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anti-Human LKB1 Antibodies:
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Human Monoclonal LKB1 Primary Antibody for FACS, ELISA - ABIN969424
Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: Spinal cord injury detection and monitoring using spectral coherence. in IEEE transactions on bio-medical engineering 2009
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Human Polyclonal LKB1 Primary Antibody for IHC (p), WB - ABIN1537707
Howard, Panchal, McCarthy, Ashworth: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. in Genes & development 2005
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Human Polyclonal LKB1 Primary Antibody for IF (p), IHC (p) - ABIN751573
Wang, Zhao, Yu, Feng, Zhang, Kou, Chu, Cui, Li, Zhang, Shen, Min: Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis. in Toxicology and applied pharmacology 2016
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Human Polyclonal LKB1 Primary Antibody for ELISA, WB - ABIN1002745
Boudeau, Baas, Deak, Morrice, Kieloch, Schutkowski, Prescott, Clevers, Alessi: MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. in The EMBO journal 2003
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Human Polyclonal LKB1 Primary Antibody for FACS, IF - ABIN391350
Sohn, Jang, Campan, Weisenberger, Dickhout, Wang, Cho, Yates, Lucock, Chiang, Austin, Choi, Laird, Kim et al.: The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer ... in International journal of cancer. Journal international du cancer 2009
Human Polyclonal LKB1 Primary Antibody for IHC (p), WB - ABIN966488
Jenne, Reimann, Nezu, Friedel, Loff, Jeschke, Müller, Back, Zimmer: Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. in Nature genetics 1998
Human Polyclonal LKB1 Primary Antibody for ICC, IF - ABIN4331209
Co, Iglesias, Celestino, Kwan, Mok, Schmandt, Lu: Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53. in Cancer 2014
Molecular analyses of HNK-treated xenografts corroborated our in vitro mechanistic findings. Collectively, these results present the first in vitro and in vivo evidence to support crosstalk between LKB1, Stat3 (show STAT3 Antibodies) and pluripotency factors in breast cancer and effective anticancer modulation of this axis with HNK treatment.
E6 upregulation of hTERT by downregulated LKB1 and upregulated SP1 (show PSG1 Antibodies) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Macrophage LKB1 reduction caused by oxidized low-density lipoprotein promotes foam cell formation and the progression of atherosclerosis.
CPS1 (show CPS1 Antibodies) maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
All together our results show that STK11ex1-2 mutations delineate an aggressive subtype of lung cancer for which a targeted treatment through STK11 inhibition might offer new opportunities.
Low LKB1 expression is associated with HPV-associated cervical cancer progression.
Mutations in TP53 and STK11 also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 with suppression of immune surveillance. These findings illustrate the remarkably distinct ways through which tumor suppressor mutations may contribute to heterogeneity in KRAS-mutant tumor biology.
Studies indicate that the serine-threonine kinase 11 (Peutz-Jeghers syndrome) LKB1 gene is somatically mutated in female reproductive tract cancers.
Our results indicate that HPV16 E6/E7 indirectly upregulated the expression of VEGF by inhibition of liver kinase B1 expression and upregulation of hypoxia-inducible factor 2alpha expression,thus propose a human papillomavirus-liver kinase B1-hypoxia-inducible factor 2A-vascular endothelial growth factor axis for the tumorigenesis of lung cancer
The expression of LKB1 is down-regulated in most of the lung cell lines.
Findings indicate that the energy-sensing LKB1-AMPK (show PRKAA1 Antibodies) pathway regulates IGF1 (show IGF1 Antibodies) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (show IGF1R Antibodies)-PKB (show AKT2 Antibodies) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1-AMPK (show PRKAA1 Antibodies) mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
this study identified the molecular mechanism of increased angiogenesis and tumor growth with LKB1 deficiency
These results suggest that although physiologic LKB1 expression exerts a potent pro-survival effect in lymphocytes, LKB1 inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.
These results suggest that the LKB1-AMPK (show PRKAA1 Antibodies)-FoxO1 (show FOXO1 Antibodies) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
Lkb1 activates the Notch (show NOTCH1 Antibodies) signaling pathway, which subsequently increases Pax7 (show PAX7 Antibodies) expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch (show NOTCH1 Antibodies) activation through AMPK (show PRKAA1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway in myoblasts.
mitochondrial dysfunction triggers LKB1-mediated AMPK (show PRKAA1 Antibodies) activation, which stimulates Sirt2 (show SIRT2 Antibodies) phosphorylation, leading to activation of mTOR (show FRAP1 Antibodies)-RAPTOR (show RPTOR Antibodies) and Glut1 (show SLC2A1 Antibodies)-mediated glucose uptake.
these data demonstrated that LKB1/AMPK (show PRKAA1 Antibodies) signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1/AMPK (show PRKAA1 Antibodies) signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.
Data show that the serine/threonine kinase (show CDK4 Antibodies) LKB1 regulates mitochondrial calcium uniporter (MCU (show MCU Antibodies))-expression, mitochondria-dependent Ca2 (show CA2 Antibodies)+ clearance, and thereby, presynaptic release properties.
LKB1 deficiency in LKB1(Pax2 (show PAX2 Antibodies)) CKO mice disrupted hair cell planar polarity during embryonic development. The results suggest that LKB1 is required in planar cell polarity formation in cochlear hair cells in mice.
inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (show PDK2 Antibodies) expression and inactivates pyruvate dehydrogenase (show PDK2 Antibodies) complex by increasing phosphorylation of pyruvate dehydrogenase (show PDK2 Antibodies).
A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.
Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.
Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
serine/threonine protein kinase 11
, serine/threonine kinase 11 (Peutz-Jeghers syndrome)
, Serine/threonine-protein kinase 11
, serine/threonine-protein kinase STK11
, serine/threonine kinase 11
, serine/threonine-protein kinase 11-like
, liver kinase B1
, polarization-related protein LKB1
, renal carcinoma antigen NY-REN-19
, serine/threonine-protein kinase 11
, serine/threonine-protein kinase LKB1
, LKB1 short isoform
, liver kinase B1 homolog
, egg and embryo kinase 1
, serine/threonine-protein kinase XEEK1
, serine/threonine-protein kinase stk11