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Browse our Cathepsin K Proteins (CTSK)

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Cathepsin K Proteins (CTSK)
On are 52 Cathepsin K (CTSK) Proteins from 8 different suppliers available. Additionally we are shipping Cathepsin K Antibodies (177) and Cathepsin K Kits (69) and many more products for this protein. A total of 312 Cathepsin K products are currently listed.
26/29kD-proteinase, AI323530, anon-SAGE:Wang-123, catK, CG8947, CTS02, CTSK, CTSO, CTSO1, CTSO2, Dmel\\CG8947, l(3)s3635, MMS10-Q, Ms10q, OC-2, PKND, PYCD, wu:fa95f03, wu:fb08b05, zgc:110367
list all proteins Gene Name GeneID UniProt
CTSK 1513 P43235
CTSK 13038 P55097
CTSK 29175 O35186

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Cathepsin K Proteins (CTSK) by Origin

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Horse (Equine) Cathepsin K (CTSK) interaction partners

  1. CatK inhibition in horses did affect bone marrow nucleated cells other than mature osteoclasts rendering them hypo-responsive to both TLR4 (show TLR4 Proteins)- and TLR9 (show TLR9 Proteins)-induced inflammation, predicting a proteolytic activity for CatK within the MyD88 (show MYD88 Proteins) pathway and/or the following proteolytic events required for the cytokines secretion.

Zebrafish Cathepsin K (CTSK) interaction partners

  1. components of the large latent TGFss complex were identified as novel targets of cathepsin K at neutral pH.

Human Cathepsin K (CTSK) interaction partners

  1. Cathepsin K and osteocalcin (show BGLAP Proteins) plasma levels may be suggested as the significant markers of osteopoenia/osteoporosis. In addition, cathepsin K plasma level can be also a valuable marker of severe Coronary Atherosclerosis and Coronary Artery Calcification .

  2. Six mutations in CTSK were identified in 33 families with pycnodysostosis. The high frequency of pycnodysostosis in Ceara State is the consequence of the high inbreeding in that region.

  3. The above studies not only demonstrated that CTSK was widely expressed in tooth-related cells (including odonto- clasts, periodontal ligament cells, pulp cells and odonto- blasts), but also indicated that CTSK was closely related to the development of tissues in oral and maxillofacial region as well as occurrence and development of many oral diseases.

  4. This mutation (c.480_481insT), (p.L160fsX173) is a novel frameshift mutation. The index case extends the phenotypic spectrum and the list of previously reported mutations in the CTSK gene.

  5. There is an increase in levels of CATK in type 1 Gaucher patients compared to the control group. In the patient group, CATK showed higher levels in patients with bone damage compared to those without it.

  6. elevated levels of CatK are closely associated with the presence of chronic heart failure and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of chronic heart failure

  7. Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.

  8. Matrix-metalloproteinase-9 (show MMP9 Proteins) is cleaved and activated by cathepsin K.

  9. Sequence analysis of the patient's CTSK gene revealed homozygosity for a missense mutation (c.746T>C) in exon 6, which leads to amino change (p.Ile249Thr) in the mature CTSK protein

  10. The presence of high levels of inactive proforms of cathepsin K in GBM tissues and cells indicate that in GBM the proteolytic/collagenolytic role is not its primary function but it plays rather a different yet unknown role.

Pig (Porcine) Cathepsin K (CTSK) interaction partners

  1. The CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.

Rabbit Cathepsin K (CTSK) interaction partners

  1. The authors showed CTSK upregulation in human lung specimens and elevated serum CTSK levels of patients with tuberculosis, compared with controls.

  2. Down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerated cartilage degeneration.

Mouse (Murine) Cathepsin K (CTSK) interaction partners

  1. The effects of muscarinic receptor (show CHRM5 Proteins) M3 knockout on cathepsin K expression, bone density and biomechanical properties of bone are reported.

