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Browse our HNF4A Proteins (HNF4A)

Full name:
Hepatocyte Nuclear Factor 4, alpha Proteins (HNF4A)
On www.antibodies-online.com are 13 Hepatocyte Nuclear Factor 4, alpha (HNF4A) Proteins from 6 different suppliers available. Additionally we are shipping HNF4A Antibodies (187) and HNF4A Kits (18) and many more products for this protein. A total of 237 HNF4A products are currently listed.
Synonyms:
CG9310, dHNF-4, dHNF4, Dmel\\CG9310, DmHNF4, fb58h09, Hnf-4, HNF-4(D), HNF-4alpha, Hnf-4h, hnf4, HNF4A, HNF4a7, HNF4a8, HNF4a9, Hnf4alpha, id:ibd1279, MODY, MODY1, nr2a1, NR2A4, NR2A21, TCF, TCF14, wu:fb58h09
list all proteins Gene Name GeneID UniProt
HNF4A 15378 P49698
HNF4A 25735 P22449
HNF4A 3172 P41235

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HNF4A Proteins (HNF4A) by Origin

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Top referenced HNF4A Proteins

  1. Human HNF4A Protein expressed in Human - ABIN2722902 : Ning, Koh, Pan, Jeong: Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice. in Biochemical pharmacology 2015 (PubMed)

More Proteins for HNF4A Interaction Partners

Fruit Fly (Drosophila melanogaster) Hepatocyte Nuclear Factor 4, alpha (HNF4A) interaction partners

  1. Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 (show SIRT1 Proteins) mutants, and protein levels for dHNF4 are reduced in sir2 (show SIRT1 Proteins) mutant animals. Sir2 (show SIRT1 Proteins) exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.

  2. Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.

Mouse (Murine) Hepatocyte Nuclear Factor 4, alpha (HNF4A) interaction partners

  1. The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP (show MLXIPL Proteins) transcription in response to glucose, and also demonstrated that ChREBP (show MLXIPL Proteins)-alpha and HNF-4alpha synergistically increased ChREBP (show MLXIPL Proteins)-beta transcription.

  2. Berberine has an effect on hepatic gluconeogenesis and lipid metabolism and is mediated through HNF-4alpha and regulated downstream of miR122

  3. Diminished XBP1 (show XBP1 Proteins) and/or HNF4alpha in beta-cells led to impaired endoplasmic reticulum calcium homeostasis.

  4. In conclusion, our study revealed a novel mechanism by which TSH regulated the hepatic HNF-4alpha subcellular localization.

  5. an integrated analytic strategy was applied to identify the HNF4alpha-centered regulatory network.

  6. Tfr2 (show TFR2 Proteins) is a novel target gene for HNF4alpha, and hepatic HNF4alpha plays a critical role in iron homeostasis.

  7. The miR-34a-HNF4alpha pathway is activated under common conditions of metabolic stress and may have a role in the pathogenesis of NAFLD and in regulating plasma lipoprotein metabolism.

  8. FOXA3 (show FOXA3 Proteins) and HNF4alpha are powerful transcription factors for inducing rat bone marrow mesenchymal stem cells to differentiate into functional hepatocyte-like cells.

  9. HNF4a is involved in the downregulation of SHBG (show SHBG Proteins) during obesity development.

  10. Results showed that HNF4a is highly expressed in brain of mouse model of major depression suggesting that this gene may be both essential for life and have a critical impact on physiological homeostasis under depressive status.

Human Hepatocyte Nuclear Factor 4, alpha (HNF4A) interaction partners

  1. HNF4A mutations can be associated with Maturity Onset Diabetes of the Young and Congenital Hyperinsulinism. Dual phenotype observed in the neonatal period progressing to diabetes in adulthood with prolonged episodes of hypoglycaemia.

  2. The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP (show MLXIPL Proteins) transcription in response to glucose, and also demonstrated that ChREBP (show MLXIPL Proteins)-alpha and HNF-4alpha synergistically increased ChREBP (show MLXIPL Proteins)-beta transcription.

  3. the results identify Exo70 (show EXOC7 Proteins) as a novel transcriptional target of HNF4alpha to promote cell cycle progression in hepatoma, thus provide a basis for the development of therapeutic strategies for hepatocellular carcinoma.

  4. The present study aimed to explore the association between single nucleotide polymorphisms (SNPs) in the hepatocyte nuclear factor4alpha (HNF4alpha) gene and the incidence of type 2 diabetes in the Chinese Bai population in Dali city, China.

  5. SNPs at the CETP (show CETP Proteins), HNF4A and KLF14 (show SP6 Proteins) locus are associated with HDL (show HSD11B1 Proteins)-C levels and type 2 diabetes (in female participants).

