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URI1 encodes member of the prefoldin family of molecular chaperones. Additionally we are shipping URI1, Prefoldin-Like Chaperone Antibodies (34) and many more products for this protein.
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RMP (show ABCA4 Proteins) status in tumors may be a useful marker in estimating prognosis in patients with hepatocellular carcinoma and in assisting in the selection of patients who are likely to benefit from adjuvant TACE (show ADAM17 Proteins) to prevent relapse.
High URI1 expression is associated with epithelial ovarian cancer.
Results show that URI expression is essential for hepatocarcinogenesis and associated with poor survival.
URI may have an important role in the development of multiple myeloma and chemotherapeutic resistance through activation of the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) pathway.
Higher level of URI/RMP expression in high-grade endometrioid adenocarcinomas compared to tissues of adjacent endometrium or gland suggests a diagnostic and possibly, a prognostic value of URI/RMP in endometrioid adenocarcinoma.
Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes.
Data show that URI is an "addicting" oncogene selectively required for the survival of ovarian cancer cells with increased URI copy number.
Data show that URI and PP1gamma are components of an S6K1 (show RPS6KB1 Proteins)-regulated mitochondrial pathway dedicated to oppose sustained S6K1 (show RPS6KB1 Proteins) survival signaling and to ensure that the threshold for apoptosis is set based on nutrient and growth factor availability.
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22.
RNA polymerase II subunit 5-mediating protein
, RPB5-mediating protein
, protein phosphatase 1 regulatory subunit 19
, protein phosphatase 1, regulatory subunit 19
, unconventional prefoldin RPB5 interactor 1