Ubiquitin Specific Peptidase 17-Like 2 Proteins (USP17L2)

Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Additionally we are shipping USP17L2 Antibodies (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse USP17L2 USP17L2 109998  
USP17L2 377630 Q6R6M4
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Top USP17L2 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

USP17L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) Interaction Partners

Mouse (Murine) Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

  1. Using a reporter assay, we show that NCoA1 potentiates Esrrb-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 splice variant NCoA1 and Esrrb

  2. We show that Dub3 expression is strongly downregulated during neural conversion and precedes Cdc25A (show CDC25A Proteins) destabilization, while forced Dub3 expression in ESCs (show NR2E3 Proteins) becomes lethal upon differentiation

Human Ubiquitin Specific Peptidase 17-Like 2 (USP17L2) interaction partners

  1. these data identify DUB3 and USP7 (show USP7 Proteins) as factors that regulate DNA replication by controlling Geminin protein (show GMNN Proteins) stability, and suggest that USP7 (show USP7 Proteins) may be involved in Geminin (show GMNN Proteins) dysregulation during breast cancer progression.

  2. We provide evidence that DUB3 proteins regulate YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activity by controlling the stability of the E3 ligase ITCH, the LATS kinases and the AMOT (show AMOT Proteins) family proteins. As a novel Hippo pathway regulator, DUB3 has the potential to act a tumor suppressor by limiting YAP (show YAP1 Proteins) activity.

  3. In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 (show HDAC2 Proteins) is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17.

  4. These data indicate that the Dub3 might be a valuable biomarker for the prediction of ovarian cancer prognosis and Dub3 inhibition might be a potential strategy for ovarian cancer treatment.

  5. Dub3 counteracts H2AX E3 ligases RNF8 and RNF168. Moreover, Dub3 and H2AX interact and Dub3 deubiquitinates H2AX in vitro.

  6. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review]

  7. As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation.

  8. human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation.

  9. Identifies DUB3 as being one of 30 genes with the most variable copy numbers in three human genomes.

USP17L2 Protein Profile

Protein Summary

Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Deubiquitination of CDC25A prevents its degradation by the proteasome during the G1/S and G2/M phases of the cell cycle and is required for cell-cycle progression. Has transforming capabilities on cell lines. May also function in cell apoptosis.

Gene names and symbols associated with USP17L2

  • deubiquitinating enzyme 3 (Dub3)
  • ubiquitin specific peptidase 17-like 2 (USP17L2)
  • ubiquitin specific peptidase 17-like E (Usp17le)
  • ubiquitin specific peptidase 17-like family member 2 (USP17L2)
  • DUB-3 protein
  • DUB3 protein
  • Dub6 protein
  • EG625530 protein
  • Gm6596 protein
  • USP17 protein
  • Usp17l2 protein

Protein level used designations for USP17L2

deubiquitinating enzyme 3 , ubiquitin specific peptidase 17-like 2 , deubiquitinating enzyme 17-like protein 2 , deubiquitinating enzyme 6 , deubiquitinating protein 3 , deubiquitinating protein 6 , ubiquitin carboxyl-terminal hydrolase 17 , ubiquitin carboxyl-terminal hydrolase 17-like protein 2 , ubiquitin thioesterase 17-like protein 2 , ubiquitin thiolesterase 17-like protein 2 , ubiquitin-specific-processing protease 17-like protein 2

109998 Mus musculus
695235 Macaca mulatta
625530 Mus musculus
377630 Homo sapiens
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