  6. The HNF1A (show HNF1A Proteins) gene encodes the transcription factor hepatocyte nuclear factor-1alpha (show HNF1A Proteins) (HNF1alpha (show HNF1A Proteins)), which is expressed in many different tissues, including the liver

  7. Mutations in HNF4A and HNF1A (show HNF1A Proteins) genes might account for this early-onset inherited type 2 diabetes.

  8. HNF4alpha expression analysis revealed that pre-exposing the cells with FGF4 (show FGF4 Proteins) was more effective in hepatocyte differentiation.

  9. PHD2 (show EGLN1 Proteins) suppresses the activity of TGF-beta1 (show TGFB1 Proteins) pathway and consequently maintains the expression of hepatocyte nuclear factor-4alpha

  10. rejected the hypothesis that all human MODY-associated mutations in HNF1A (show HNF1A Proteins) / HNF4A induce changes in the pharmacokinetics of sulfonylureas in humans analogically to the Hnf1a (show HNF1A Proteins)(-/-) mouse model

Pig (Porcine) Hepatocyte Nuclear Factor 4, alpha (HNF4A) interaction partners

  1. HNF4 positively regulates pUPII gene promoter activity.

Cow (Bovine) Hepatocyte Nuclear Factor 4, alpha (HNF4A) interaction partners

  1. Tetra-primer ARMS-PCR identifies the novel genetic variations of bovine HNF-4alpha gene associating with growth traits.

  2. Results show that chicken ovalbumin upstream promoter transcription factor (show NR2F1 Proteins) II (COUP-TFII (show NR2F2 Proteins)), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor (show GHR Proteins) 1A promoter activity through binding to a common DNA element

HNF4A Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Alternative names and synonyms associated with HNF4A

  • hepatocyte nuclear factor 4, alpha (HNF4A)
  • hepatocyte nuclear factor 4, alpha (hnf4a)
  • Hepatocyte nuclear factor 4 (Hnf4)
  • hepatic nuclear factor 4, alpha (Hnf4a)
  • hepatocyte nuclear factor 4 alpha (LOC100345457)
  • hepatocyte nuclear factor 4, alpha (Hnf4a)
  • CG9310 protein
  • dHNF-4 protein
  • dHNF4 protein
  • Dmel\\CG9310 protein
  • DmHNF4 protein
  • fb58h09 protein
  • Hnf-4 protein
  • HNF-4(D) protein
  • HNF-4alpha protein
  • Hnf-4h protein
  • hnf4 protein
  • HNF4A protein
  • HNF4a7 protein
  • HNF4a8 protein
  • HNF4a9 protein
  • Hnf4alpha protein
  • id:ibd1279 protein
  • MODY protein
  • MODY1 protein
  • nr2a1 protein
  • NR2A4 protein
  • NR2A21 protein
  • TCF protein
  • TCF14 protein
  • wu:fb58h09 protein

Protein level used designations for HNF4A

hepatocyte nuclear factor 4 alpha , hepatocyte nuclear factor 4, alpha , hepatocyte nuclear factor 4-alpha-like , hepatocyte nuclear factor 4-alpha , CG9310-PA , CG9310-PB , CG9310-PD , CG9310-PE , Hnf4-PA , Hnf4-PB , Hnf4-PD , Hnf4-PE , hepatocyte nuclear factor 4 , hepatocyte nuclear factor 4 homologue , HNF-4-alpha , HNF4 alpha , HNF4alpha10 , HNF4alpha11 , HNF4alpha12 , Nuclear receptor 2A1 , TCF-14 , nuclear receptor subfamily 2 group A member 1 , transcription factor 14 , transcription factor HNF-4 , alpha transcription factor 4 , hepatic nuclear factor 4, alpha , HNF4alpha10/11/12 , hepatic nuclear factor 4 alpha , hepatic nuclear factor 4 , NR2A1 , hepatic nuclear factor 4alpha , nuclear receptor

GENE ID SPECIES
458269 Pan troglodytes
100023834 Monodelphis domestica
100056007 Equus caballus
100402825 Callithrix jacchus
100528306 Ictalurus punctatus
100534656 Ovis aries
100593478 Nomascus leucogenys
44544 Drosophila melanogaster
15378 Mus musculus
100345457 Oryctolagus cuniculus
25735 Rattus norvegicus
3172 Homo sapiens
485884 Canis lupus familiaris
733636 Sus scrofa
509200 Bos taurus
322358 Danio rerio
379762 Xenopus laevis
100713275 Cavia porcellus
419198 Gallus gallus
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