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Browse our anti-LKB1 (STK11) Antibodies

Full name:
anti-serine/threonine Kinase 11 Antibodies (STK11)
On www.antibodies-online.com are 352 serine/threonine Kinase 11 (STK11) Antibodies from 29 different suppliers available. Additionally we are shipping LKB1 Kits (19) and LKB1 Proteins (12) and many more products for this protein. A total of 409 LKB1 products are currently listed.
Synonyms:
AA408040, hLKB1, Lkb1, mLKB1, Par-4, PJS, R75140, Stk11, wu:fj61a05, xeek1, zgc:110180
list all antibodies Gene Name GeneID UniProt
STK11 6794 Q15831
STK11 20869 Q9WTK7
STK11 314621  

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Most Popular Reactivities for anti-LKB1 (STK11) Antibodies

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anti-Human LKB1 Antibodies:

anti-Mouse (Murine) LKB1 Antibodies:

anti-Rat (Rattus) LKB1 Antibodies:

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Top referenced anti-LKB1 Antibodies

  1. Human Polyclonal LKB1 Primary Antibody for IHC (p), WB - ABIN303290 : Shaw, Bardeesy, Manning, Lopez, Kosmatka, DePinho, Cantley: The LKB1 tumor suppressor negatively regulates mTOR signaling. in Cancer cell 2004 (PubMed)
    Show all 9 references for ABIN303290

  2. Human Polyclonal LKB1 Primary Antibody for EIA, WB - ABIN359444 : Martínez-Torrecuadrada, Romero, Núñez, Alfonso, Sánchez-Céspedes, Casal: An efficient expression system for the production of functionally active human LKB1. in Journal of biotechnology 2004 (PubMed)
    Show all 4 references for ABIN359444

  3. Human Polyclonal LKB1 Primary Antibody for FACS, IF - ABIN391352 : Suzuki, Kusakai, Kishimoto, Shimojo, Ogura, Lavin, Esumi: IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 3 references for ABIN391352

  4. Human Monoclonal LKB1 Primary Antibody for FACS, ELISA - ABIN969424 : Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: Spinal cord injury detection and monitoring using spectral coherence. in IEEE transactions on bio-medical engineering 2009 (PubMed)
    Show all 3 references for ABIN969424

  5. Human Polyclonal LKB1 Primary Antibody for EIA, IHC (p) - ABIN4620396 : Shaw, Kosmatka, Bardeesy, Hurley, Witters, DePinho, Cantley: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 3 references for ABIN4620396

  6. Human Polyclonal LKB1 Primary Antibody for IHC (p), WB - ABIN1537707 : Howard, Panchal, McCarthy, Ashworth: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. in Genes & development 2005 (PubMed)
    Show all 2 references for ABIN1537707

  7. Chicken Polyclonal LKB1 Primary Antibody for IHC, WB - ABIN2776968 : Xie, Dong, Zhang, Cui, Cohen, Riek, Neumann, Schlattner, Zou: Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. in The Journal of biological chemistry 2006 (PubMed)

  8. Human Polyclonal LKB1 Primary Antibody for IF (p), IHC (p) - ABIN751573 : Wang, Zhao, Yu, Feng, Zhang, Kou, Chu, Cui, Li, Zhang, Shen, Min: Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis. in Toxicology and applied pharmacology 2016 (PubMed)

  9. Human Polyclonal LKB1 Primary Antibody for FACS, IF - ABIN391350 : Sohn, Jang, Campan, Weisenberger, Dickhout, Wang, Cho, Yates, Lucock, Chiang, Austin, Choi, Laird, Kim et al.: The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer ... in International journal of cancer. Journal international du cancer 2009 (PubMed)

More Antibodies against LKB1 Interaction Partners

Human serine/threonine Kinase 11 (STK11) interaction partners

  1. Data provide evidence for three novel mutations and three recurrent mutations in STK11 were identified in Chinese families with Peutz-Jeghers syndrome, which further broaden the mutation spectrum of STK11.

  2. The mutation detection rate for the LKB1 gene was 85.7% in our Chinese familial Peutz-Jeghers Syndrome and 63.2% in all Chinese Peutz-Jeghers Syndrome patients. The amplification and sequencing results of the flanking sequences presented 3 kinds of polymorphisms in introns of LKB1 gene: (c.374+24G>T, c.464+47_48inGGGGGCC, and c.920+7G>C).

  3. STK11 mutation in gastric in gastric-type endocervical adenocarcinoma is associated with worse prognosis.

  4. identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth

  5. Severely compromised endogenous LKB1 expression in the L02 cell line may confer to L02 cells tumor-initiating capacities.

