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Wilms Tumor 1 Proteins (WT1)

WT1 encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. Additionally we are shipping WT1 Antibodies (279) and WT1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WT1 7490 P19544
Rat WT1 WT1 24883 P49952
Mouse WT1 WT1 22431  
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Top WT1 Proteins at

Showing 6 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days

WT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Wilms Tumor 1 (WT1) Interaction Partners

Xenopus laevis Wilms Tumor 1 (WT1) interaction partners

  1. WT1 interference with Wnt (show WNT2 Proteins) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.

Human Wilms Tumor 1 (WT1) interaction partners

  1. Predictive value of pretransplantation molecular minimal residual disease assessment by WT1 gene expression in FLT3 (show FLT3 Proteins)-positive acute myeloid leukemia (show BCL11A Proteins).

  2. Wilms' tumor 1 is expressed in endometrial intra-epithelial neoplasia. Cellular endometrial intra-epithelial neoplasia Wilms' tumor 1 positivity was 100% and vascular Wilms' tumor 1 positivity was 85%. The endometrial adenocarcinoma group had 67% cellular Wilms' tumor 1 positivity and 73% vascular positivity.

  3. WT1 localizes to the cytoplasm and mirn16-1 is decreased in nephrotic syndrome

  4. WTI expression correlates with disease status both at the time of diagnosis and then different phases of the treatment. High WT1 burden in both these patients is indicative of early recurrence of the disease along with shorter disease-free and overall survival. The low WT1 expression (< 200 copies/ml) in 2 patients after induction and consolidation therapy respectively was suggestive of better prognosis.

  5. miR (show MLXIP Proteins)-361 was downregulated in NSCLC tissues and cell lines. Ectopic expression of miR (show MLXIP Proteins)-361 suppressed the proliferation, migration and invasion of NSCLC cells via the direct targeting of WT1.

  6. the results indicate that the cytoplasmic immunostaining does not correlate with actual WT1 expression and prompts researchers to carefully evaluate target molecule expression in treatment of cancer.

  7. The Correlation between GATA5 (show GATA5 Proteins), WT1 and PAX5 (show PAX5 Proteins) methylation and clinical/histological parameters is suggestive of applicability of these markers in non-invasive (epi (show TFPI Proteins))genetic testing in hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  8. WT1 is often highly expressed in benign non-oncocytic salivary tumors whereas the malignant tumors show decreased expression, the exception being PLGA.

  9. High WT1 expression is associated with leukemia.

  10. WT1 was significantly under-expressed in testicular germ cell tumors. WT1 mutations occur frequently in testicular germ cell tumors.

Pig (Porcine) Wilms Tumor 1 (WT1) interaction partners

  1. Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.

  2. Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.

  3. WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts

Mouse (Murine) Wilms Tumor 1 (WT1) interaction partners

  1. Over expression of miR (show MLXIP Proteins)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (show MLXIP Proteins)-206 may be a potential therapeutic target.

  2. by targeting WT1, miR743a suppresses the proliferation of MM cells in vitro, and probably possesses vital functions in kidney development and kidneyassociated diseases.

  3. To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors

  4. miR (show MLXIP Proteins)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR of WT1 mRNA and miR (show MLXIP Proteins)-125a knockout mice induce myeloproliferative disease (MPD (show MVD Proteins)) and urogenital abnormalities

  5. The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.

  6. During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21 (show TCF21 Proteins)-LacZ (show GLB1 Proteins) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.

  7. Wt1 is essential for normal development at all kidney developmental stages under study.

  8. Wt1 expression levels in podocytes regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling through modulating the endocytic fate of LRP6 (show LRP6 Proteins), and this indicates a potential target for the therapy of CKD.

  9. The results suggest a possible role for Wt1 in cardiac vessel formation in development and disease.

  10. Conditional beta-catenin (show CTNNB1 Proteins) loss phenocopies the Wt1 mutant diaphragm defect, while constitutive activation of beta-catenin (show CTNNB1 Proteins) on the Wt1 mutant background is sufficient to close the diaphragm defect

Zebrafish Wilms Tumor 1 (WT1) interaction partners

  1. While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.

WT1 Protein Profile

Protein Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Gene names and symbols associated with Wilms Tumor 1 Proteins (WT1)

  • Wilms tumor 1 (WT1)
  • Wilms tumor 1 (wt1-a)
  • Wilms tumor 1 (wt1)
  • Wilms tumor 1 (LOC100346776)
  • Wilms tumor protein (wt1)
  • Wilms tumor 1 (wt1-b)
  • Wilms tumor 1 (Wt1)
  • Wilms tumor 1 homolog (Wt1)
  • wilms tumor 1b (wt1b)
  • AWT1 protein
  • CWT1 protein
  • D630046I19Rik protein
  • EWS-WT1 protein
  • GUD protein
  • NPHS4 protein
  • si:ch211-160j6.3 protein
  • WAGR protein
  • WIT-2 protein
  • WT protein
  • Wt-1 protein
  • wt1 protein
  • WT33 protein
  • XeWT1 protein
  • xwt1 protein
  • XWT1a protein
  • XWT1b protein
  • zgc:152697 protein

Protein level used designations for Wilms Tumor 1 Proteins (WT1)

Wilms tumor 1 , Wilms tumor protein homolog A , Wilms tumor protein homolog , Wilms tumor protein , amino-terminal domain of EWS , last three zinc fingers of the DNA-binding domain of WT1 , Wilm's tumor suppressor , Wilms tumor protein homolog B , Chick Wilm's tumour protein , Wilms tumor suppressor protein 1b

782183 Bos taurus
280959 Bos taurus
373588 Xenopus laevis
614584 Bos taurus
696061 Macaca mulatta
737987 Pan troglodytes
100101227 Ovis aries
100216184 Xenopus (Silurana) tropicalis
100346776 Oryctolagus cuniculus
100380493 Salmo salar
7490 Homo sapiens
378664 Xenopus laevis
396139 Gallus gallus
609253 Canis lupus familiaris
397338 Sus scrofa
24883 Rattus norvegicus
22431 Mus musculus
568416 Danio rerio
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