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Human CPT1B ELISA Kit for Sandwich ELISA - ABIN420987
Lehmann, Zierz: Normal protein content but abnormally inhibited enzyme activity in muscle carnitine palmitoyltransferase II deficiency. in Journal of the neurological sciences 2014
CPT1 (show CPT1A ELISA Kits) is active on the outer surface of mitochondria and serves as a regulatory site for fatty acid oxidation due to its sensitivity for malonyl-CoA. CPT1b is the muscle isoform.
In subjects with PTSD, significant over-expression of CPT1B was also observed in the two common dysregulated pathways: fatty acid metabolism and PPAR (show PPARA ELISA Kits).
Differential DNA methylation (show HELLS ELISA Kits) may underlie the depressed expression of CPT1B in response to lipid, contributing to the metabolic inflexibility associated with severe obesity.
E531K substitution in CPT1B decreases the mitochondrial beta-oxidation pathway, which increases the non-protein respiratory quotient value during recovery from exercise.
study identified a novel haplotype consisting of the indel variation, which had not been detected in previous studies in Japanese and Korean populations, and observed four single-nucleotide polymorphisms in CHKB (show CHKB ELISA Kits)/CPT1B
CPT1B heterozygous variants of G320D and S427C among control subjects showed significantly higher levels of total and free carnitine in the blood compared to acute myocardial infarction patients.
present results confirm the association of carnitine palmitoyltransferase 1B coding polymorphisms with the metabolic syndrome
Genetic mutations causative for McArdle disease, carnitine palmitoyl transferase deficiency 2, myoadenylate deaminase (show AMPD1 ELISA Kits) deficiency, and malignant hyperthermia have all been associated with Exertional rhabdomyolysis.
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 (show P2RY11 ELISA Kits) with narcolepsy, but does not confirm the association of CPT1B/CHKB (show CHKB ELISA Kits) (rs5770917) in the Chinese population.
Genetic analysis, comparison, and tissue distribution of CPT1b
Recombinant pig carnitine palmitoyltransferase I (show CPT1A ELISA Kits) beta has unique kinetic characteristics which make it a useful model to study the structure-function relationship of the CPTI enzymes.
Postnatal increases in CPT I activity during the suckling period are accompanied by increased tissue carnitine.
Suppression of CPT1B and induction of SCD (show SCD ELISA Kits) and CEBPB (show CEBPB ELISA Kits) by supplemental arginine promotes increased adiposity in Angus steers.
This study evaluated the effects of nonesterified fatty acids and glucose on carnitine palmitoyltransferase-I (CPT-I) mRNA expression in cultured bovine hepatocytes using real-time reverse transcription polymerase chain reaction and ELISA methods.
Cardiac CPT (show DHDDS ELISA Kits)-1b suppression protects against the aggravation of cardiac morphology and function associated with HFD feeding. CPT (show DHDDS ELISA Kits)-1b represents a potential therapeutic target for the treatment of cardiac dysfunction related to metabolic diseases such as obesity and diabetes.
Data show that peroxisome-proliferator-activated receptor beta (show PPARD ELISA Kits)/delta (PPARbeta (show PPARD ELISA Kits)/delta) activation restored the lipid-induced endothelial dysfunction by up-regulation of carnitine palmitoyltransferase)-1 (CPT-1 (show CPT1A ELISA Kits)).
Data (including data from knockout and chimeric mice) suggest that Cpt1b is involved in myocardial function (but perhaps not in skeletal muscle function); knockout (and presumably inhibition) of Cpt1b results in cardiac hypertrophy and early death.
CPT1b deficiency can cause lipotoxicity in the heart under pathological stress, leading to exacerbation of cardiac pathology.
Data show that HIV protease inhibitors suppress fatty acid oxidation in skeletal muscle cells, which may be related to decreases in cytosolic- and mitochondrial-associated fatty acid transporters such as CD36 (show CD36 ELISA Kits) and carnitine palmitoyltransferase I (show CPT1A ELISA Kits) .
Leptin reduces the sensitivity of cardiac CPT-I to malonyl-CoA.
Cpt1b transcripts are first and temporally detected at the 2-cell stage and reappear at the morula and blastocyst stage
Overall, the M-CPTI promoter was found to be necessary for the tissue-specific hormonal and dietary regulation of the gene expression.
lethality of homozygous CPT (show DHDDS ELISA Kits)-1b deficiency in the mice is consistent with paucity of human cases.
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene.
carnitine O-palmitoyltransferase 1, muscle isoform
, carnitine O-palmitoyltransferase I, mitochondrial muscle isoform
, carnitine palmitoyltransferase I-like protein
, CPT I
, CPT-Ibeta 1
, CPT-Ibeta 3
, Carnitine palmitoyltransferase 1 beta, muscle isoform
, Carnitine palmitoyltransferase 1, muscle
, carnitine O-palmitoyltransferase I, muscle isoform
, carnitine palmitoyltransferase Ibeta 1
, carnitine palmitoyltransferase Ibeta 2
, carnitine palmitoyltransferase Ibeta 3
, carnitine palmitoyl transferase I muscle isoform
, carnitine palmitoyltransferase I
, carnitine palmitoyltransferase 1B
, carnitine palmitoyltransferase 1A like
, carnitine palmitoyltransferase 1B (muscle)
, carnitine palmitoyltransferase 1B-like
, carnitine O-palmitoyltransferase 1, muscle isoform-like
, muscle-type carnitine palmitoyltransferase I