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Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
These studies define a novel role for ABIN1 dysfunction and NF-kappaB (show NFKB1 Proteins) in mediating glomerulonephritis through proinflammatory activation of podocytes.
IM could upregulate A20 (show TNFAIP3 Proteins) protein to inhibit the activation of NF-kappaB (show NFKB1 Proteins) pathway in Jurkat T cells, which was independent of the ABIN1 protein.
LILRB1 (show LILRB1 Proteins) ligation during monocyte differentiation to dendritic cells in vitro increases ABIN1 expression. Increased ABIN1 expression occurs in "immunosuppressive" monocytes of patients with non-Hodgkin lymphoma ex vivo. ABIN1 siRNA allows dendritic cells and immunosuppressive monocytes to respond to stimulation by allowing NF-kappaB (show NFKB1 Proteins) translocation to the nucleus, more phagocytosis, cytokine secretion, and T-cell stimulation.
These findings show ABIN1 as an intrinsic suppressor of HIV-1 mRNA transcription by regulating the ubiquitination of Tat (show TAT Proteins).
Polymorphisms in TNIP1 are associated with GPP in Chinese Han population. However, no association with PPP was found. These findings suggest that TNIP1 might be a susceptibility gene for GPP.
The findings of this study suggested that TNIP1 is a new potential predisposing gene to spina bifida (SB) and its pathway needs to be investigated in human NTD in order to confirm its role and to plan appropriate counseling to families
Data suggest that reduced TNFalpha (show TNF Proteins)-induced protein 3 (show HSPB3 Proteins)-interacting protein 1 (TNIP1) expression may have a role in the pathogenesis of myasthenia gravis (MG)for patients with thymoma.
HIV-1 depends on host-cell-encoded factors to complete its life cycle; data suggest that nucleus-located NAF1/TNIP1 promotes nuclear export of un-spliced HIV-1 gag mRNA; association between NAF1/TNIP1 and CRM1 (show XPO1 Proteins) is required for this function.
Hepatitis C virus antigen stimulation up-regulates A20/A20 (show TNFAIP3 Proteins)-binding inhibitor of NF-kappaB (show NFKB1 Proteins) binding protein expression, which consequently contributes to inefficient M1 macrophage polarization.
Data suggest that tumour necrosis factor alpha (show TNF Proteins)-induced protein 3 (show HSPB3 Proteins) (TNFAIP3 (show TNFAIP3 Proteins)) and TNFAIP3-interacting protein 1 (TNIP1) single nucleotide polymorphisms (SNPs) confer increased risk of psoriasis in ethnic South Indian Tamils.
Suppression of IRAK1 (show IRAK1 Proteins) or IRAK4 (show IRAK4 Proteins) Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1
These results suggest that the ABIN1-mediated hyperactivation of IKKs and MAPKs might mediate chronic inflammation and CVD development.
studies link ABIN-1 with IL-23 (show IL23A Proteins) and IL-17 (show IL17A Proteins), and they provide cellular and molecular mechanisms by which ABIN-1 regulates susceptibility to psoriasis.
data reveal ABIN1 as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPbeta (show CEBPB Proteins) activity
ABIN1 requires its ubiquitin binding domain and cooperates with TAX1BP1 (show TAX1BP1 Proteins) and A20 (show TNFAIP3 Proteins) to restrict antiviral signaling.
the interaction of ABIN1 with polyubiquitin (show UBB Proteins) is required to limit the activation of TLR-MyD88 (show MYD88 Proteins) pathways and prevent autoimmunity
Using a murine model of allergen-induced asthma, we have demonstrated that adenovirus-mediated delivery of ABIN-1 to the lung epithelium results in a reduction of allergen-induced eosinophil infiltration into the lungs.
ABIN-1 inhibits caspase 8 (show CASP8 Proteins) recruitment to FADD (show FADD Proteins) (Fas (show FAS Proteins)-associated death domain-containing protein) in TNF (show TNF Proteins)-induced signalling complexes, preventing caspase 8 (show CASP8 Proteins) cleavage and programmed cell death.
we cloned the pig ABIN-1 gene to investigate its potential effects on pig reproduction traits.
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.
, Nef-associated factor 1
, TNFAIP3-interacting protein 1
, TNFAIP3 interacting protein 1
, TNFAIP3-interacting protein 1-like
, A20-binding inhibitor of NF-kappa-B activation 1
, HIV-1 Nef-interacting protein
, Nef-associated factor 1 SNP
, virion-associated nuclear shuttling protein
, A20-binding inhibitor of NF-kappa B activation
, A20 binding and inhibitor of NF-kB protein 1
, c-ets-1 oncogene
, p54 transcription factor
, protein C-ets-1
, transforming protein p54/c-ets-1
, transforming protein p68/c-ets-1
, virion-associated nuclear-shuttling protein