Zinc Finger Protein 36, C3H Type, Homolog (Mouse) Proteins (ZFP36)

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Additionally we are shipping ZFP36 Antibodies (78) and ZFP36 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse ZFP36 ZFP36 67150 Q99MB7
ZFP36 7538 P26651
Rat ZFP36 ZFP36 79426 P47973
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Top ZFP36 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,871.00
Details

ZFP36 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

Top referenced ZFP36 Proteins

  1. Human ZFP36 Protein expressed in Wheat germ - ABIN1325745 : McDermott, Ellis, Bou-Gharios, Clegg, Tew: RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. in Osteoarthritis and cartilage 2016 (PubMed)

More Proteins for Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) Interaction Partners

Mouse (Murine) Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) interaction partners

  1. the gain-of-function mutation of TTP impairs IL-10 (show IL10 Proteins)-mediated negative feedback control of macrophage function in vitro.

  2. Studies indicate that mice lacking tristetraprolin (TTP) developed a spontaneous and pervasive inflammatory syndrome.

  3. The data demonstrate that cigarette smoke exposure reduces TTP expression and impairs TTP function, resulting in significantly increased TNF-alpha (show TNF Proteins) mRNA stability and excessive TNF-alpha (show TNF Proteins) expression in alveolar macrophages and epithelial cells.

  4. study uncovers a role of TTP as a suppressor of feedback inhibitors of inflammation and highlights the importance of fine-tuned TTP activity-regulation by MK2 (show KCNA2 Proteins) in order to control the pro-inflammatory response

  5. TTP is not involved in LPS (show TLR4 Proteins)-mediated destabilization of PLCbeta-2 mRNA in macrophages

  6. Zinc Finger Protein 36 (show ZKSCAN1 Proteins) deficiency has profound effects on the splenic transcriptome.

  7. Mouse LARP4 is regul (show LARP4 Proteins)ated by TNF-alpha in a TT (show TNF Proteins)P-dependent manner.

  8. Regulation of mRNAs by tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis.

  9. Tristetraprolin limits inflammatory cytokine production in tumor-associated macrophages in an mRNA decay-independent manner.

  10. Dominant suppression of inflammation can be achieved via targeted mutation of the mRNA destabilizing protein tristetraprolin.

Human Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) interaction partners

  1. Because TTP (show ADAMTS13 Proteins) also represses IL-1beta (show IL1B Proteins) expression, it is a dual inhibitor of the IL-1beta (show IL1B Proteins) system, regulating expression of the cytokine and the upstream controller NLRP3 (show NLRP3 Proteins)

  2. Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins) and TNFalpha (show TNF Proteins) mRNA degradation, destabilized TNFalpha (show TNF Proteins) mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP).

  3. TTP (show ADAMTS13 Proteins) was demonstrated to destabilize the VEGF (show VEGFA Proteins) mRNA in ARPE-19 cells under hypoxic conditions. Furthermore, CM from TTP (show ADAMTS13 Proteins)-overexpressing ARPE-19 cells suppressed tube formation in HUVECs.

  4. this study shows that TTP (show ADAMTS13 Proteins) is down-regulated in glioma tissue samples and cell lines, and is associated with diminished survival in glioma patients

  5. TTP (show ADAMTS13 Proteins) inhibited the proliferation, migration, and invasion of gastric cancer cell lines through regulation of IL-33 (show IL33 Proteins).

  6. Results suggest that ZFP36 proteins might control reepithelialization and angiogenesis in the skin in a multimodal manner.

  7. Our data offer the convincing evidence for the first time that the aberrant expressions of ZFP36 and SOCS3 (show SOCS3 Proteins) may be involved into the progression and patients' prognosis of prostate cancer

  8. Low TTP (show ADAMTS13 Proteins) expression is associated with epithelial-mesenchymal transition in cancer.

  9. PP2A (show PPP2R4 Proteins) activators boost the anti-inflammatory function of TTP (show ADAMTS13 Proteins) and have implications for future pharmacotherapeutic strategies to combat inflammation in respiratory disease.

  10. The mRNA destabilizing activity of TTP (show ADAMTS13 Proteins) was increased when the partially disordered RNA binding domain (RBD (show CACNA1D Proteins)) of TTP (show ADAMTS13 Proteins) was replaced with the fully structured RBD (show CACNA1D Proteins) of TIS11d (show ZFP36L2 Proteins), indicating that differences in the folded state of the RBD (show CACNA1D Proteins) affect the activity of the proteins in the cell.

Pig (Porcine) Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) interaction partners

  1. direct interaction between TTP protein and porcine TNF-alpha (show TNF Proteins) mRNA ARE probe

ZFP36 Protein Profile

Protein Summary

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Gene names and symbols associated with ZFP36

  • tristetraproline (EDI_287240)
  • Tristetraproline (Bm1_42085)
  • tristetraproline (LOAG_03119)
  • similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth (ZFP36)
  • zinc finger protein 36, C3H type, homolog (mouse) (ZFP36)
  • ZFP36 ring finger protein (zfp36)
  • ring finger protein 141 (Rnf141)
  • ZFP36 ring finger protein (ZFP36)
  • zinc finger protein 36 (Zfp36)
  • 2610110L04Rik protein
  • AA792898 protein
  • AU022812 protein
  • c3h-1 protein
  • G0S24 protein
  • Gos24 protein
  • Nup475 protein
  • RNF162A protein
  • Tis11 protein
  • TIS11D protein
  • TISII protein
  • Ttp protein
  • Zfp-36 protein
  • ZFP36 protein
  • ZNF230 protein

Protein level used designations for ZFP36

tristetraproline , Tristetraproline , similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth , zinc finger protein 36, C3H type, homolog (mouse) , tristetraprolin , zinc finger protein 36, C3H type, homolog , RING finger protein 141 , zinc finger protein 230 , CCCH zinc finger protein C3H-1 , G0/G1 switch regulatory protein 24 , growth factor-inducible nuclear protein NUP475 , zinc finger protein 36 homolog , zinc finger protein, C3H type, 36 homolog , TTP , zfp-36 , TPA-induced sequence 11 , CCCH (CX8CX5CX3H) zinc finger domain RNA-binding protein , TIS11 , zinc finger protein homologous to Zfp-36 in mouse , TNF alpha inhibitor , Tax interacting protein

GENE ID SPECIES
5879635 Entamoeba dispar SAW760
6103302 Brugia malayi
9940506 Loa loa
698280 Macaca mulatta
736203 Pan troglodytes
100127733 Xenopus (Silurana) tropicalis
67150 Mus musculus
398102 Xenopus laevis
7538 Homo sapiens
79426 Rattus norvegicus
22695 Mus musculus
484510 Canis lupus familiaris
100316849 Sus scrofa
282127 Bos taurus
443283 Ovis aries
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