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Mouse (Murine) Polyclonal Tlr12 Primary Antibody for FACS - ABIN4359919
Palladino, Johnson, Gupta, Chapman, Ojha: Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. in Biology of reproduction 2007
Show all 2 references for ABIN4359919
Mouse (Murine) Polyclonal Tlr12 Primary Antibody for FACS, WB - ABIN4359921
Palladino, Savarese, Chapman, Dughi, Plaska: Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa. in American journal of reproductive immunology (New York, N.Y. : 1989) 2008
Show all 2 references for ABIN4359921
Human Polyclonal Tlr12 Primary Antibody for DB, ELISA - ABIN4359918
Roach, Glusman, Rowen, Kaur, Purcell, Smith, Hood, Aderem: The evolution of vertebrate Toll-like receptors. in Proceedings of the National Academy of Sciences of the United States of America 2005
Biochemical experiments revealed that TLR11 (show Tlr11 Antibodies) and TLR12 directly bind to Toxoplasma gondii profilin (show PFN1 Antibodies) and are capable of forming a heterodimer complex.
While parasite RNA and DNA activate innate immune responses via TLR7 (show TLR7 Antibodies) and TLR9 (show TLR9 Antibodies), TLR11 (show Tlr11 Antibodies) and TLR12 heterodimers are required for sensing and responding to Toxoplasma profilin (show PFN1 Antibodies) infection.
Recognition of profilin (show PFN1 Antibodies) by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system.