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Browse our LKB1 Proteins (STK11)

Full name:
serine/threonine Kinase 11 Proteins (STK11)
On are 12 serine/threonine Kinase 11 (STK11) Proteins from 6 different suppliers available. Additionally we are shipping LKB1 Antibodies (342) and LKB1 Kits (18) and many more products for this protein. A total of 398 LKB1 products are currently listed.
AA408040, hLKB1, Lkb1, mLKB1, Par-4, PJS, R75140, Stk11, wu:fj61a05, xeek1, zgc:110180
list all proteins Gene Name GeneID UniProt
STK11 6794 Q15831
STK11 20869 Q9WTK7
STK11 314621  

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LKB1 Proteins (STK11) by Origin

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More Proteins for LKB1 Interaction Partners

Human serine/threonine Kinase 11 (STK11) interaction partners

  1. Severely compromised endogenous LKB1 expression in the L02 cell line may confer to L02 cells tumor-initiating capacities.

  2. AMPK (show PRKAA1 Proteins) exerts multiple actions on TGF-beta (show TGFB1 Proteins) signaling and supports that AMPK (show PRKAA1 Proteins) can serve as a therapeutic drug target for breast cancer

  3. Case Report: STK11 gene mutation as the primary cause of Peutz-Jeghers syndrome in 9 month old Chinese infant.

  4. A combination of kinase-dependent and independent defects by LKB1 inactivation creates a uniquely invasive cell with aberrant polarity and adhesion signaling that drives invasion into the microenvironment.

  5. LKB1 expression was reduced in gastric adenocarcinoma tissues but it correlated positively with better prognosis for gastric cancer patients. LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap (show YAP1 Proteins) and beta-catenin (show CTNNB1 Proteins).

  6. Decreased LKB1 expression is associated with metastatic endometrial and lung cancers.

  7. Data show that protein kinase (show CDK7 Proteins) LKB1 physically interacts with BMP type I receptors and requires Smad7 (show SMAD7 Proteins) protein to promote downregulation of the receptor.

  8. Our study results indicate that LKB1 expression is not prognostic in the whole population of breast cancer patients, but it is a potential predictor of OS in the subset of HER2 (show ERBB2 Proteins)-positive patients.

  9. we present two elderly patients with thyroid carcinoma harboring STK11 mutation without clinical manifestation of Peutz-Jeghers syndrome. The findings suggest that STK11 may play a role in thyroid carcinoma development.

  10. Results show the expression of LKB1 mRNA and protein lower in gastric-cancer cell lines and tumor tissues compared to normal gastric cells correlated with poor prognosis with a lower survival rate.

Mouse (Murine) serine/threonine Kinase 11 (STK11) interaction partners

  1. The lack of LKB1 in skeletal muscle leads to an increased inflammatory state.

  2. Partial deficiency of cardiac LKB1 promotes the adverse effects of a high-fat, high-sucrose diet on the myocardium, leading to worsening of diastolic function and the de novo appearance of systolic dysfunction.

  3. Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.

  4. We proposed that LKB1 regulates cerebellar development by controlling GCPs proliferation through Shh (show SHH Proteins) signalling during cerebellar development.

  5. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

  6. LKB1 promotes maturation of bile ducts during biliary morphogenesis.LKB1 and Notch (show NOTCH1 Proteins) share a common genetic program in the liver, and regulate bile duct morphogenesis.

  7. STK11/LKB1-inactivating mutations were associated with reduced expression of PD-1 (show PDCD1 Proteins) ligand PD-L1 (show CD274 Proteins) in mouse and patient tumors as well as in tumor-derived cell lines.

  8. activation of AKT (show AKT1 Proteins) and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression.

  9. we show that loss of LKB1 in renal tubular epithelial cells has an important role in kidney disease development by influencing intracellular metabolism

  10. The LKB1 K178R SUMO mutant had defective AMPK (show PRKAA1 Proteins) signaling and mitochondrial function, inducing death in energy-deprived cells.

Zebrafish serine/threonine Kinase 11 (STK11) interaction partners

  1. A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.

  2. Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.

Pig (Porcine) serine/threonine Kinase 11 (STK11) interaction partners

  1. Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.

LKB1 (STK11) Protein Profile

Protein Summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with LKB1 (STK11)

  • serine/threonine kinase 11 (STK11)
  • serine/threonine kinase 11 (stk11)
  • polarization-related protein LKB1 (lkb1)
  • serine/threonine kinase 11 (Stk11)
  • AA408040 protein
  • hLKB1 protein
  • Lkb1 protein
  • mLKB1 protein
  • Par-4 protein
  • PJS protein
  • R75140 protein
  • Stk11 protein
  • wu:fj61a05 protein
  • xeek1 protein
  • zgc:110180 protein

Protein level used designations for STK11

serine/threonine protein kinase 11 , serine/threonine kinase 11 (Peutz-Jeghers syndrome) , GLEAN_12166 , Serine/threonine-protein kinase 11 , serine/threonine-protein kinase STK11 , serine/threonine kinase 11 , serine/threonine-protein kinase 11-like , liver kinase B1 , polarization-related protein LKB1 , renal carcinoma antigen NY-REN-19 , serine/threonine-protein kinase 11 , serine/threonine-protein kinase LKB1 , LKB1 short isoform , liver kinase B1 homolog , lkb1 , egg and embryo kinase 1 , serine/threonine-protein kinase XEEK1 , serine/threonine-protein kinase stk11

468641 Pan troglodytes
549287 Xenopus (Silurana) tropicalis
662493 Tribolium castaneum
705686 Macaca mulatta
100022246 Monodelphis domestica
100055913 Equus caballus
100460337 Pongo abelii
100477412 Ailuropoda melanoleuca
6794 Homo sapiens
20869 Mus musculus
550537 Danio rerio
399100 Xenopus laevis
420105 Gallus gallus
485088 Canis lupus familiaris
515245 Bos taurus
314621 Rattus norvegicus
100512213 Sus scrofa
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