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WDR5 encodes a member of the WD repeat protein family. Additionally we are shipping WDR5 Antibodies (100) and WDR5 Proteins (20) and many more products for this protein.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (show MSH2 ELISA Kits) gene expression.
WDR5 over-expression is associated with poor breast cancer clinical outcome.
Results identify WDR5 as a key cofactor for N-Myc (show MYCN ELISA Kits)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (show MYCN ELISA Kits)-amplified neuroblastomas.
BIG3 may block the KPNAs (KPNA1 (show KPNA1 ELISA Kits), KPNA5 (show KPNA5 ELISA Kits), and KPNA6 (show KPNA6 ELISA Kits)) binding region(s) of PHB2 (show PHB2 ELISA Kits).
solution structures of the MLL3 core complex assembled with and without WDR5 by small angle x-ray scattering show similar overall topologies
Target gene recognition by MYC (show MYC ELISA Kits) depends on its interaction with WDR5. This interaction could create an avidity-based chromatin recognition mechanism allowing MYC (show MYC ELISA Kits) to select its target genes in response to both genetic and epigenetic determinants. Review.
we have discovered that WDR5 plays an important role in bladder cancer suggesting that WDR5 is a potential biomarker and a promising target in the treatment of bladder cancer.
Wdr5-MLL (show MLL ELISA Kits) interaction in C/EBPA (show CEBPA ELISA Kits) N-terminal leukemia is a promising pharmacological target.
findings prove that the TSP-1 (show THBS1 ELISA Kits)/CD47 (show CD47 ELISA Kits)/SIRP (show SIRPA ELISA Kits)-alpha signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 (show THBS1 ELISA Kits) as a key signal
results identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation and as a major driver of androgen-dependent prostate cancer cell proliferation
BIG3(WRD5)-PHB2 (show PHB2 ELISA Kits) interaction is critical for the tamoxifen resistance of breast cancer cells; its targeting reverses the resistance.
Wdr5 suppression also reduced IFNgamma, Il-1beta (show IL1B ELISA Kits), and TNFalpha (show TNF ELISA Kits) induced chemokine (show CCL1 ELISA Kits) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL (show MLL ELISA Kits) complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (show MYC ELISA Kits) with chromatin depends on interaction with the WD40 (show DCAF12L2 ELISA Kits)-repeat protein WDR5.
BIG3 inhibits insulin (show INS ELISA Kits) granule biogenesis and insulin (show INS ELISA Kits) secretion.
BIG3 negatively regulates insulin (show INS ELISA Kits) granule exocytosis by restricting insulin (show INS ELISA Kits) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (show KAT2B ELISA Kits) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (show DYM ELISA Kits)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 (show RBBP5 ELISA Kits) through a conserved motif to enhance methylation of histone H3 (show HIST3H3 ELISA Kits) lysine 4 by mixed lineage leukemia protein-1.
WDR5 is essential in assembling a virus-induced VISA (show MAVS ELISA Kits)-associated complex and plays an important role in virus-triggered induction of type I interferons.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
WD repeat domain 5
, WD repeat-containing protein 5
, BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD-repeat protein 5
, WD repeat-containing protein BIG-3