Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
WT1 encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. Additionally we are shipping WT1 Proteins (5) and many more products for this protein.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
miR (show MLXIP ELISA Kits)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR (show UTS2R ELISA Kits) of WT1 mRNA and miR (show MLXIP ELISA Kits)-125a knockout mice induce myeloproliferative disease (MPD (show MVD ELISA Kits)) and urogenital abnormalities
The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.
During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21 (show TCF21 ELISA Kits)-LacZ (show GLB1 ELISA Kits) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.
Wt1 is essential for normal development at all kidney developmental stages under study.
Wt1 expression levels in podocytes regulate Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling through modulating the endocytic fate of LRP6 (show LRP6 ELISA Kits), and this indicates a potential target for the therapy of CKD.
The results suggest a possible role for Wt1 in cardiac vessel formation in development and disease.
Conditional beta-catenin (show CTNNB1 ELISA Kits) loss phenocopies the Wt1 mutant diaphragm defect, while constitutive activation of beta-catenin (show CTNNB1 ELISA Kits) on the Wt1 mutant background is sufficient to close the diaphragm defect
WT1 modulates receptor tyrosine kinase (show ERBB3 ELISA Kits) signaling in nephron progenitor cell by directing the expression of Gas1 (show GAS1 ELISA Kits).
WT1 can modulate LHbeta (show LHB ELISA Kits) transcription with differential roles for the two WT1 variants
the results of this study demonstrate a novel association between fibrocyte-driven WT1(+) cell accumulation and severe fibrotic lung disease.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms.
Wilms tumor protein homolog