WD Repeat Domain 48 Proteins (WDR48)

Regulator of deubiquitinating complexes. Additionally we are shipping WDR48 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WDR48 57599 Q8TAF3
Mouse WDR48 WDR48 67561 Q8BH57
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Top WDR48 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Insect cells (Sf21) Human His tag   50 μg Log in to see 5 to 8 Days
$568.05
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WDR48 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for WD Repeat Domain 48 (WDR48) Interaction Partners

Human WD Repeat Domain 48 (WDR48) interaction partners

  1. UAF1 and WDR20 (show WDR20 Proteins) interact with USP12 (show USP12 Proteins) at two distinct sites far from its catalytic center, allosterically activating the enzyme.

  2. USP1 (show USP1 Proteins)-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1 (show RAD51AP1 Proteins).

  3. analysis of the function and regulation of the USP1 (show USP1 Proteins)-UAF1 complex

  4. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1 (show USP1 Proteins), USP12 (show USP12 Proteins) and USP46 (show USP46 Proteins).

  5. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival.

  6. Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1

  7. USP1 (show USP1 Proteins) and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 (show USP1 Proteins) nuclear localization signals.

  8. p80 (show COIL Proteins) is recruited to the viral origin in an E1- and E2-dependent manner.

  9. WDR20 (show WDR20 Proteins) serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 (show USP12 Proteins) complexes

  10. These findings suggest that the interaction of human papillomavirus 11 and 31 E1 proteins with p80 (show COIL Proteins) is required for efficient maintenance of the viral episome in undifferentiated keratinocytes.

WDR48 Protein Profile

Protein Summary

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2\; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes (By similarity).

Gene names and symbols associated with WD Repeat Domain 48 Proteins (WDR48)

  • WD repeat domain 48 (WDR48)
  • WD repeat domain 48 (Wdr48)
  • 8430408H12Rik protein
  • mKIAA1449 protein
  • P80 protein
  • UAF1 protein

Protein level used designations for WD Repeat Domain 48 Proteins (WDR48)

USP1 associated factor 1 , USP1-associated factor 1 , WD repeat endosomal protein , WD repeat-containing protein 48

GENE ID SPECIES
57599 Homo sapiens
67561 Mus musculus
618860 Bos taurus
420427 Gallus gallus
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