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UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002 [PubMed 12356907]).[supplied by OMIM, Mar 2008].. Additionally we are shipping UNC45B Antibodies (41) and many more products for this protein.
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UNC-45B and Hsp90 (show HSP90 Proteins) involved in sarcomere function
vertebrate Unc45 isoforms clearly demonstrates a direct role for Unc45 in Hsp90-mediated myosin motor domain folding and highlights major differences between the isoforms in substrate specificity and mechanism
mammalian Unc45b is a cytosolic protein that forms a stable complex with Hsp90, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding
We have characterized a human UNC45B mutation in a Danish family with autosomal dominant cataract developing in early childhood.
temperature-dependent structural changes in the UCS chaperone domain of UNC-45B that occur within a physiologically relevant heat-shock range.
The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
Results indicate co-expression and co-regulation of Unc45b and non-muscle myosins (NMMs) in myogenic tissue.
There is no functional redundancy between Unc45a (show UNC45A Proteins) and Unc45b in vivo.
Steif/Unc-45b interacts with the chaperone Hsp90a (show HSP90AA1 Proteins) in vitro. The two genes are co-expressed in the skeletal musculature.
In response to stress or damage to the myofiber, Unc45b and Hsp90a dissociate from the Z line and transiently associate with myosin.
Different genotypes of the CMYA4 gene are significantly associated with the backfat thickness of the area between sixth and seventh ribs (p < 0.05) and backfat thickness at the shoulder (p < 0.05).
UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002
unc-45 homolog B
, sarcomeric myosin heavy chain chaperone
, unc-45 homolog B (C. elegans)
, protein unc-45 homolog B-like
, cardiomyopathy associated 4
, protein unc-45 homolog B
, striated muscle UNC45
, UNC45-related protein
, cardiomyopathy-associated 4