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Browse our DDX58 Proteins (DDX58)

Full name:
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Proteins (DDX58)
On are 12 DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Proteins from 6 different suppliers available. Additionally we are shipping DDX58 Antibodies (181) and DDX58 Kits (8) and many more products for this protein. A total of 207 DDX58 products are currently listed.
6430573D20Rik, C330021E21, RHIV-1, RIG-1, RIG-I, RIGI, RLR-1
list all proteins Gene Name GeneID UniProt
DDX58 23586 O95786
DDX58 230073 Q6Q899
Rat DDX58 DDX58 297989  

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DDX58 Proteins (DDX58) by Origin

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Top referenced DDX58 Proteins

  1. Human DDX58 Protein expressed in Human - ABIN2719304 : Zhao, Tian, Edeh, Brasier: Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry. in Molecular & cellular proteomics : MCP 2013 (PubMed)

More Proteins for DDX58 Interaction Partners

Human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. These results suggest that inhibition of RIG-I-mediated type I interferon (show IFNA Proteins) responses by Enterovirus 71 may contribute to the pathogenesis of viral infection.

  2. Modulates RIG-I-dependent antiviral response is through post-translational modifications of or protein-protein interactions with RIG-I. [review]

  3. Study demonstrates how the coordinated interplay of RIG-I, TRIM25 (show TRIM25 Proteins), and FAT10 (show UBD Proteins) regulate the antiviral innate inflammatory response.

  4. Pyruvate carboxylase (show PC Proteins) activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS (show MAVS Proteins) signalosome.

  5. This study shows that RIG-I activation results in MKP-1 (show DUSP1 Proteins)-mediated inhibition of cell proliferation in melanoma cells via controlling the p38 (show CRK Proteins)-HSP27 (show HSPB1 Proteins), c-Jun (show JUN Proteins) and rpS6 (show RPS6 Proteins) pathways

  6. HepaRG cells express a similar pattern of functional TLR/RLR (show DHX58 Proteins) as compared to PHH, thus qualifying HepaRG cells as a surrogate model to study pathogen interactions within a hepatocyte innate system.

  7. COPD (show ARCN1 Proteins) patients had higher interleukin (IL)-1 (show IL1A Proteins) and IL-8 (show IL8 Proteins) mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 (show IFIH1 Proteins) levels. However, there was no difference in the expression of RIG-I between COPD (show ARCN1 Proteins) patients and control subjects.

  8. In cell culture, Marburg virus infection results in a greater upregulation of IFN responses as compared to Ebolavirus infection, which correlates with differences in the efficiencies by which EBOV and MARV VP35s antagonize RIG-I signaling.

  9. These findings collectively support the conclusion that IKK (show CHUK Proteins) modulates innate immune signaling cascades via phosphorylating the RIG-I cytosolic sensor, providing a feedback regulatory mechanism.

  10. ATP hydrolysis displaces wild-type RIG-I from this self-RNA but not from 5' triphosphate dsRNA.

Mouse (Murine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation

  2. identifies DDX58 and MTHFSD as two TDP-43 (show TARDBP Proteins) targets that are misregulated in amyotrophic lateral sclerosis. 1

  3. Data show that preconditioning with poly(I:C) alters toll (show TLR4 Proteins)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.

  4. Cytosolic LMW FGF2 (show FGF2 Proteins) functions as a negative regulator in RIG-I-mediated antiviral signaling.

  5. results indicate that Lyn (show LYN Proteins) plays a positive regulatory role in RIG-I-mediated interferon (show IFNA Proteins) expression as a downstream component of IPS-1 (show ISYNA1 Proteins)

  6. In lung epithelial cells, retinoic acid-inducible gene-1 (show RARRES3 Proteins) (RIG-I) was identified as the major RIG-I-like receptor required for RSV-induced protease expression via MAVS (show MAVS Proteins).

  7. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response

  8. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity.

  9. senses hepatitis B virus RNA, and counteracts HBV polymerase

  10. RIG-I-like receptor (RLR (show DHX58 Proteins)) signaling pathway was significantly affected by Yersinia pestis infection

Pig (Porcine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.

  2. These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (show IFIH1 Proteins) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.

  3. DDX58 had two nonsynonymous SNPs in the helicase domain.

DDX58 Protein Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

Alternative names and synonyms associated with DDX58

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58)
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58)
  • 6430573D20Rik protein
  • C330021E21 protein
  • RHIV-1 protein
  • RIG-1 protein
  • RIG-I protein
  • RIGI protein
  • RLR-1 protein

Protein level used designations for DDX58

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I , probable ATP-dependent RNA helicase DDX58 , putative ATP-dependent RNA helicase DDX58 , retinoic acid-inducible protein I , DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 , probable ATP-dependent RNA helicase DDX58-like , DEAD box protein 58 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-1 , RIG-I-like receptor 1 , RNA helicase RIG-I , retinoic acid inducible gene I , retinoic acid-inducible gene 1 protein , retinoic acid-inducible gene I protein , DEAD-box protein 58 , DEAD/H box polypeptide RIG-I , retinoic acid-inducible gene-I , RNA helicase induced by virus

465035 Pan troglodytes
704638 Macaca mulatta
100067920 Equus caballus
100347707 Oryctolagus cuniculus
100408692 Callithrix jacchus
100443290 Pongo abelii
23586 Homo sapiens
230073 Mus musculus
297989 Rattus norvegicus
100686785 Canis lupus familiaris
396723 Sus scrofa
504760 Bos taurus
101107257 Ovis aries
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