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Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression.
Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia.
Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 (show TLR2 ELISA Kits) expression.
These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance.
Significant association between the -58T/C polymorphism and the increased risk of Hypertension was found in Northern Han Chinese population.
Bradykinin inhibits oxidative stress-induced (show SQSTM1 ELISA Kits) senescence of endothelial progenitor cells through the B2R/AKT (show AKT1 ELISA Kits)/RB and B2R/EGFR (show EGFR ELISA Kits)/RB signal pathways.
Bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects bradykinin activity.
These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness.
The nasal mucosa specimens from chronic rhinosinusitis patients expressed relatively higher B2R and slightly higher kininogen (KNG (show KNG1 ELISA Kits))/BK and B1R (show BDKRB1 ELISA Kits).
BKR1 (show BDKRB1 ELISA Kits) and BKR2 gene expression on peripheral monocytes is upregulated in essential hypertension
B2R activation occurs in the diabetic skin and delays wound healing. B2R blockade improves skin wound healing in diabetic mice and is a potential therapeutic approach to diabetic ulcers.
a novel pathway by which C5aR (show C5AR1 ELISA Kits)/B2R cross-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinates antiparasite immunity.
investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 (show IL4 ELISA Kits) and IL-13 (show IL13 ELISA Kits); data show, for the first time, that IL-4 (show IL4 ELISA Kits) and IL-13 (show IL13 ELISA Kits) decrease kinin receptors in a STAT6 (show STAT6 ELISA Kits)-dependent mechanism
Data suggest that nicotine impairs mucosa-dependent Bdkrb2 (bradykinin B2 receptor) mediated trachea relaxation; nicotine also down-regulates tracheal expression of COX2/Ptgs2 (cyclooxygenase 2 (show PTGS2 ELISA Kits)) and mPGES-1 (show PTGES ELISA Kits) (microsomal prostaglandin E2 synthase-1).
Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of immobilization stress; data from CRH (corticotropin-releasing hormone (show CRH ELISA Kits)) knockout mice suggest this up-regulation requires catecholaminergic glucocorticoids.
B1R (show BDKRB1 ELISA Kits) and B2R receptors exert a critical role in the establishment of persistent hypersensitivity observed in an experimental autoimmune encephalomyelitis model
Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas (show MAS1 ELISA Kits).
Null mutations at the p66 (show POLD3 ELISA Kits) and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney in mice.
These findings suggest that activation of the bradykinin/B2R pathway contributes to development of host resistance to visceral leishmaniasis.
Data indicate that under normal sodium intake, epithelial Na(+) channel (ENaC (show SCNN1A ELISA Kits)) open probability (P(o)) was modestly elevated in bradykinin receptors B1R (show BDKRB1 ELISA Kits), B2R(-/-) mice.
A persistent B2R-beta2AR (show ADRB2 ELISA Kits) heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR (show ADRB2 ELISA Kits) enhanced beta2AR (show ADRB2 ELISA Kits)-mediated release of tPA (show PLAT ELISA Kits).
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
B2 bradykinin receptor
, BK-2 receptor
, bradykinin B2 receptor
, ornithokinin receptor
, bradykinin receptor B2
, B2 bradykinin receptor-like
, b2 bradykinin receptor-like
, bradykinin receptor, beta 2
, kinin B2