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Voltage-Dependent Anion Channel 1 Proteins (VDAC1)

VDAC1 encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. Additionally we are shipping VDAC1 Antibodies (173) and VDAC1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VDAC1 7416 P21796
Rat VDAC1 VDAC1 83529 Q9Z2L0
Mouse VDAC1 VDAC1 22333 Q60932
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Top VDAC1 Proteins at

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human GST tag,His tag   100 μg Log in to see 11 to 13 Days

VDAC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Voltage-Dependent Anion Channel 1 (VDAC1) Interaction Partners

Arabidopsis thaliana Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Abnormal ovules in the process of female gametogenesis were observed. Both mitochondrial transmembrane potential and ATP synthesis rate were obviously reduced in the mitochondria isolated from atvdac1 plants.

  2. Data indicate that both voltage-dependent anion channel 1 (AtVDAC1) and calcium sensor CBL1 regulate cold stress responses during seed germination and plant development.

  3. AtVDAC1 has a main function in mitochondria

  4. VDAC1 is not only necessary for normal growth but also important for disease resistance through regulation of hydrogen peroxide generation.

Human Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. The findings of this study suggest that inhibition of intracellular Ca(2 (show CA2 Proteins)+/-) overload could protect cells from damage and that VDAC1 plays a considerable role in Cr(VI)-induced liver injury.

  2. Our study suggested that miR-7 (show LILRB1 Proteins) suppressed the expression of VDAC1 in hepatocellular carcinoma

  3. Results shows that beta-barrel of human VDAC1 embedded into a membrane is highly flexible and that Ca2+, a key regulator of metabolism and apoptosis, strongly decreases its plasticity suggesting that physiological VDAC function depends on the molecular plasticity of its channel.

  4. High VDAC1 expression is associated with cervical cancer.

  5. Studies using B16F10 and A375 cells genetically modified for ATF2 (show ATF2 Proteins) indicated that mitochondrial ATF2 (show ATF2 Proteins) was able to dissociate Bim (show BCL2L11 Proteins) from the Mcl-1 (show MCL1 Proteins)/Bim (show BCL2L11 Proteins) complex to trigger VDAC1 oligomerization.

  6. findings also suggest that VDAC1 may be a novel biomarker for gastric cancer

  7. serum starvation induces CREB1 (show CREB1 Proteins) expression, in turn activating miR (show MLXIP Proteins)-320a expression, which then down-regulates VDAC1 expression to facilitate mitophagy

  8. Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in glioblastoma multiforme cancer cell differentiation.

  9. The works available on VDAC cysteines support the notion that VDAC1, VDAC2, and VDAC3 proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)

  10. The protective effect of miR-7 (show LILRB1 Proteins) is partly exerted through promoting mitochondrial function by targeting VDAC1 expression.

Pig (Porcine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Data confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.

Cow (Bovine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.

  2. Suggest that VDAC1 participates in volume regulatory processes in spermatozoa.

Mouse (Murine) Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. VDAC1-interacting anion transport inhibitors inhibited apoptosis via direct interaction with VDAC1 to inhibit its oligomerization and subsequent Cyto c release and apoptosis.

  2. Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in glioblastoma multiforme cancer cell differentiation.

  3. TSPO (show TSPO Proteins) as a novel element in the regulation of mitochondrial quality control by autophagy, and demonstrate the importance for cell homeostasis of its expression ratio with voltage-dependent anion channel 1

  4. ATP flows through VDAC through multiple pathways, in agreement with our structural data and experimentally determined physiological rates.

  5. Reduced VDAC1 expression protects against Alzheimer's disease and synaptic deficiencies.

  6. Data suggest presence of unstructured C-terminal tubulin (show TUBB Proteins) tail in VDAC pore decreases conductance and switches selectivity from anionic to cationic rendering ATP transport virtually impossible; involves stable salt bridge (K336-tubulin (show TUBB Proteins)/D186-Vdac1).

  7. MAVS (show MAVS Proteins) binds to voltage-dependent anion channel 1 (VDAC1) and induces apoptosis by caspase-3 (show CASP3 Proteins) activation, which is independent of its role in innate immunity.

  8. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.

  9. Flexibility of the N-terminal mVDAC1 segment controls the channel's gating behavior.

  10. the N-terminal alpha-helix is located inside the pore of VDAC in the open state and remains associated with beta-strand 11 of the pore wall during voltage gating

Zebrafish Voltage-Dependent Anion Channel 1 (VDAC1) interaction partners

  1. we found that Bcl-wav controls intracellular Ca(2+) trafficking by acting on the mitochondrial voltage-dependent anion channel, and possibly on MCU, with direct consequences on actin microfilament dynamics and blastomere migration guidance.

VDAC1 Protein Profile

Protein Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.

Gene names and symbols associated with VDAC1

  • voltage-dependent anion channel 1 (vdac1)
  • voltage-dependent anion channel 1 (VDAC1)
  • voltage dependent anion channel 1 (VDAC1)
  • voltage-dependent anion channel 1 (Vdac1)
  • 5076 protein
  • AL033343 protein
  • ATVDAC1 protein
  • fa13f11 protein
  • PORIN protein
  • T22N4.9 protein
  • T22N4_9 protein
  • VDAC-1 protein
  • VDAC1 protein
  • Vdac5 protein
  • voltage dependent anion channel 1 protein
  • wu:fa13f11 protein
  • zgc:85830 protein

Protein level used designations for VDAC1

voltage-dependent anion channel 1 , outer mitochondrial membrane protein porin 1 , plasmalemmal porin , porin 31HL , porin 31HM , voltage-dependent anion-selective channel protein 1 , VDAC-1 , rVDAC1 , BR1-VDAC , brain-derived voltage-dependent anion channel 1 , VDAC-5 , mVDAC1 , mVDAC5 , voltage-dependent anion-selective channel protein 5

380376 Xenopus laevis
549246 Xenopus (Silurana) tropicalis
745717 Pan troglodytes
820914 Arabidopsis thaliana
7416 Homo sapiens
83529 Rattus norvegicus
397010 Sus scrofa
282119 Bos taurus
100008751 Oryctolagus cuniculus
22333 Mus musculus
334582 Danio rerio
474681 Canis lupus familiaris
100145866 Ovis aries
100723897 Cavia porcellus
416320 Gallus gallus
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