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alpha-Fetoprotein Proteins (AFP)

AFP encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Additionally we are shipping alpha Fetoprotein Antibodies (1058) and alpha Fetoprotein Kits (87) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AFP 11576 P02772
AFP 174 P02771
AFP 24177  
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Top alpha Fetoprotein Proteins at

Showing 10 out of 58 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Human Human Un-conjugated   1 mg Log in to see 7 to 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Cell culture Human Un-conjugated   1 mg Log in to see 3 to 4 Days

AFP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , ,
Rat (Rattus) ,

Top referenced alpha Fetoprotein Proteins

  1. Human alpha Fetoprotein Protein expressed in Human - ABIN934455 : Lee, Lee: Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. in Biochemical and biophysical research communications 2012 (PubMed)

  2. Human alpha Fetoprotein Protein expressed in Cell culture - ABIN573558 : Mikhaylova, Schumacher, Borutzki, Neumann, Macharadze, El-Mousleh, Wahle, Zenclussen, Kreutz: Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide. in BMC research notes 2014 (PubMed)

  3. Human alpha Fetoprotein Protein expressed in Human Cells - ABIN2005088 : Tomasi: Structure and function of alpha-fetoprotein. in Annual review of medicine 1977 (PubMed)

More Proteins for alpha-Fetoprotein (AFP) Interaction Partners

Mouse (Murine) alpha-Fetoprotein (AFP) interaction partners

  1. endogenous AFP expression in the perinatal liver is reduced in the absence of beta-catenin (show CTNNB1 Proteins), suggesting that beta-catenin (show CTNNB1 Proteins) regulates AFP during liver development.

  2. Findings indicate that AFP expressed under experimental cryptorchid conditions plays a role as a regulatory factor in spermatogenesis and in hepatic generation.

  3. AFP mRNA and VEGF-C (show VEGFC Proteins) mRNA in peripheral blood were significantly correlated with recurrence and metastasis of hepatocellular carcinoma.

  4. A DEHP treatment-induced phenotype was identified with lack of glycogen (show GYS1 Proteins) accumula-tion and intracytoplasmic localization of beta-catenin (show CTNNB1 Proteins) which was associated with increased AFP gene expression.

  5. The deficits observed in parental behavior of AFP knockout females could not be explained by any changes in olfactory function, novelty recognition or anxiety

  6. Foxa1 (show FOXA1 Proteins) acts as a pioneer transcription factor in de novo activation of Afp, by exploiting a lack of methylation at juxtaposed transposed elements

  7. The level of AFP mRNA in peripheral blood may indicate recurrence and/or metastasis after curative resection of hepatocellular carcinoma.

  8. AFP affects cell proliferation by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras (show HRAS Proteins) p21 genes

  9. A murine Nkx2.8 (show NKX2-6 Proteins) was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor (show NR5A2 Proteins).

  10. The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (show FOXA1 Proteins)

Human alpha-Fetoprotein (AFP) interaction partners

  1. Elevated insulin (show INS Proteins) resistance, leptin (show LEP Proteins), serum iron, ferritin (show FTL Proteins), mean platelet volume, NLR (show CXCR5 Proteins), and advanced fibrosis, as well as decreased platelet count and serum albumin (show ALB Proteins), are independently associated with an elevated AFP level in chronic hepatitis C.

  2. VEGF (show VEGFA Proteins) could be a potential biomarker for HCC (show FAM126A Proteins), while AFP could be used to distinguish between patients with HCC (show FAM126A Proteins) and cirrhosis or HCV.

  3. Data indicate the diagnostic criteria of chorionic gonadotropin beta subunit (show CGB Proteins) (beta-hCG (show CGA Proteins)) and alpha-Fetoprotein (alphaFP) in CSF (show CSF2 Proteins) and serum, which may advance the early and formal diagnosis of intracranial germ cell tumors (ICGCTs).

  4. The risk of post-transplant hepatocellular carcinoma recurrence is dependent on the last pre-transplant AFP regardless of its previous dynamics.

  5. Results show that AFP normalization within three months after stereotactic body radiotherapy (SBRT) is a prognostic surrogate for overall survival and progression free survival in patients with small hepatocellular carcinoma.

  6. A high level of serum AFP is an independent prognostic factor in gastric cancer and can be used for evaluating the prognosis of gastric cancers whether in the presence or absence of liver metastasis.

  7. Simultaneous determination of the AFP, AFP-L3 and TP53 (show TP53 Proteins) yielded a better diagnostic accuracy and sensitivity in the detection of HCCs (show HCCS Proteins) than each biomarker alone.

  8. the accuracy of des (show DES Proteins)-gamma-carboxy prothrombin (show F2 Proteins) for distinguishing hepatocellular carcinoma from various controls was 6.2-9.7% higher than that of AFP

  9. Integration of the AFP delta-slope with conventional criteria may further improve HCC (show FAM126A Proteins) patient selection for liver transplantation and treatment outcomes.

  10. AFP remained the best single marker, and the combined use of AFP with prothrombin (show F2 Proteins) precursor or DKK-1 (show DKK1 Proteins) had the best diagnostic performance compared to all other possible combinations of the four biomarkers, even in early stage hepatocellular carcinoma.

Horse (Equine) alpha-Fetoprotein (AFP) interaction partners

  1. Equine alpha-fetoprotein seems to be an important indicator of fetal well-being in horses.

  2. This study confirmed that alpha-fetoprotein (AFP) is present in the fetal fluids of mares during the third trimester of pregnancy; experimentally induced placentitis was associated with an elevation in maternal plasma concentrations of AFP.

alpha Fetoprotein (AFP) Protein Profile

Protein Summary

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

Gene names and symbols associated with alpha-Fetoprotein Proteins (AFP)

  • alpha-fetoprotein (AFP)
  • alpha fetoprotein (Afp)
  • alpha-fetoprotein (Afp)
  • FETA protein
  • HPAFP protein

Protein level used designations for alpha-Fetoprotein Proteins (AFP)

alpha-1-fetoprotein , alpha-fetoglobulin , alpha-fetoprotein , alpha-foetoprotein , chloride intracellular channel 6

704786 Macaca mulatta
11576 Mus musculus
174 Homo sapiens
403551 Canis lupus familiaris
397586 Sus scrofa
24177 Rattus norvegicus
506011 Bos taurus
422652 Gallus gallus
100034185 Equus caballus
100345865 Oryctolagus cuniculus
100728693 Cavia porcellus
461258 Pan troglodytes
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