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Probable transcriptional activator.
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Zfy2-KO mice did not show any significant phenotypic alterations. Zfy1 (show ZFY1 Antibodies)/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development
Zfy2 is essential for sperm formation and is essential for sperm function in assisted fertilization procedure.
Zfy2 proved to be essential for the efficient operation of a 'checkpoint' during the first meiotic division that identifies and kills cells that would otherwise produce sperm with an unbalanced chromosome set.
The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
Studies identified a Zfy2 transcript that predominates in spermatids, and a Zfy1 (show ZFY1 Antibodies) transcript, lacking an exon encoding approximately half of the acidic domain.
Zfy2 (but not the closely related Zfy1 (show ZFY1 Antibodies)) is sufficient to reinstate the apoptotic response to the X univalent meiotic cell.
Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).
Y-linked zinc finger protein 2
, zinc finger Y-chromosomal protein 2