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UDB17 encodes a member of the uridine diphosphoglucuronosyltransferase protein family.
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Chronic lymphocytic leukemia patients with high UGT2B17 and LPL (show LCP1 Antibodies) expression have significantly reduced survival.
UGT2B17 contributes to the in-vitro glucuronidation of arctigenin in liver/intestinal microsomes.
GC-C-IRMS analysis sensitive to testosterone doping independent of UGT2B17 genotype.
UGT2B17 mismatch has a negative clinical impact in allogeneic HSCT from HLA-identical sibling donors only when a male donor is used.
This descriptive study examines correlations between concentrations of tamoxifen's glucuronide metabolites and genotypes UGT1A4 (show UGT1A4 Antibodies), UGT2B7 (show UGT2B7 Antibodies), UGT2B15 (show UGT2B15 Antibodies) and UGT2B17 in 132 patients with estrogen receptor (show ESR1 Antibodies)-positive breast cancer under treatment with tamoxifen.
miR (show MLXIP Antibodies)-376c is inversely linked to UGT2B15 (show UGT2B15 Antibodies) and UGT2B17 expression in high-grade prostate cancer and metastasis.UGT2B15 and UGT2B17 genes are direct targets of miR (show MLXIP Antibodies)-376c and thus may influence steroid metabolism during prostate cancer progression.
UGT2B17 deletion polymorphisms are associated with the risk of developing pancreatic cancer in Chinese Han population, especially in the female population.
UGT2B17-deletion interacting with p16 (show CDKN2A Antibodies) (+) may modify effects of smoking on TP53 (show TP53 Antibodies)-mutations and may further interact with the disruptive TP53 (show TP53 Antibodies)-mutations to raise relapse rates among Japanese patients with head and neck squamous cell carcinomas.
These data suggest that UGT2B17 deletion leads to reduced UGT2B17 activity, and lower BMI in male individuals. This is consistent with the hypothesis that reduced UGT2B17-mediated testosterone excretion results in higher testosterone levels
Expression of UGT2B15 (show UGT2B15 Antibodies) and UGT2B17 is negatively regulated by the binding of miR (show MLXIP Antibodies)-376c.
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.
, C19-steroid-specific UDPGT
, UDP glycosyltransferase 2 family, member B17
, UDP-glucuronosyltransferase 2B17
, UDP-glucuronyltransferase, family 2, beta-17