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Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. Additionally we are shipping Xanthine Dehydrogenase Antibodies (86) and Xanthine Dehydrogenase Kits (30) and many more products for this protein.
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Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury.
crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR]
Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.
6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase.
Hydrogen peroxide is the major oxidant product of xanthine oxidase
Phe-549, Arg-335, Trp (show TRPC5 Proteins)-336, & Arg-427 form the core of a relay system for the XDH/XO transition.They gate a solvent channel leading toward the FAD (show PSEN1 Proteins) ring.
Results describe the formation of peroxynitrite from the simultaneous reduction of nitrite and oxygen by xanthine oxidase.
Stimulation of XDH conversion to xanthine oxidase may represent a feed-forward mechanism whereby H2O2 can stimulate further production of reactive oxygen species
evidence xanthine oxidase (XO) is regulated by transmembrane secretion of xanthine &/or hypoxanthine to extracellular environment; response of XO to bacteria & bacteria-dependent nitrosative stress demonstrates it is part of mammary gland immune system
Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase: CRYSTAL STRUCTURES IN COMPLEX WITH XANTHINE AND LUMAZINE.
Results show XOR strictly modulated at the transcriptional and post-translational levels, and its expression and activity are highly variable in cancer and negatively associated with high malignity grade and a worse prognosis. [review]
XDH and SUCLA2 (show SUCLA2 Proteins) genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.
Thyroid stimulating hormone levels are increase in gout patients treated with inhibitors of xanthine oxidoreductase.
The XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension in a rural Chinese population.
the essential role of autophagy-regulated early ROS (show ROS1 Proteins) in triggering late apoptotic signaling
XOR regulated macrophage IL-1b secretion upon NLRP3 inflammasome activation via xanthine oxidase derived reactive oxygen species.
In this review, we focus on studies of XOR inhibitors and their implications for understanding the chemical nature and reaction mechanism of the Moco active site of XOR
xanthine oxidase-mediated ROS production is required for PTN-induced cell migration through the cell membrane functional complex of alphanubeta3 and RPTPbeta/zeta and activation of c-src, PI3K and ERK1/2 kinases
Data suggest that, with aging, up-regulation of reactive oxygen species derived from XO down-regulates uric acid excretion via down-regulation of active homodimer breast cancer resistance protein (BCRP1, uric acid efflux transporter) in ileal mucosa.
Xanthine oxidase is activated in THP-1 human myeloid cells in response to pro-inflammatory and growth factor stimulation.
inflammasome activation accompanied by an increase in xanthine oxidoreductase activity contributed to fat pad inflammation followed by osteoarthritis progression
XOR is abundant in wounds and participates in normal wound healing through effects on ROS (show ROS1 Proteins) production.
Xanthine oxidase inhibitors are potentially potent therapies for patients with NASH (show SAMSN1 Proteins), particularly that associated with hyperuricemia.
these data support a novel function of the XO-NFAT5 (show NFAT5 Proteins) axis in macrophage activation and TLR-induced arthritis
Reduction in XOR gene expression in mice augments lipid accumulation in adipocytes, accompanied by an increase in oxidative stress, and induces obesity with insulin (show INS Proteins) resistance in older age.
Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase.
Mouse Xdh is a moonlighting protein that has two distinct catalytic activities and acts a structural protein in milk fat droplets.
In conclusion, CS increases XOR expression, and the enzyme is both sufficient and necessary for p53 (show TP53 Proteins) induction and CS-induced EC apoptosis.
we have established a mouse model for autosomal recessive early-onset renal failure due to a nonsense mutation in Xdh that is a model for xanthinuria in man.
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
XDH xanthine dehydrogenase
, xanthine oxidase
, xanthine dehydrogenase
, Xanthine dehydrogenase/oxidase
, xanthine dehydrogenase/oxidase-like
, Xanthine dehydrogenase
, xanthine dehydrogenase/oxidase
, xanthene dehydrogenase
, xanthine oxidoreductase