Browse our anti-ITGAL (ITGAL) Antibodies

Full name:
anti-Integrin alpha-L Antibodies (ITGAL)
On are 776 Integrin alpha-L (ITGAL) Antibodies from 29 different suppliers available. Additionally we are shipping ITGAL Kits (23) and ITGAL Proteins (11) and many more products for this protein. A total of 815 ITGAL products are currently listed.
(p180), CD11a, LFA-1, LFA-1A, LFA1A, Ly-15, Ly-21
list all antibodies Gene Name GeneID UniProt
ITGAL 16408  
ITGAL 3683 P20701

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All available anti-ITGAL Antibodies

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Top referenced anti-ITGAL Antibodies

  1. Human Monoclonal ITGAL Primary Antibody for CyTOF, FACS - ABIN268962 : Ottonello, Epstein, Dapino, Barbera, Morone, Dallegri et al.: Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b ... in Blood 1999 (PubMed)
    Show all 9 references for 268962

  2. Mouse (Murine) Monoclonal ITGAL Primary Antibody for FACS - ABIN118135 : Falanga, Butcher: Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. in European journal of immunology 1991 (PubMed)
    Show all 7 references for 118135

  3. Rat (Rattus) Monoclonal ITGAL Primary Antibody for FACS, IHC (fro) - ABIN120404 : Tamatani, Kotani, Miyasaka: Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. in European journal of immunology 1991 (PubMed)
    Show all 4 references for 120404

  4. Human Monoclonal ITGAL Primary Antibody for FACS - ABIN1105774 : Galon, Gauchat, Mazières, Spagnoli, Storkus, Lötze, Bonnefoy, Fridman, Sautès: Soluble Fcgamma receptor type III (FcgammaRIII, CD16) triggers cell activation through interaction with complement receptors. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Show all 4 references for 1105774

  5. Human Monoclonal ITGAL Primary Antibody for FACS - ABIN1105768 : Vermot-Desroches, Wijdenes, Valmu, Roy, Pigott, Nortamo, Gahmberg: A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50. in European journal of immunology 1995 (PubMed)
    Show all 3 references for 1105768

  6. Mouse (Murine) Monoclonal ITGAL Primary Antibody for Func, FACS - ABIN118136 : Trowbridge, Omary: Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. in The Journal of experimental medicine 1982 (PubMed)
    Show all 2 references for 118136

  7. Rat (Rattus) Monoclonal ITGAL Primary Antibody for Func, FACS - ABIN120407 : Tamatani, Kotani, Tanaka, Miyasaka: Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells. in European journal of immunology 1991 (PubMed)
    Show all 2 references for 120407

  8. Human Monoclonal ITGAL Primary Antibody for FACS - ABIN1105775 : Canfield, Khakoo: The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin. in Journal of immunology (Baltimore, Md. : 1950) 1999 (PubMed)
    Show all 2 references for 1105775

  9. Mouse (Murine) Monoclonal ITGAL Primary Antibody for FACS - ABIN114187 : Hogarth, Walker, McKenzie, Springer: The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule. in Proceedings of the National Academy of Sciences of the United States of America 1985 (PubMed)

  10. Human Monoclonal ITGAL Primary Antibody for FACS, IF - ABIN1105773 : Wright, Jong: Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. in The Journal of experimental medicine 1987 (PubMed)

More Antibodies against ITGAL Interaction Partners

Mouse (Murine) Integrin alpha-L (ITGAL) interaction partners

  1. Data show that the marker antigen CD11A- fraction of hematopoietic stem cells (HSCs) contains all functional HSC (show FUT1 Antibodies) activity, with the CD11A+ fraction composed of more differentiated cells that lack long-term self-renewal activity.

  2. competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells

  3. Through the use of interval-specific SNP haplotype analysis, we further refined the Civq1 locus and identified integrin alpha L (Itgal) as one of the causative genes for Civq1

  4. CD11a plays a crucial role in adipose tissue inflammation by participating in T-cell infiltration and activation.

  5. CD11a and CD11b (show ITGAM Antibodies) mediate leukocyte adhesion in both arterioles and venules as well as trapping in capillaries in the lung.

  6. LFA-1/ICAM-1 (show ICAM1 Antibodies)-dependent interactions between T cells and dendritic cells play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes.

  7. Data indicate that the dimerization of integrin alphaL and beta2 is highly dependent on gp96 (show HSP90B1 Antibodies).

  8. LFA-1-mediated firm adhesion under conditions of shear flow requires downstream integrin signaling, which is dependent on calcium/calmodulin and the actin cytoskeleton.

  9. Taken together, these findings demonstrated that CD11a expression contributes to expansion and differentiation of primary CD8 (show CD8A Antibodies) T cells but may be dispensable for secondary responses to Listeria monocytogenes infection.

  10. However, this process was pertussis toxin sensitive and dependent on the integrin LFA-1.

Human Integrin alpha-L (ITGAL) interaction partners

  1. Suggest possible role for lymphocyte CD11a in the pathogenesis immune thrombocytopenia.

  2. Data show that interleukin-18 (show IL18 Antibodies) was involved in the eosinophil-mediated death of colon carcinoma cells via upregulation of CD11a/CD18 (show ITGB2 Antibodies) and ICAM-1 (show ICAM1 Antibodies) adhesion molecules.

  3. shear-induced CD11 (show CD1D Antibodies)/CD18 (show ITGB2 Antibodies) cleavage is phenotypic of neutrophilic cells, including those derived from HL60 cells

  4. Data show that leucocyte function-associated antigen-1 (integrin alphaLbeta2), DNAX accessory molecule-1 (DNAM-1 (show CD226 Antibodies)) or tumour necrosis factor (show TNF Antibodies)-related apoptosis-inducing ligand (TRAIL) enhance osteoclast survival when co-cultured with activated NK cells.

  5. LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension.

  6. the blocking of LFA-1/ICAM-1 (show ICAM1 Antibodies) interaction resulted in a significant increase in the percentage of IL-17 (show IL17A Antibodies)(+) T cells expanded in nonclassical monocyte/T-cell cocultures

  7. Studied signaling mechanisms of Lymphocyte function-associated antigen-1 (LFA-1) using NMR analysis of the dynamics of the LFA-1 I-domain.

  8. CD11a, CD11c (show ITGAX Antibodies), and CD18 (show ITGB2 Antibodies) gene polymorphisms and susceptibility to Behcet's disease in Koreans.

  9. PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration.

  10. ITGAL is overexpressed in systemic lupus erythematosus CD4 (show CD4 Antibodies)+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease.

ITGAL Antigen Profile

Antigen Summary

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ITGAL

  • integrin alpha L (Itgal) antibody
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL) antibody
  • (p180) antibody
  • CD11a antibody
  • LFA-1 antibody
  • LFA-1A antibody
  • LFA1A antibody
  • Ly-15 antibody
  • Ly-21 antibody

Protein level used designations for ITGAL

CD11 antigen-like family member A , alpha L integrin , integrin alpha-L , leukocyte adhesion glycoprotein LFA-1 alpha chain , leukocyte function-associated molecule 1 alpha chain , lymphocyte antigen 15 , lymphocyte function associated antigen 1, alpha polypeptide , LFA-1 alpha , LFA-1A , antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide , integrin gene promoter , lymphocyte function-associated antigen 1 , integrin LFA1 , lymphocyte function-associated antigen 1, alpha polypeptide , antigen CD11A , lymphocyte function-associated antigen 1, alpha

16408 Mus musculus
3683 Homo sapiens
641296 Ovis aries
281874 Bos taurus
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