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WT1 encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. Additionally we are shipping WT1 Antibodies (222) and WT1 Kits (11) and many more products for this protein.
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WT1 interference with Wnt (show WNT2 Proteins) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
WT1 was significantly under-expressed in testicular germ cell tumors. WT1 mutations occur frequently in testicular germ cell tumors.
The WT1 mRNA expression level is elevated in myelodysplastic syndrome patients at diagnosis, and it may be a significant independent prognostic marker for elderly patients with this disease.
It is highly probable that the WT1 mRNA expression level is, to some extent, associated with the percentage of blasts in myelodysplastic syndromes patients.
WT1 and NPHS2 gene mutation analysis and clinical management of steroid-resistant nephrotic syndrome.
we identified gene promoter methylation signatures (WT1, MSH6 (show MSH6 Proteins), GATA5 (show GATA5 Proteins) and PAX5 (show PAX5 Proteins)) that are strongly correlated to, and can have a predictive value for the clinical outcome of oral squamous cell carcinoma patients
Positive staining of WT1 in tumor cells was observed in 25.3% of cancer patients, with only 8.5% of them showing moderate to strong expression; moreover, WT1 tended to localize in the nucleus and cytoplasm.
New WT1 mutations/polymorphisms identified in boys with sporadic isolated steroid-resistant nephrotic syndrome and in controls.
The results indicate that the tumorigenesis of MDS (show PAFAH1B1 Proteins) is likely to originate at the stem cell level, suggesting that the WT1 mRNA level measurement in the BM is an effective prognostic marker in patients with MDS (show PAFAH1B1 Proteins).
Immunotherapy using WT1 antigen has been effective in stimulating immune responses against leukemic cells. Regarding adoptive immunotherapy, the use of dendritic cells (DCs) for the WT1-specific cytotoxic T cells generation proved to be efficient in the development and maintenance of immunologic cells
WT1 gene mutations are a predictor indicator of a poor prognosis factor in CN-AML (show RUNX1 Proteins) patients.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
miR (show MLXIP Proteins)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR of WT1 mRNA and miR (show MLXIP Proteins)-125a knockout mice induce myeloproliferative disease (MPD (show MVD Proteins)) and urogenital abnormalities
The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.
During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21 (show TCF21 Proteins)-LacZ (show GLB1 Proteins) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.
Wt1 is essential for normal development at all kidney developmental stages under study.
Wt1 expression levels in podocytes regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling through modulating the endocytic fate of LRP6 (show LRP6 Proteins), and this indicates a potential target for the therapy of CKD.
The results suggest a possible role for Wt1 in cardiac vessel formation in development and disease.
Conditional beta-catenin (show CTNNB1 Proteins) loss phenocopies the Wt1 mutant diaphragm defect, while constitutive activation of beta-catenin (show CTNNB1 Proteins) on the Wt1 mutant background is sufficient to close the diaphragm defect
WT1 modulates receptor tyrosine kinase (show ERBB3 Proteins) signaling in nephron progenitor cell by directing the expression of Gas1 (show GAS1 Proteins).
WT1 can modulate LHbeta (show LHB Proteins) transcription with differential roles for the two WT1 variants
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Wilm's tumor suppressor
, Wilms tumor protein homolog B
, Chick Wilm's tumour protein
, Wilms tumor suppressor protein 1b