  2. Cathepsin K expression is increased in the bone of a diabetic mouse model.

  3. Data suggest Ctsk gene, key gene upregulated during osteoclast differentiation, is transcriptionally activated during cell hypoxia-induced mitochondrial dysfunction/disruption; hnRNPA2 (heterogeneous ribonucleoprotein A2) is coactivator in this process.

  4. cathepsin K knockout attenuates age-related decline in cardiac function via suppressing caspase (show CASP3 Proteins)-dependent and caspase (show CASP3 Proteins)-independent apoptosis

  5. Data (including data from studies in knockout/transgenic mice) suggest that Ctsk is involved in inflammatory response and bone resorption in both rheumatoid arthritis and periodontitis; thus, Ctsk appears to play a role in osteoimmune responses.

  6. In a mouse model of post-traumatic osteoarthritis, cathepsin K activity was significantly increased in injured knees relative to uninjured knees.

  7. Gene deletion of cathepsin K in mice accelerated callus size resolution, significantly increased callus mineralized mass, and improved mechanical strength as compared to wild type mice.

  8. synergism between HIV proteins and pro-atherogenic shear stress to increase endothelial cell expression of the powerful protease cathepsin K

  9. in addition to its other effects, the absence of CatK in OCP limits their ability to engraft in a repairing fracture callus compared to WT OCP.

  10. Cardiac mammalian target of rapamycin (show FRAP1 Proteins) and extracellular signal-regulated kinases (ERK (show EPHB2 Proteins)) signaling cascades were upregulated by pressure overload, the effects of which were attenuated by cathepsin K knockout.

Cathepsin K (CTSK) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Alternative names and synonyms associated with Cathepsin K (CTSK)

  • cathepsin K-like (LOC100054991)
  • 26-29kD-proteinase (26-29-p)
  • cathepsin K (CTSK)
  • cathepsin K (ctsk)
  • Cathepsin K (catk)
  • cathepsin O (CTSO)
  • cathepsin K (catk)
  • cathepsin K (Ctsk)
  • 26/29kD-proteinase protein
  • AI323530 protein
  • anon-SAGE:Wang-123 protein
  • catK protein
  • CG8947 protein
  • CTS02 protein
  • CTSK protein
  • CTSO protein
  • CTSO1 protein
  • CTSO2 protein
  • Dmel\\CG8947 protein
  • l(3)s3635 protein
  • MMS10-Q protein
  • Ms10q protein
  • OC-2 protein
  • PKND protein
  • PYCD protein
  • wu:fa95f03 protein
  • wu:fb08b05 protein
  • zgc:110367 protein

Protein level used designations for Cathepsin K Proteins (CTSK)

26,29kDa proteinase , 26-29 kD-proteinase , 26-29-p-PA , 26-29kDa proteinase , 26-29kd prot , CG8947-PA , anon-SAGE:Wang-123 , cathepsin K , etID33526.16 , Cathepsin K , cathepsin O , cathepsin O1 , cathepsin O2 , cathepsin X , JTAP-1 , protein OC-2 , Cat K , minisatellite 10q detected by probe MMS10 , cathepsin K (pycnodysostosis) , cathepsin K preproprotein

100054991 Equus caballus
39547 Drosophila melanogaster
457278 Pan troglodytes
550475 Danio rerio
779889 Xenopus (Silurana) tropicalis
100127265 Xenopus laevis
100195370 Salmo salar
461567 Pan troglodytes
482665 Canis lupus familiaris
616804 Bos taurus
699868 Macaca mulatta
100528180 Ictalurus punctatus
1513 Homo sapiens
395818 Gallus gallus
397569 Sus scrofa
100009334 Oryctolagus cuniculus
13038 Mus musculus
29175 Rattus norvegicus
608843 Canis lupus familiaris
513038 Bos taurus
100718267 Cavia porcellus
101108972 Ovis aries
574112 Macaca mulatta
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