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Browse our anti-DDX58 (DDX58) Antibodies

Full name:
anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Antibodies (DDX58)
On are 181 DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antibodies from 26 different suppliers available. Additionally we are shipping DDX58 Proteins (12) and DDX58 Kits (8) and many more products for this protein. A total of 207 DDX58 products are currently listed.
6430573D20Rik, C330021E21, RHIV-1, RIG-1, RIG-I, RIGI, RLR-1
list all antibodies Gene Name GeneID UniProt
DDX58 23586 O95786
DDX58 230073 Q6Q899
DDX58 297989  

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Most Popular Reactivities for anti-DDX58 (DDX58) Antibodies

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anti-Human DDX58 Antibodies:

anti-Mouse (Murine) DDX58 Antibodies:

anti-Rat (Rattus) DDX58 Antibodies:

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Top referenced anti-DDX58 Antibodies

  1. Human Polyclonal DDX58 Primary Antibody for WB - ABIN388602 : Bao, Liu, Shan, Li, Garofalo, Casola: Human metapneumovirus glycoprotein G inhibits innate immune responses. in PLoS pathogens 2008 (PubMed)
    Show all 9 references for ABIN388602

  2. Human Polyclonal DDX58 Primary Antibody for EIA, WB - ABIN357193 : Li, Chen, Kato, Gale, Lemon: Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN357193

  3. Human Polyclonal DDX58 Primary Antibody for EIA, WB - ABIN357195 : Breiman, Grandvaux, Lin, Ottone, Akira, Yoneyama, Fujita, Hiscott, Meurs: Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. in Journal of virology 2005 (PubMed)
    Show all 5 references for ABIN357195

  4. Human Monoclonal DDX58 Primary Antibody for IP, IHC - ABIN1169336 : Gack, Nistal-Villán, Inn, García-Sastre, Jung: Phosphorylation-mediated negative regulation of RIG-I antiviral activity. in Journal of virology 2010 (PubMed)
    Show all 4 references for ABIN1169336

  5. Human Polyclonal DDX58 Primary Antibody for ELISA, IHC - ABIN4350536 : Zhu, Duan, Wang, Cao, Liu: TREM-1 activation modulates dsRNA induced antiviral immunity with specific enhancement of MAPK signaling and the RLRs and TLRs on macrophages. in Experimental cell research 2016 (PubMed)

  6. Human Polyclonal DDX58 Primary Antibody for IHC (p), WB - ABIN4350540 : Seki, Yoshizumi, Tanaka, Ryo, Ishioka, Tsukagoshi, Kozawa, Okayama, Okabe-Kado, Goya, Kimura: Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts. in Cell biology international 2014 (PubMed)

  7. Human Polyclonal DDX58 Primary Antibody for EIA, IHC (p) - ABIN500606 : Akira, Uematsu, Takeuchi: Pathogen recognition and innate immunity. in Cell 2006 (PubMed)

  8. Human Monoclonal DDX58 Primary Antibody for IHC, IHC (p) - ABIN4350538 : Pei, Deng, Ye, Wang, Gou, Liu, Zhao, Liao, Yi, Chen: Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. in Autophagy 2016 (PubMed)

  9. Human Polyclonal DDX58 Primary Antibody for WB - ABIN2775222 : Miyazaki, Kanto, Inoue, Itose, Miyatake, Sakakibara, Yakushijin, Kakita, Hiramatsu, Takehara, Kasahara, Hayashi: Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I. in Journal of medical virology 2008 (PubMed)

More Antibodies against DDX58 Interaction Partners

Human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Modulates RIG-I-dependent antiviral response is through post-translational modifications of or protein-protein interactions with RIG-I. [review]

  2. Study demonstrates how the coordinated interplay of RIG-I, TRIM25 (show TRIM25 Antibodies), and FAT10 (show UBD Antibodies) regulate the antiviral innate inflammatory response.

  3. Pyruvate carboxylase (show PC Antibodies) activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS (show MAVS Antibodies) signalosome.

