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Browse our Fatty Acid Synthase Proteins (FASN)

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Fatty Acid Synthase Proteins (FASN)
On are 14 Fatty Acid Synthase (FASN) Proteins from 6 different suppliers available. Additionally we are shipping Fatty Acid Synthase Antibodies (129) and Fatty Acid Synthase Kits (54) and many more products for this protein. A total of 204 Fatty Acid Synthase products are currently listed.
A630082H08Rik, anon-EST:Posey43, anon-EST:Posey235, anon-WO0138581.1, BcDNA:gh07626, Cgl0836, dFAS, Dmel\\CG3523, DM_7295848, fas, FASN, Fatty acid synthase, fj34h12, OA-519, SDR27X1, wu:fj34h12
list all proteins Gene Name GeneID UniProt
FASN 2194 P49327
FASN 14104 P19096
FASN 50671 P12785

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Fatty Acid Synthase Proteins (FASN) by Origin

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More Proteins for Fatty Acid Synthase Interaction Partners

Caenorhabditis elegans (C. elegans) Fatty Acid Synthase (FASN) interaction partners

  1. Fasn-1 regulates antimicrobial peptide (show cAMP Proteins) nlp-29 expression in a WNK-1 (show WNK1 Proteins) and gck (show GCK Proteins)-3 dependent manner.

Fruit Fly (Drosophila melanogaster) Fatty Acid Synthase (FASN) interaction partners

  1. Genetic interactions at the cell-autonomous level, where glycolytic enzymes or Glo1 (show GLO1 Proteins) were manipulated in FASN mutant cells, revealed that this sugar-dependent size reduction is a direct consequence of MG-derived-AGE accumulation

Human Fatty Acid Synthase (FASN) interaction partners

  1. concluded that EGFR (show EGFR Proteins) can be activated intracellularly by FASN-dependent palmitoylation

  2. Our results suggest that FASN upregulation and PTEN downregualtion may be involved in peritoneal dissemination for gastric cancer progression.

  3. Data suggest that thioesterase 2 (TE2 (show ARD1A Proteins)) catalytic domain of FASN exhibits novel capping domain insert within the alpha/beta hydrolase core; TE2 (show ARD1A Proteins) (as opposed to TE1 domain) readily releases short chain fatty acids from full-length FASN during turnover.

  4. data demonstrate that selective and potent FASN inhibition with TVB (show RHOBTB2 Proteins)-3166 leads to selective death of tumor cells, without significant effect on normal cells, and inhibits in vivo xenograft tumor growth at well-tolerated doses.

  5. Results showed correlated FASN regulation relative to key signaling genes with tumor invasion and differentiation in primary retinoblastoma (RB) tissues. Its silencing exerted definite anti-cancer effects in RB cells through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.

  6. Findings indicate that overexpression of FASN plays a crucial role in maintaining energy homeostasis in CRC (show CALR Proteins) via increased oxidation of endogenously synthesized lipids.

  7. TG levels are regulated by HCBP6-sterol regulatory element binding protein (show CNBP Proteins) 1c (SREBP1c (show SREBF1 Proteins))-mediated fatty acid synthase (FASN) expression.

  8. Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR (show FRAP1 Proteins) signaling pathway.

  9. In the present study it was determined whether three key enzymes for glycolysis, glutaminolysis and de novo synthesis of FAs (show FAS Proteins), hexokinase-2 (show HK2 Proteins), glutaminase (show GLS Proteins) and fatty acid synthase

  10. FASN and HER2 (show ERBB2 Proteins) have roles in breast cancer and are blocked by EGCG with pertuzumab or temsirolimus

Pig (Porcine) Fatty Acid Synthase (FASN) interaction partners

  1. In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation (show HELLS Proteins) status in the inner layer of backfat from Jinhua pigs at different developmental stages.

  2. calculated a 4.5 angstrom-resolution map of fatty acid synthase, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density

  3. study determined fatty acid synthase crystal structure at 3.2 angstrom resolution covering five catalytic domains; structure reveals a complex architecture of alternating linkers and enzymatic domains

Mouse (Murine) Fatty Acid Synthase (FASN) interaction partners

  1. Inhibition of G-protein-coupled Receptor Kinase 2 (show ADRBK1 Proteins) Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.

  2. These findings suggest that activation of TSHR (show TSHR Proteins) directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK (show EPHB2 Proteins)

  3. UCP2 (show UCP2 Proteins)-induced fatty acid synthase promotes NLRP3 (show NLRP3 Proteins) inflammasome activation during sepsis

  4. FASN plays an important role in exercise-mediated cognitive enhancement, which might be associated to its role in modulating exercise-induced stimulation of neurogenesis.

  5. FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland.

  6. Gamma-tocotrienol showed attenuation of triglyceride through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1 (show SREBF1 Proteins), stearoyl CoA desaturase 1 (show SCD Proteins), and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6 cells.

