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Probable transcriptional activator.
Showing 3 out of 4 products:
Mouse (Murine) Polyclonal ZFY1 Primary Antibody for WB - ABIN2779911
Jeong, Park, Lee: The analysis of X-chromosome inactivation-related gene expression from single mouse embryo with sex-determination. in Biochemical and biophysical research communications 2005
we show that in mice, Zfy (show ZFY Antibodies) genes(Zfy1 and Zfy2 (show ZFY2 Antibodies) ) are also necessary for efficient meiotic sex chrand the sex chromosomes are not correctly silenced in Zfy (show ZFY Antibodies)-deficient spermatocytes.
Zfy1-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
genetic information on the short arm of the Y chromosome promotes meiosis II, and by transgene addition Zfy1 and Zfy2 (show ZFY2 Antibodies) were identified as the genes responsible.
Studies identified a Zfy2 (show ZFY2 Antibodies) transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain.
Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).
Y-linked zinc finger protein 1
, zinc finger Y-chromosomal protein 1