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WT1 encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. Additionally we are shipping WT1 Antibodies (220) and WT1 Kits (11) and many more products for this protein.
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WT1 interference with Wnt (show WNT2 Proteins) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
WT1 gene expression is associated with a poor outcome for patients showing non-MYCN (show MYCN Proteins)-amplified neuroblastoma (show ARHGEF16 Proteins) tumors.
High WT1 gene expression is associated with Acute Myeloid Leukemia (show BCL11A Proteins).
HuR (show ELAVL1 Proteins) binds to the pyrimidine-rich sequence and antagonize its effect in regulating WT1 +/-KTS isoforms.
High WT1 expression is associated with colorectal cancer.
The developmental expression regulation of WT1 protein in the human fetal heart has been presented.
WT1 rs16754 polymorphism in AML (show RUNX1 Proteins) could influence the standard chemotherapy effectiveness, specifically the variant allele (G) could be associated with increased overall survival. [meta-analysis]
High WT1 expression levels are associated with Acute Leukemia.
The novel mutant p. P126S and p. R370H in the WT1 gene potentially impaired GCs (show GCLC Proteins) differentiation and oocyte-GCs (show GCLC Proteins) interaction, which might result in loss of follicles prematurely. Therefore, WT1 is a plausible causal gene for POF (show POF1B Proteins).
Data show that Wilms' tumor 1 protein (WT1)binds to the zinc finger protein 224 (ZNF224 (show ZNF224 Proteins)) promoter and represses ZNF224 (show ZNF224 Proteins) expression.
We present WT1 as a robust prognostic marker in high-grade serous ovarian carcinoma, which adds prognostic information to ER-alpha (show ESR1 Proteins) and should be kept in mind when WT1 is used as a biomarker in the context of WT1-targeting therapies.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
miR (show MLXIP Proteins)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR of WT1 mRNA and miR (show MLXIP Proteins)-125a knockout mice induce myeloproliferative disease (MPD (show MVD Proteins)) and urogenital abnormalities
The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.
During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21 (show TCF21 Proteins)-LacZ (show GLB1 Proteins) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.
Wt1 is essential for normal development at all kidney developmental stages under study.
Wt1 expression levels in podocytes regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling through modulating the endocytic fate of LRP6 (show LRP6 Proteins), and this indicates a potential target for the therapy of CKD.
The results suggest a possible role for Wt1 in cardiac vessel formation in development and disease.
Conditional beta-catenin (show CTNNB1 Proteins) loss phenocopies the Wt1 mutant diaphragm defect, while constitutive activation of beta-catenin (show CTNNB1 Proteins) on the Wt1 mutant background is sufficient to close the diaphragm defect
WT1 modulates receptor tyrosine kinase (show ERBB3 Proteins) signaling in nephron progenitor cell by directing the expression of Gas1 (show GAS1 Proteins).
WT1 can modulate LHbeta (show LHB Proteins) transcription with differential roles for the two WT1 variants
the results of this study demonstrate a novel association between fibrocyte-driven WT1(+) cell accumulation and severe fibrotic lung disease.
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Wilm's tumor suppressor
, Wilms tumor protein homolog B
, Chick Wilm's tumour protein
, Wilms tumor suppressor protein 1b