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Absent in Melanoma 2 ELISA Kits (AIM2)
On are 14 Absent in Melanoma 2 (AIM2) ELISA Kits from 7 different suppliers available. Additionally we are shipping AIM2 Antibodies (193) and AIM2 Proteins (6) and many more products for this protein. A total of 230 AIM2 products are currently listed.
AIM2, Gm1313, Ifi210, PYHIN4
list all ELISA KIts Gene Name GeneID UniProt
AIM2 9447 O14862
AIM2 383619 Q91VJ1
Rat AIM2 AIM2 304987  

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Human Absent in Melanoma 2 (AIM2) interaction partners

  1. knockdown of AIM2 by small interfering RNA attenuated caspase-1 (show CASP1 ELISA Kits) activation. the results suggest that EBV infection of human monocytes induces caspase-1 (show CASP1 ELISA Kits)-dependent IL-1beta (show IL1B ELISA Kits) production, and that AIM2, acting as an inflammasome, is involved in this response.

  2. These data indicate that human cytomegalovirus pUL83 interacts with human AIM2 in the cytoplasm during the early stages of virus infection. The pUL83/AIM2 interaction deregulates the activation of AIM2 inflammasome.

  3. The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.

  4. The extent of NLRC3 (show NLRC3 ELISA Kits) and AIM2 gene reduction was correlated with cancer progression.

  5. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.

  6. A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 (show IFI16 ELISA Kits) in active inflammatory bowel disease versus controls was found.

  7. Lung tumor-associated plasmacytoid dendritic cells (pDCs) are responsive to the activation of AIM2 that promotes calcium efflux and reactive oxygen species from mitochondria, leading to calpain activation and high levels of IL-1alpha.

  8. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 ELISA Kits), NLRC4 (show NLRC4 ELISA Kits) and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD ELISA Kits) speck

  9. pyrin (show MEFV ELISA Kits) domain drives both filament formation and dsDNA binding

  10. activation of the AIM2 inflammasome did not require a priming signal in ascitic fluid-derived macrophages, demonstrating the preactivated state of the inflammasome in these cells.

Mouse (Murine) Absent in Melanoma 2 (AIM2) interaction partners

  1. These results show for the first time that AIM2 plays an important anti-inflammatory, yet inflammasome-independent function in cardiomyocytes

  2. These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18 (show IL18 ELISA Kits)/IL-22BP (show IL22RA2 ELISA Kits)/IL-22 (show IL22 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) pathway

  3. AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death.

  4. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.

  5. in vitro activation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 ELISA Kits)-dependent cell death.

  6. A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition.

  7. AIM2 inflammsome is functionally redundant in the inflammasomemediated caspase-1 (show CASP1 ELISA Kits) activation and IL-1beta (show IL1B ELISA Kits) production during P. aeruginosa infection.

  8. Mice lacking both AIM2 and NLRP3 (show NLRP3 ELISA Kits) fail to confine Aspergillus hyphae to inflammatory foci, leading to widespread hyphal dissemination to lung blood vessels.

  9. AIM2 reduced Akt (show AKT1 ELISA Kits) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 ELISA Kits) inhibitor reduced tumor load in Aim2(-/-) mice

  10. For the first time, this paper demonstrated that miR (show MLXIP ELISA Kits)-223 acted to inhibit IL-1beta (show IL1B ELISA Kits) production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF (show GTF2A1L ELISA Kits). Thus, it played an important role in the pathogenesis of ALF (show GTF2A1L ELISA Kits).

AIM2 Antigen Profile

Antigen Summary

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

Alternative names and synonyms associated with AIM2

  • absent in melanoma 2 (AIM2) Elisa Kit
  • absent in melanoma 2 (Aim2) Elisa Kit
  • AIM2 Elisa Kit
  • Gm1313 Elisa Kit
  • Ifi210 Elisa Kit
  • PYHIN4 Elisa Kit

Protein level used designations for Absent in Melanoma 2 (AIM2) ELISA Kits

absent in melanoma 2 , interferon-inducible protein AIM2-like , interferon-inducible protein AIM2 , ifi-210 , interferon-inducible protein 210 , interferon-inducible protein p210

457425 Pan troglodytes
100459446 Pongo abelii
719260 Macaca mulatta
9447 Homo sapiens
383619 Mus musculus
304987 Rattus norvegicus
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