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Unc-51 Like Kinase 2 (C. Elegans) Proteins (ULK2)

ULK2 encodes a protein that is similar to a serine/threonine kinase in C. Additionally we are shipping ULK2 Antibodies (128) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ULK2 9706 Q8IYT8
ULK2 303206  
ULK2 29869 Q9QY01
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Top ULK2 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

ULK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Rat (Rattus)
Mouse (Murine)

More Proteins for Unc-51 Like Kinase 2 (C. Elegans) (ULK2) Interaction Partners

Human Unc-51 Like Kinase 2 (C. Elegans) (ULK2) interaction partners

  1. miR (show MLXIP Proteins)-26b was down-regulated in LNCaP, DU145, C4-2 and PC-3 (show PCSK1 Proteins) cells compared to the two normal prostate cells RWPE-1 and WPMY-1 except DU145 cells. This inversely correlates with ULK2 level in the same cell lines.

  2. a novel signaling pathway identified whereby starvation-induced activation of ULK leads to phosphorylation of endogenous DENND3, with subsequent activation of Rab12 and initiation of membrane trafficking events required for autophagy

  3. Kapbeta2 interacts with ULK2 through ULK2's putative PY-NLS (show ALDH1A2 Proteins) motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity.

  4. Glioblastoma and glioma cell lines had low levels of ULK2 transcripts. ULK2 promoter methylation and transcript levels showed significant negative correlation.

  5. First identification and naming of ULK2 as an ortholog of mouse ULK2.

  6. In response to DNA damage, ULK1 (show ULK1 Proteins) and ULK2 are upregulated by p53 (show TP53 Proteins). The upregulation of ULK1 (show ULK1 Proteins) (ULK2)/ATG13 (show ATG13 Proteins) complex by p53 (show TP53 Proteins) is necessary for the sustained autophagy activity induced by DNA damage.

  7. The ULK-Atg13 (show ATG13 Proteins)-FIP200 complexes are direct targets of mTOR (show FRAP1 Proteins) and important regulators of autophagy in response to mTOR (show FRAP1 Proteins) signaling.

Mouse (Murine) Unc-51 Like Kinase 2 (C. Elegans) (ULK2) interaction partners

  1. autophagy can be executed by mechanisms that are dependent or independent of the ULK1 (show ULK1 Proteins)/2-ATG13 (show ATG13 Proteins) interaction.

  2. AnxA2 (show ANXA2 Proteins) regulates autophagy, thereby contributing to host immunity against bacteria through the Akt1 (show AKT1 Proteins)-mTOR (show FRAP1 Proteins)-ULK1 (show ULK1 Proteins)/2 signaling pathway

  3. ULK2 induced autophagy and inhibited growth in Ras-transformed immortalized Baby Mouse Kidney (iBMK) ATG5(+/+) but not in autophagy-deficient ATG5(-/-) cells.

  4. Ulk1 (show ULK1 Proteins) knockdown reduced fatty acid oxidation and enhanced fatty acid uptake, the metabolic changes that could contribute to adipogenesis, whereas Ulk2 knockdown had opposing effects.

  5. Analysis of the autophagy signaling pathway showed the existence of a negative feedback loop between the ULK1 (show ULK1 Proteins) and 2 and MTORC1 and 2, in lung tissue.

  6. ULK1 (show ULK1 Proteins) and ULK2 have redundant roles in nutrient-dependent activation of autophagy

  7. ULK1 (show ULK1 Proteins) and ULK2 are functionally redundant protein kinases required to mediate autophagy under nutrient-deprived conditions in fibroblasts.

  8. the autophagy response to the enhanced amino acid catabolism induced by deprivation of glucose or direct exposure to ammonia does not require ULK1 (show ULK1 Proteins) and/or ULK2

  9. ULK2, by interaction with FRS2 (show FRS2 Proteins)/3 and inhibition of SynGAP (show SYNGAP1 Proteins), functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1 (show FGFR1 Proteins).

  10. ULK2 is localized to vesicular structures in growth cones of spinal ganglia afferent neurons. RNAi-mediated knockdown of ULK2 resulted in impaired endocytosis of nerve growth factor, excessive axon arborization, and severely stunted axon elongation.

Zebrafish Unc-51 Like Kinase 2 (C. Elegans) (ULK2) interaction partners

  1. Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of dendrites

ULK2 Protein Profile

Protein Summary

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with ULK2

  • unc-51-like kinase 2 (C. elegans) (ULK2)
  • unc-51 like autophagy activating kinase 2 (ULK2)
  • unc-51 like autophagy activating kinase 2 (Ulk2)
  • unc-51 like kinase 2 (Ulk2)
  • unc-51-like kinase 2 (C. elegans) (ulk2)
  • A830085I22Rik protein
  • ATG1B protein
  • AU015340 protein
  • mKIAA0623 protein
  • ULK2 protein
  • Unc51.2 protein

Protein level used designations for ULK2

unc-51-like kinase 2 (C. elegans) , serine/threonine-protein kinase ULK2 , Unc-51 like kinase 2 , serine/threonine-protein kinase Unc51.2 , unc-51-like kinase 2

417614 Gallus gallus
454507 Pan troglodytes
618601 Bos taurus
9706 Homo sapiens
303206 Rattus norvegicus
29869 Mus musculus
100329702 Danio rerio
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