  7. Upregulation of host hepatic fatty acid synthase correlates with hepatitis B virus replication.

  8. In vivo studies using germline (Creb1 (show CREB1 Proteins)(-/-) ) and lung epithelial-specific (Creb1 (show CREB1 Proteins)(EpiDelta/Delta) ) Creb1 (show CREB1 Proteins) knockout mice showed strongly reduced Scd1 (show SCD Proteins), but not Fasn gene expression and protein levels in lung epithelial cells.

  9. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase (show MAPK14 Proteins), E3 ligase COP1, and SH2-tyrosine phosphatase Shp2 (show PTPN11 Proteins).

  10. fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult neural stem and progenitor cells and conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis

Cow (Bovine) Fatty Acid Synthase (FASN) interaction partners

  1. Results indicate that Fatty acid synthase (FASN) may be used as a candidate gene affecting intramuscular fat content in Datong yaks.

  2. It was suggested that two cattle breeds have an advantage in terms of genotype and haplotype distribution of the FASN gene; a single polymorphism might be a potential marker for breed discrimination.

  3. study evaluated the contributions of polymorphisms of FASN and SCD (show SCD Proteins) genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations

  4. The five exonic single nucleotide polymorphisms of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents.

  5. Results suggest that SCD (show SCD Proteins) and FASN are strong candidate genes influencing fatty acid composition in beef cattle.

  6. The effects of genetic polymorphisms of liver X receptor, alpha (LXR (show NR1H3 Proteins)), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.

  7. In ruminants, FASN may be regulated between the ratio between two transcripts. The small transcript is mostly produced in tissues with low fatty acid synthesis.

  8. Polymorphisms within the FASN gene are associated with milk-fat content.

  9. SNPs in the FASN gene are associated with variation in the fatty acid composition of adipose fat and milk fat.

  10. The four exons in FASN that encode for the TE domain were sequenced, and three SNPs, AF285607:g.17924A>G, g.18663T>C and g.18727C>T, were identified.

Goat Fatty Acid Synthase (FASN) interaction partners

  1. The results suggested that LXR (show NR1H3 Proteins) regulates FASN promoter activity through direct interaction with the LXR (show NR1H3 Proteins) response element as well as through increasing SREBP1 (show SREBF1 Proteins) abundance.

Fatty Acid Synthase (FASN) Protein Profile

Protein Summary

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Alternative names and synonyms associated with Fatty Acid Synthase (FASN)

  • fatty acid synthase (fas)
  • fatty acid synthase Fas (fas)
  • Fatty acid synthase Fas (fas)
  • fatty acid synthase (FASN)
  • fatty acid synthase (fasn)
  • Fatty Acid SyNthase (fasn-1)
  • fatty-acid synthase (NCgl0802)
  • fatty-acid synthase (fas)
  • fatty-acid synthase II (fasB)
  • fatty-acid synthase (MT2600)
  • fatty-acid synthase fas (TBMG_01448)
  • CG3523 gene product from transcript CG3523-RA (CG3523)
  • fatty acid synthase (Fasn)
  • A630082H08Rik protein
  • anon-EST:Posey43 protein
  • anon-EST:Posey235 protein
  • anon-WO0138581.1 protein
  • BcDNA:gh07626 protein
  • Cgl0836 protein
  • dFAS protein
  • Dmel\\CG3523 protein
  • DM_7295848 protein
  • fas protein
  • FASN protein
  • Fatty acid synthase protein
  • fj34h12 protein
  • OA-519 protein
  • SDR27X1 protein
  • wu:fj34h12 protein

Protein level used designations for Fatty Acid Synthase Proteins (FASN)

fatty acid synthase , fatty acid synthase Fas , Fatty acid synthase Fas , FAS , Fatty Acid SyNthase family member (fasn-1) , fatty-acid synthase , fatty-acid synthase II , fatty-acid synthase fas , CG3523-PA , CG3523-PC , fatty acid synthetase , thioesterase , short chain dehydrogenase/reductase family 27X, member 1

1090893 Mycobacterium bovis AF2122/97
4554262 Mycobacterium ulcerans Agy99
4556962 Bifidobacterium adolescentis ATCC 15703
910284 Mycobacterium leprae TN
7327064 Mycobacterium leprae Br4923
8691181 Bifidobacterium dentium Bd1
6228237 Mycobacterium marinum M
454986 Pan troglodytes
335859 Danio rerio
100270775 Felis catus
172715 Caenorhabditis elegans
100025176 Monodelphis domestica
1018831 Corynebacterium glutamicum ATCC 13032
5213489 Mycobacterium tuberculosis H37Ra
887704 Mycobacterium tuberculosis H37Rv
1032088 Corynebacterium efficiens YS-314
923178 Mycobacterium tuberculosis CDC1551
8163219 Mycobacterium tuberculosis KZN 1435
33524 Drosophila melanogaster
396061 Gallus gallus
2194 Homo sapiens
397561 Sus scrofa
14104 Mus musculus
50671 Rattus norvegicus
100714828 Cavia porcellus
281152 Bos taurus
100861286 Capra hircus
483378 Canis lupus familiaris
100170327 Ovis aries
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