Unc-45 Homolog B (C. Elegans) Proteins (UNC45B)

UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002 [PubMed 12356907]).[supplied by OMIM, Mar 2008].. Additionally we are shipping UNC45B Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse UNC45B UNC45B 217012 Q8CGY6
UNC45B 146862 Q8IWX7
Rat UNC45B UNC45B 303373  
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Top UNC45B Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

UNC45B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Unc-45 Homolog B (C. Elegans) (UNC45B) Interaction Partners

Mouse (Murine) Unc-45 Homolog B (C. Elegans) (UNC45B) interaction partners

  1. UNC-45B and Hsp90 (show HSP90 Proteins) involved in sarcomere function

  2. vertebrate Unc45 isoforms clearly demonstrates a direct role for Unc45 in Hsp90-mediated myosin motor domain folding and highlights major differences between the isoforms in substrate specificity and mechanism

  3. mammalian Unc45b is a cytosolic protein that forms a stable complex with Hsp90, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding

Human Unc-45 Homolog B (C. Elegans) (UNC45B) interaction partners

  1. We have characterized a human UNC45B mutation in a Danish family with autosomal dominant cataract developing in early childhood.

  2. temperature-dependent structural changes in the UCS chaperone domain of UNC-45B that occur within a physiologically relevant heat-shock range.

Zebrafish Unc-45 Homolog B (C. Elegans) (UNC45B) interaction partners

  1. The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models

  2. Results indicate co-expression and co-regulation of Unc45b and non-muscle myosins (NMMs) in myogenic tissue.

  3. There is no functional redundancy between Unc45a (show UNC45A Proteins) and Unc45b in vivo.

  4. Steif/Unc-45b interacts with the chaperone Hsp90a (show HSP90AA1 Proteins) in vitro. The two genes are co-expressed in the skeletal musculature.

  5. In response to stress or damage to the myofiber, Unc45b and Hsp90a dissociate from the Z line and transiently associate with myosin.

Pig (Porcine) Unc-45 Homolog B (C. Elegans) (UNC45B) interaction partners

  1. Different genotypes of the CMYA4 gene are significantly associated with the backfat thickness of the area between sixth and seventh ribs (p < 0.05) and backfat thickness at the shoulder (p < 0.05).

UNC45B Protein Profile

Protein Summary

UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002

Gene names and symbols associated with UNC45B

  • unc-45 myosin chaperone B S homeolog (unc45b.S)
  • unc-45 myosin chaperone B (unc45b)
  • unc-45 myosin chaperone B (UNC45B)
  • unc-45 myosin chaperone B (Unc45b)
  • AA445617 protein
  • cb393 protein
  • CMYA4 protein
  • D230041A13Rik protein
  • MGC80931 protein
  • SMUNC45 protein
  • Unc-45B protein
  • UNC45 protein
  • unc45r protein
  • wu:fa05a03 protein
  • wu:fa10f03 protein
  • wu:fb37f02 protein
  • wu:fb96f06 protein
  • wu:fc10f04 protein

Protein level used designations for UNC45B

unc-45 homolog B , sarcomeric myosin heavy chain chaperone , unc-45 homolog B (C. elegans) , protein unc-45 homolog B-like , UNC-45B , cardiomyopathy associated 4 , protein unc-45 homolog B , striated muscle UNC45 , UNC45-related protein , fb37f02 , unc-45B , cardiomyopathy-associated 4

447296 Xenopus laevis
493194 Xenopus (Silurana) tropicalis
715419 Macaca mulatta
100483697 Ailuropoda melanoleuca
100586571 Nomascus leucogenys
217012 Mus musculus
146862 Homo sapiens
303373 Rattus norvegicus
480606 Canis lupus familiaris
100715234 Cavia porcellus
266640 Danio rerio
535385 Bos taurus
417527 Gallus gallus
100058135 Equus caballus
100134956 Sus scrofa
100346230 Oryctolagus cuniculus
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