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The glycoprotein encoded by VWF functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. Additionally we are shipping VWF Antibodies (494) and VWF Kits (69) and many more products for this protein.
Showing 10 out of 22 products:
Human VWF Protein expressed in CHO Cells - ABIN2003667
Nogami, Shima, Nishiya, Hosokawa, Saenko, Sakurai, Shibata, Suzuki, Tanaka, Yoshioka: A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation. in Blood 2002
Show all 4 references for ABIN2003667
Endothelial cell cycle and vWF expression and secretion affected by chronic lymphocytic leukemia plasma; NF-kappaB (show NFKB1 Proteins) plays a role in the process.
von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.
ADAMTS13 (show ADAMTS13 Proteins) and VWF are co-expressed in microvascular endothelial cells.
ADAMTS13 (show ADAMTS13 Proteins)-a disintegrin-like metalloproteinase with thrombospondin motif type 1 member 13-regulates a key physiological process of coagulation in the circulation by cleaving VWF multimers into small, inactive fragments. Low levels of ADAMTS13 (show ADAMTS13 Proteins) in the blood may play a role in cardiovascular and hematological disorders, and clarifying its role may help improve disease management.
von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.
von Willebrand factor and ADAMTS-13 (show ADAMTS13 Proteins) are associated with the occurrence of venous thromboembolism in patients with cancer.
REVIEW: VWF biosynthesis, maturation, and secretion is a complex process, which mandates tight regulation; significant progress has been made in our understandings of VWF expression and secretion and its association with thrombotic diseases
Serum HIF-1alpha (show HIF1A Proteins), VEGF (show VEGFA Proteins), vWf, and IGF-1 (show IGF1 Proteins) may be involved in diabetic kidney development by mediating inflammation, angiogenesis, and endothelial injury.
This brief review will highlight knowledge acquired and key problems that remain to be solved to elucidate fully the role of VWF in normal haemostasis and pathological thrombosis. [human]
data suggest that increased levels of VWF and reduced levels of ADAMTS13 (show ADAMTS13 Proteins) activity may contribute to the pathogenesis of cerebral infarction.
alterations in glycosylation of vWF and other adhesion proteins associated with the targeting of the alpha1,3-Gal (show GAL Proteins)-epitope in mutant swine may have salutatory effects on the primate platelet activation observed in these xenografts.
Hemodynamic activation of vWF and increased plasma ADAMTS-13 (show ADAMTS13 Proteins) may have contributed to reduced high-molecular-weight vWF multimers and impairment of the vWF-platelet aggregation pathway during mechanical circulatory support.
both the gpIb-VWF interaction and the integrin alpha(2 (show ITGA2 Proteins))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Proteins))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound
von Willebrand factor exerts beneficial effects in a mouse sepsis model via recruitment of neutrophils to inflammatory sites.
Staphylococcus lugdunensis binds directly to von Willebrand factor, which proved to be vital for withstanding shear forces and for its adhesion to the vessel wall and cardiac valves.
Clinical experimental cerebral malaria progression was delayed, and overall survival was significantly prolonged in VWF(-/-) mice compared with WT controls.
in stable compensated heart failure mice, disruptions in endothelial vWF expression and extrusion may reduce the incidence of endocardial thrombosis
VWF is expressed in a mosaic pattern in the capillaries of many vascular beds and in the aorta. Hearts of VWF-null mice demonstrate an abnormal endothelial phenotype as well as cardiac dysfunction.
SNAP23 (show SNAP23 Proteins) Regulates Endothelial Exocytosis of von Willebrand Factor
Both platelet-VWF and plasma-VWF are required for optimal platelet-derived FVIII (show F8 Proteins) gene therapy for hemophilia A in the presence of inhibitors.
a genetic link between EGLN1 (show EGLN1 Proteins) and VWF in a constitution specific manner which could modulate thrombosis/bleeding susceptibility and outcomes of hypoxia, is reported.
novel findings demonstrate a specific and critical role for the R1205 residue in modulating macrophage-mediated clearance of VWF in vivo
Clearance differences between blood group (show DARC Proteins) O and non-blood group (show DARC Proteins) O individuals may therefore be related to the blood group (show DARC Proteins) status of the individual rather than the ABH (show ALKBH Proteins) antigen loading on VWF itself.
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22.
von Willebrand factor
, coagulation factor VIII VWF