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Von Willebrand Factor Proteins (VWF)

The glycoprotein encoded by VWF functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. Additionally we are shipping VWF Antibodies (497) and VWF Kits (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VWF 7450 P04275
VWF 116669  
VWF 22371 Q8CIZ8
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Top VWF Proteins at

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_CHO Cells Human His tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Wild boar His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   100 μg Log in to see 7 to 9 Days

VWF Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Rat (Rattus) ,

Mouse (Murine)

Top referenced VWF Proteins

  1. Human VWF Protein expressed in CHO Cells - ABIN2003667 : Nogami, Shima, Nishiya, Hosokawa, Saenko, Sakurai, Shibata, Suzuki, Tanaka, Yoshioka: A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation. in Blood 2002 (PubMed)
    Show all 4 references for ABIN2003667

More Proteins for Von Willebrand Factor (VWF) Interaction Partners

Human Von Willebrand Factor (VWF) interaction partners

  1. ADAMTS13 (show ADAMTS13 Proteins) is the key protease that regulates the multimeric state of VWF. Without ADAMTS13 (show ADAMTS13 Proteins), VWF multimers can grow to pathologically large sizes. This is a risk factor for the life-threatening condition thrombotic thrombocytopenic purpura (TTP (show ADAMTS13 Proteins))

  2. Stroke in human immunodeficiency virus infection is associated with a prothrombotic state, characterized by elevated von Willebrand factor and low ADAMTS13 (show ADAMTS13 Proteins) levels

  3. An in vitro model for LVAD associated aVWD demonstrated that ADAMTS-13 (show ADAMTS13 Proteins) and platelets contribute to the depletion of HMWM of VWF.

  4. free thiol groups are shown to be involved in VWF binding to both collagen III and platelet GP1b (show GP1BA Proteins) receptor.

  5. Large cohort of Spanish von Willebrand disease patients in whom VWF mutations have been identified.

  6. Type 2B mutations localized in the A1 domain could enhance the sensitivity to ADAMTS13 (show ADAMTS13 Proteins)-mediated proteolysis. When GPIbalpha (show GP1BA Proteins) participated, there was a dramatically increased proteolytic cleavage of VWF by ADAMTS13 (show ADAMTS13 Proteins) to rVWF-WT, excluding some type 2B mutants.

  7. Study compared the force-induced domain unfolding of recombinant dimeric VWF with recombinant VWF multimers

  8. Glycan stabilization of the VWF A2 domain acts together with the Ca(2 (show CA2 Proteins)+)binding site and vicinal cysteine disulfide bond to control unfolding and ADAMTS13 (show ADAMTS13 Proteins) proteolysis.

  9. Based on prediction scores, four variants, namely, P1266L, H1268D, C1272R, and C1272F, were predicted as highly deleterious from a pool of 72 nsSNPs/variants in A1 domain of VWD belonging to type 2A and 2B

  10. Interaction between VWF and FVIII (show F8 Proteins) in treating VWD.

Pig (Porcine) Von Willebrand Factor (VWF) interaction partners

  1. alterations in glycosylation of vWF and other adhesion proteins associated with the targeting of the alpha1,3-Gal (show GAL Proteins)-epitope in mutant swine may have salutatory effects on the primate platelet activation observed in these xenografts.

Cow (Bovine) Von Willebrand Factor (VWF) interaction partners

  1. Hemodynamic activation of vWF and increased plasma ADAMTS-13 (show ADAMTS13 Proteins) may have contributed to reduced high-molecular-weight vWF multimers and impairment of the vWF-platelet aggregation pathway during mechanical circulatory support.

  2. both the gpIb-VWF interaction and the integrin alpha(2 (show ITGA2 Proteins))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Proteins))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound

Mouse (Murine) Von Willebrand Factor (VWF) interaction partners

  1. Staphylococcus lugdunensis binds directly to von Willebrand factor, which proved to be vital for withstanding shear forces and for its adhesion to the vessel wall and cardiac valves.

  2. Clinical experimental cerebral malaria progression was delayed, and overall survival was significantly prolonged in VWF(-/-) mice compared with WT controls.

  3. in stable compensated heart failure mice, disruptions in endothelial vWF expression and extrusion may reduce the incidence of endocardial thrombosis

  4. VWF is expressed in a mosaic pattern in the capillaries of many vascular beds and in the aorta. Hearts of VWF-null mice demonstrate an abnormal endothelial phenotype as well as cardiac dysfunction.

  5. SNAP23 (show SNAP23 Proteins) Regulates Endothelial Exocytosis of von Willebrand Factor

  6. Both platelet-VWF and plasma-VWF are required for optimal platelet-derived FVIII (show F8 Proteins) gene therapy for hemophilia A in the presence of inhibitors.

  7. a genetic link between EGLN1 (show EGLN1 Proteins) and VWF in a constitution specific manner which could modulate thrombosis/bleeding susceptibility and outcomes of hypoxia, is reported.

  8. novel findings demonstrate a specific and critical role for the R1205 residue in modulating macrophage-mediated clearance of VWF in vivo

  9. Clearance differences between blood group (show DARC Proteins) O and non-blood group (show DARC Proteins) O individuals may therefore be related to the blood group (show DARC Proteins) status of the individual rather than the ABH (show ALKBH Proteins) antigen loading on VWF itself.

  10. Certain VWD-type 2B mutations relieve the need for shear stress to induce LRP1 (show LRP1 Proteins) binding. Enhanced LRP1 (show LRP1 Proteins) binding coincides with a reduced survival of VWF/p.R1306Q and VWF/p.V1316M

VWF Protein Profile

Protein Summary

The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22.

Gene names and symbols associated with Von Willebrand Factor Proteins (VWF)

  • von Willebrand factor (VWF)
  • von Willebrand factor (vwf)
  • von Willebrand factor (Vwf)
  • Von Willebrand factor homolog (Vwf)
  • 6820430P06Rik protein
  • AI551257 protein
  • B130011O06Rik protein
  • C630030D09 protein
  • F8VWF protein
  • si:ch1073-474e24.1 protein
  • VWD protein
  • VWF protein

Protein level used designations for Von Willebrand Factor Proteins (VWF)

von Willebrand factor , coagulation factor VIII VWF

451773 Pan troglodytes
493760 Felis catus
570643 Danio rerio
619381 Monodelphis domestica
722019 Macaca mulatta
7450 Homo sapiens
116669 Rattus norvegicus
399544 Canis lupus familiaris
100009165 Oryctolagus cuniculus
399543 Sus scrofa
280958 Bos taurus
100732530 Cavia porcellus
419031 Gallus gallus
101110931 Ovis aries
22371 Mus musculus
Selected quality suppliers for VWF Proteins (VWF)
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