Unc-5 Homolog D (C. Elegans) Proteins (UNC5D)

Receptor for netrin. Additionally we are shipping UNC5D Antibodies (44) and UNC5D Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat UNC5D UNC5D 306534  
UNC5D 137970 Q6UXZ4
Mouse UNC5D UNC5D 210801 Q8K1S2
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Top UNC5D Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

UNC5D Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,

More Proteins for Unc-5 Homolog D (C. Elegans) (UNC5D) Interaction Partners

Human Unc-5 Homolog D (C. Elegans) (UNC5D) interaction partners

  1. The authors identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores. Within this locus, the joint effects of two independent single nucleotide polymorphisms had a p-value of 4.38 x 10(-9) for mental composite scores.

  2. Unc5D is thus a newly identified transcriptional target of proapoptotic p53 (show TP53 Proteins) and may also act upstream of p53 (show TP53 Proteins) to induce p53dependent apoptosis by phosphorylation at ser15.

  3. the dependence receptor UNC5H4 may act as a putative tumor suppressor in neuroblastoma (show ARHGEF16 Proteins).

  4. UNC5D is a functional tumor suppressor that is frequently downregulated in RCCs due to promoter hypermethylation and LOH.

  5. UNC5D forms a positive feedback loop with p53 (show TP53 Proteins) and E2F1 (show E2F1 Proteins) to promote NGF (show NGFB Proteins) dependence-mediated programmed cell death during neuroblastoma (show ARHGEF16 Proteins) regression.

  6. UNC5H4 amplifies p53 (show TP53 Proteins)-dependent apoptotic response.

Mouse (Murine) Unc-5 Homolog D (C. Elegans) (UNC5D) interaction partners

  1. Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2 (show FLRT2 Proteins)-mediated cell adhesion.

  2. Unc5d is primarily expressed by layer 4 cells in the primary sensory areas of the developing neocortex and may mediate the effect of netrin-4 (show NTN4 Proteins) on cortical cell survival in a lamina-specific manner.

  3. Unc5h4 was cloned; its expression is in the developing limb and mammary gland in developing mouse

  4. UNC5D protein and nuclear RNA is localized in the multipolar cells of the subventricular zone throughout cortical development.

UNC5D Protein Profile

Protein Summary

Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

Gene names and symbols associated with UNC5D

  • unc-5 netrin receptor D (Unc5d)
  • unc-5 netrin receptor D (UNC5D)
  • unc-5 netrin receptor D (unc5d)
  • unc-5 homolog D (C. elegans) (unc5d)
  • D930029E11Rik protein
  • mKIAA1777 protein
  • PRO34692 protein
  • UNC5D protein
  • Unc5h4 protein

Protein level used designations for UNC5D

netrin receptor UNC5D , unc-5 homolog D (C. elegans) , netrin receptor Unc5h4 , netrin receptor UNC5D-like , protein unc-5 homolog 4 , protein unc-5 homolog D , unc-5 homolog 4 , unc5 homolog 4

306534 Rattus norvegicus
426920 Gallus gallus
472737 Pan troglodytes
482857 Canis lupus familiaris
520004 Bos taurus
697619 Macaca mulatta
100058060 Equus caballus
100339802 Oryctolagus cuniculus
100412764 Callithrix jacchus
100447821 Pongo abelii
100471265 Ailuropoda melanoleuca
100490873 Xenopus (Silurana) tropicalis
100534686 Danio rerio
100555483 Anolis carolinensis
100593116 Nomascus leucogenys
137970 Homo sapiens
210801 Mus musculus
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