a novel co-factor of the human p97 ATPase (show vcp Proteins).

  7. An additional p97 (show EIF4G2 Proteins) binding site in UBXD1 that competed with the p47 (show ING1 Proteins) cofactor for binding to the N domain of p97 (show EIF4G2 Proteins) was identified.

  8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP.

UBXN6 Protein Profile

Protein Summary

Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity).

Gene names and symbols associated with UBX Domain Protein 6 Proteins (UBXN6)

  • UBX domain protein 6 (Ubxn6)
  • UBX domain protein 6 (UBXN6)
  • 1200008L11Rik protein
  • 2210415J11Rik protein
  • AU040909 protein
  • UBXD1 protein
  • Ubxdc2 protein

Protein level used designations for UBX Domain Protein 6 Proteins (UBXN6)

UBX domain containing 1 , UBX domain-containing protein 6 , UBX domain protein 6 , UBX domain-containing 1 , UBX domain-containing 2 , UBX domain-containing protein 1

363332 Rattus norvegicus
715070 Macaca mulatta
100018491 Monodelphis domestica
100589901 Nomascus leucogenys
80700 Homo sapiens
66530 Mus musculus
507936 Bos taurus
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