  6. AMPK (show PRKAA1 Antibodies) exerts multiple actions on TGF-beta (show TGFB1 Antibodies) signaling and supports that AMPK (show PRKAA1 Antibodies) can serve as a therapeutic drug target for breast cancer

  7. Case Report: STK11 gene mutation as the primary cause of Peutz-Jeghers syndrome in 9 month old Chinese infant.

  8. A combination of kinase-dependent and independent defects by LKB1 inactivation creates a uniquely invasive cell with aberrant polarity and adhesion signaling that drives invasion into the microenvironment.

  9. LKB1 expression was reduced in gastric adenocarcinoma tissues but it correlated positively with better prognosis for gastric cancer patients. LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap (show YAP1 Antibodies) and beta-catenin (show CTNNB1 Antibodies).

  10. Decreased LKB1 expression is associated with metastatic endometrial and lung cancers.

Mouse (Murine) serine/threonine Kinase 11 (STK11) interaction partners

  1. LKB1 complex proteins have a role in myofilament function and myocellular "energy" sensing in the heart

  2. identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth

  3. The lack of LKB1 in skeletal muscle leads to an increased inflammatory state.

  4. Partial deficiency of cardiac LKB1 promotes the adverse effects of a high-fat, high-sucrose diet on the myocardium, leading to worsening of diastolic function and the de novo appearance of systolic dysfunction.

  5. Rapid activation of AMPK (show PRKAA1 Antibodies) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 activation but not increased intracellular AMP (show TMPRSS5 Antibodies) levels or CaMKKbeta activation.

  6. We proposed that LKB1 regulates cerebellar development by controlling GCPs proliferation through Shh (show SHH Antibodies) signalling during cerebellar development.

  7. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

  8. LKB1 promotes maturation of bile ducts during biliary morphogenesis.LKB1 and Notch (show NOTCH1 Antibodies) share a common genetic program in the liver, and regulate bile duct morphogenesis.

  9. STK11/LKB1-inactivating mutations were associated with reduced expression of PD-1 (show PDCD1 Antibodies) ligand PD-L1 (show CD274 Antibodies) in mouse and patient tumors as well as in tumor-derived cell lines.

  10. activation of AKT (show AKT1 Antibodies) and mTORC1, the double knockout of PTEN (show PTEN Antibodies) and LKB1 contributes to distinct cell-specific aspects of tumor development and progression.

Zebrafish serine/threonine Kinase 11 (STK11) interaction partners

  1. inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (show PDK2 Antibodies) expression and inactivates pyruvate dehydrogenase (show PDK2 Antibodies) complex by increasing phosphorylation of pyruvate dehydrogenase (show PDK2 Antibodies).

  2. A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.

  3. Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.

Pig (Porcine) serine/threonine Kinase 11 (STK11) interaction partners

  1. Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.

LKB1 (STK11) Antigen Profile

Antigen Summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with LKB1 (STK11)

  • serine/threonine kinase 11 (STK11) antibody
  • serine/threonine kinase 11 (stk11) antibody
  • polarization-related protein LKB1 (lkb1) antibody
  • serine/threonine kinase 11 (Stk11) antibody
  • AA408040 antibody
  • hLKB1 antibody
  • Lkb1 antibody
  • mLKB1 antibody
  • Par-4 antibody
  • PJS antibody
  • R75140 antibody
  • Stk11 antibody
  • wu:fj61a05 antibody
  • xeek1 antibody
  • zgc:110180 antibody

Protein level used designations for STK11

serine/threonine protein kinase 11 , serine/threonine kinase 11 (Peutz-Jeghers syndrome) , GLEAN_12166 , Serine/threonine-protein kinase 11 , serine/threonine-protein kinase STK11 , serine/threonine kinase 11 , serine/threonine-protein kinase 11-like , liver kinase B1 , polarization-related protein LKB1 , renal carcinoma antigen NY-REN-19 , serine/threonine-protein kinase 11 , serine/threonine-protein kinase LKB1 , LKB1 short isoform , liver kinase B1 homolog , lkb1 , egg and embryo kinase 1 , serine/threonine-protein kinase XEEK1 , serine/threonine-protein kinase stk11

GENE ID SPECIES
468641 Pan troglodytes
549287 Xenopus (Silurana) tropicalis
662493 Tribolium castaneum
705686 Macaca mulatta
100022246 Monodelphis domestica
100055913 Equus caballus
100460337 Pongo abelii
100477412 Ailuropoda melanoleuca
6794 Homo sapiens
20869 Mus musculus
550537 Danio rerio
399100 Xenopus laevis
420105 Gallus gallus
485088 Canis lupus familiaris
515245 Bos taurus
314621 Rattus norvegicus
100512213 Sus scrofa
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