Browse our DDX58 Proteins (DDX58)

Full name:
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Proteins (DDX58)
On are 12 DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Proteins from 6 different suppliers available. Additionally we are shipping DDX58 Antibodies (177) and DDX58 Kits (9) and many more products for this protein. A total of 204 DDX58 products are currently listed.
6430573D20Rik, C330021E21, RHIV-1, RIG-1, RIG-I, RIGI, RLR-1
list all proteins Gene Name GeneID UniProt
DDX58 23586 O95786
DDX58 230073 Q6Q899
Rat DDX58 DDX58 297989  

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DDX58 Proteins (DDX58) by Origin

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Top referenced DDX58 Proteins

  1. Human DDX58 Protein expressed in HEK-293 Cells - ABIN2719304 : Zhao, Tian, Edeh, Brasier: Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry. in Molecular & cellular proteomics : MCP 2013 (PubMed)

More Proteins for DDX58 Interaction Partners

Human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Results identified a negative-feedback mechanism that targets RIG-I activity mediated by DAPK1 (show DAPK1 Proteins). RIG-I-mediated antiviral signaling activates DAPK1 (show DAPK1 Proteins) kinase activity and DAPK1 (show DAPK1 Proteins) inactivates RIG-I RNA sensing by direct phosphorylation of RIG-I.

  2. Mechanistically, West Nile virus NS1 (show PTPN11 Proteins) targets RIG-I and melanoma differentiation-associated gene 5 (MDA5 (show IFIH1 Proteins)) by interacting with them and subsequently causing their degradation by the proteasome.

  3. RIG-I stimulates the cellular innate immunity against hepatitis E virus infections.

  4. dynamic sumoylation and desumoylation of MDA5 (show IFIH1 Proteins) and RIG-I modulate efficient innate immunity to RNA virus and its timely termination.

  5. Taken together, the present study reveals that T80 phosphorylation of influenza A virus NS1 reduced virus replication through controlling RIG-I-mediated interferon production and viral ribonucleoprotein activity.

  6. results suggest that RNAs containing modified nucleotides interrupt signaling at early steps of the RIG-I-like innate immune activation pathway

  7. The authors found that in Sendai virus C protein (show HNRNPC Proteins) deletion mutant-infected cells, Sendai virus defective interfering RNA also functioned as an exclusive RIG-I ligand.

  8. ArfGAP domain-containing protein 2 (ADAP2 (show ADAP2 Proteins)) is identified as a key novel scaffolding protein that integrates different modules of the RIG-I pathway, located at distinct subcellular locations, and mediates cellular antiviral type I interferon (show IFNA Proteins) production.

  9. the bending structure of the panhandle RNA negates the requirement of a 5'-PPP moiety for RIG-I activation.

  10. RIG-I-like receptor-induced IRF3 (show IRF3 Proteins) mediated pathway of apoptosis (RIPA): a new antiviral pathway

Mouse (Murine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Data suggest that activation of either RIG-I/MAVS (show MAVS Proteins) or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (show GUSB Proteins) epithelial barrier integrity and reduced GVHD severity.

  2. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation

  3. identifies DDX58 and MTHFSD as two TDP-43 (show TARDBP Proteins) targets that are misregulated in amyotrophic lateral sclerosis. 1

  4. Data show that preconditioning with poly(I:C) alters toll (show TLR4 Proteins)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.

  5. Cytosolic LMW FGF2 (show FGF2 Proteins) functions as a negative regulator in RIG-I-mediated antiviral signaling.

  6. results indicate that Lyn (show LYN Proteins) plays a positive regulatory role in RIG-I-mediated interferon (show IFNA Proteins) expression as a downstream component of IPS-1 (show ISYNA1 Proteins)

  7. In lung epithelial cells, retinoic acid-inducible gene-1 (show RARRES3 Proteins) (RIG-I) was identified as the major RIG-I-like receptor required for RSV-induced protease expression via MAVS (show MAVS Proteins).

  8. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response

  9. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity.

  10. senses hepatitis B virus RNA, and counteracts HBV polymerase

Pig (Porcine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.

  2. These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (show IFIH1 Proteins) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.

  3. DDX58 had two nonsynonymous SNPs in the helicase domain.

DDX58 Protein Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

Alternative names and synonyms associated with DDX58

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58)
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58)
  • 6430573D20Rik protein
  • C330021E21 protein
  • RHIV-1 protein
  • RIG-1 protein
  • RIG-I protein
  • RIGI protein
  • RLR-1 protein

Protein level used designations for DDX58

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I , probable ATP-dependent RNA helicase DDX58 , putative ATP-dependent RNA helicase DDX58 , retinoic acid-inducible protein I , DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 , probable ATP-dependent RNA helicase DDX58-like , DEAD box protein 58 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-1 , RIG-I-like receptor 1 , RNA helicase RIG-I , retinoic acid inducible gene I , retinoic acid-inducible gene 1 protein , retinoic acid-inducible gene I protein , DEAD-box protein 58 , DEAD/H box polypeptide RIG-I , retinoic acid-inducible gene-I , RNA helicase induced by virus

465035 Pan troglodytes
704638 Macaca mulatta
100067920 Equus caballus
100347707 Oryctolagus cuniculus
100408692 Callithrix jacchus
100443290 Pongo abelii
23586 Homo sapiens
230073 Mus musculus
297989 Rattus norvegicus
100686785 Canis lupus familiaris
396723 Sus scrofa
504760 Bos taurus
101107257 Ovis aries
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