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We suggest from those results that Mo25 and Fray operate together or in the same pathway in Drosophila asymmetric processes, and that their function counterbalances Lkb1 (show STK11 ELISA Kits).
Structural comparison indicates that the overall structures of zebrafish and human MO25 are very similar, suggesting that MO25 has conserved functions in the zebrafish.
miR (show MLXIP ELISA Kits)-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion
These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 (show STK24 ELISA Kits) family protein kinases.
Authors conclude that miR (show MLXIP ELISA Kits)-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathway indirectly.
MO25 is a master regulator of SPAK (show STK39 ELISA Kits)/OSR1 (show OXSR1 ELISA Kits) and MST3 (show STK24 ELISA Kits)/MST4/YSK1 (show STK25 ELISA Kits) protein kinases.
study describes structure of the core heterotrimeric LKB1 (show STK11 ELISA Kits)-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 (show STK11 ELISA Kits) activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 (show STK11 ELISA Kits) function
STRADalpha.MO25alpha complexes containing LKB1 (show STK11 ELISA Kits) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 ELISA Kits), BRSK1 (show BRSK1 ELISA Kits), and BRSK2 (show BRSK2 ELISA Kits)
These data define a brush border induction pathway downstream of the Lkb1 (show STK11 ELISA Kits)/Strad (show STRADA ELISA Kits)/Mo25 polarization complex, yet separate from other polarity events.
ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 (show STK11 ELISA Kits) activation.
Cab39 differentially interacts with WNK4 (show WNK4 ELISA Kits) and SPAK (show STK39 ELISA Kits)/OSR1 (show OSR1 ELISA Kits) to switch the classic two kinase cascade into a signal kinase transduction
Elevated miR (show MLXIP ELISA Kits)-195 targets the LKB1 (show STK11 ELISA Kits)/AMPK (show PRKAA1 ELISA Kits) signaling axis in hypertrophic cardiomyopathy
Quantitative PCR revealed significantly reduced LKB1 (show STK11 ELISA Kits), MO25alpha, and STRADbeta mRNA in LKB1 (show STK11 ELISA Kits)(-/-) muscle. These findings demonstrate that the LKB1 (show STK11 ELISA Kits)-MO25-STRAD (show STRADA ELISA Kits) complex is the principal AMPKK in skeletal muscle.
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).
, calcium-binding protein 39
, calcium binding protein 39
, calcium binding protein 39-like
, calcium-binding protein 39-like
, Cab39 protein
, calcium binding protein, 39 kDa