  4. This study shows that RIG-I activation results in MKP-1 (show DUSP1 Antibodies)-mediated inhibition of cell proliferation in melanoma cells via controlling the p38 (show CRK Antibodies)-HSP27 (show HSPB1 Antibodies), c-Jun (show JUN Antibodies) and rpS6 (show RPS6 Antibodies) pathways

  5. HepaRG cells express a similar pattern of functional TLR/RLR (show DHX58 Antibodies) as compared to PHH, thus qualifying HepaRG cells as a surrogate model to study pathogen interactions within a hepatocyte innate system.

  6. COPD (show ARCN1 Antibodies) patients had higher interleukin (IL)-1 (show IL1A Antibodies) and IL-8 (show IL8 Antibodies) mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 (show IFIH1 Antibodies) levels. However, there was no difference in the expression of RIG-I between COPD (show ARCN1 Antibodies) patients and control subjects.

  7. In cell culture, Marburg virus infection results in a greater upregulation of IFN responses as compared to Ebolavirus infection, which correlates with differences in the efficiencies by which EBOV and MARV VP35s antagonize RIG-I signaling.

  8. These findings collectively support the conclusion that IKK (show CHUK Antibodies) modulates innate immune signaling cascades via phosphorylating the RIG-I cytosolic sensor, providing a feedback regulatory mechanism.

  9. ATP hydrolysis displaces wild-type RIG-I from this self-RNA but not from 5' triphosphate dsRNA.

  10. that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the RIG-I in a p53 and NFkappaB dependent manner

Mouse (Murine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation

  2. identifies DDX58 and MTHFSD as two TDP-43 (show TARDBP Antibodies) targets that are misregulated in amyotrophic lateral sclerosis. 1

  3. Data show that preconditioning with poly(I:C) alters toll (show TLR4 Antibodies)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.

  4. Cytosolic LMW FGF2 (show FGF2 Antibodies) functions as a negative regulator in RIG-I-mediated antiviral signaling.

  5. results indicate that Lyn (show LYN Antibodies) plays a positive regulatory role in RIG-I-mediated interferon (show IFNA Antibodies) expression as a downstream component of IPS-1 (show ISYNA1 Antibodies)

  6. In lung epithelial cells, retinoic acid-inducible gene-1 (show RARRES3 Antibodies) (RIG-I) was identified as the major RIG-I-like receptor required for RSV-induced protease expression via MAVS (show MAVS Antibodies).

  7. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response

  8. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity.

  9. senses hepatitis B virus RNA, and counteracts HBV polymerase

  10. RIG-I-like receptor (RLR (show DHX58 Antibodies)) signaling pathway was significantly affected by Yersinia pestis infection

Pig (Porcine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.

  2. These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (show IFIH1 Antibodies) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.

  3. DDX58 had two nonsynonymous SNPs in the helicase (show DNA2 Antibodies) domain.

DDX58 Antigen Profile

Antigen Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

Alternative names and synonyms associated with DDX58

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58) antibody
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58) antibody
  • 6430573D20Rik antibody
  • C330021E21 antibody
  • RHIV-1 antibody
  • RIG-1 antibody
  • RIG-I antibody
  • RIGI antibody
  • RLR-1 antibody

Protein level used designations for DDX58

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I , probable ATP-dependent RNA helicase DDX58 , putative ATP-dependent RNA helicase DDX58 , retinoic acid-inducible protein I , DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 , probable ATP-dependent RNA helicase DDX58-like , DEAD box protein 58 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-1 , RIG-I-like receptor 1 , RNA helicase RIG-I , retinoic acid inducible gene I , retinoic acid-inducible gene 1 protein , retinoic acid-inducible gene I protein , DEAD-box protein 58 , DEAD/H box polypeptide RIG-I , retinoic acid-inducible gene-I , RNA helicase induced by virus

465035 Pan troglodytes
704638 Macaca mulatta
100067920 Equus caballus
100347707 Oryctolagus cuniculus
100408692 Callithrix jacchus
100443290 Pongo abelii
23586 Homo sapiens
230073 Mus musculus
297989 Rattus norvegicus
100686785 Canis lupus familiaris
396723 Sus scrofa
504760 Bos taurus
101107257 Ovis aries
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