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AIM2 contributes to the maintenance of intestinal integrity via Akt (show AKT1 ELISA Kits) and protects against Salmonella mucosal infection.
study identifies the AIM2 inflammasome and cGAS/IFI16 (show IFI16 ELISA Kits)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
Study conclude that functional AIM2 is preferentially expressed in adult human CD27 (show CD27 ELISA Kits)+ B-cells, but is absent in cord blood mononuclear cells.
results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.
knockdown of AIM2 by small interfering RNA attenuated caspase-1 (show CASP1 ELISA Kits) activation. the results suggest that EBV infection of human monocytes induces caspase-1 (show CASP1 ELISA Kits)-dependent IL-1beta (show IL1B ELISA Kits) production, and that AIM2, acting as an inflammasome, is involved in this response.
These data indicate that human cytomegalovirus pUL83 interacts with human AIM2 in the cytoplasm during the early stages of virus infection. The pUL83/AIM2 interaction deregulates the activation of AIM2 inflammasome.
The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.
The extent of NLRC3 (show NLRC3 ELISA Kits) and AIM2 gene reduction was correlated with cancer progression.
Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.
A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 (show IFI16 ELISA Kits) in active inflammatory bowel disease versus controls was found.
this study shows that aim2-like receptors are dispensable for the type I interferon (show IFNA ELISA Kits) response to transfected DNA ligands, DNA virus infection, and lentivirus infection
These results show for the first time that AIM2 plays an important anti-inflammatory, yet inflammasome-independent function in cardiomyocytes
These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18 (show IL18 ELISA Kits)/IL-22BP (show IL22RA2 ELISA Kits)/IL-22 (show IL22 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) pathway
AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death.
in vitro activation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 ELISA Kits)-dependent cell death.
A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
absent in melanoma 2
, interferon-inducible protein AIM2-like
, interferon-inducible protein AIM2
, interferon-inducible protein 210
, interferon-inducible protein p210