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Browse our LKB1 Proteins (STK11)

Full name:
serine/threonine Kinase 11 Proteins (STK11)
On www.antibodies-online.com are 12 serine/threonine Kinase 11 (STK11) Proteins from 6 different suppliers available. Additionally we are shipping LKB1 Antibodies (352) and LKB1 Kits (19) and many more products for this protein. A total of 409 LKB1 products are currently listed.
Synonyms:
AA408040, hLKB1, Lkb1, mLKB1, Par-4, PJS, R75140, Stk11, wu:fj61a05, xeek1, zgc:110180
list all proteins Gene Name GeneID UniProt
STK11 6794 Q15831
STK11 20869 Q9WTK7
STK11 314621  

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LKB1 Proteins (STK11) by Origin

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Human serine/threonine Kinase 11 (STK11) interaction partners

  1. Data provide evidence for three novel mutations and three recurrent mutations in STK11 were identified in Chinese families with Peutz-Jeghers syndrome, which further broaden the mutation spectrum of STK11.

  2. The mutation detection rate for the LKB1 gene was 85.7% in our Chinese familial Peutz-Jeghers Syndrome and 63.2% in all Chinese Peutz-Jeghers Syndrome patients. The amplification and sequencing results of the flanking sequences presented 3 kinds of polymorphisms in introns of LKB1 gene: (c.374+24G>T, c.464+47_48inGGGGGCC, and c.920+7G>C).

  3. STK11 mutation in gastric in gastric-type endocervical adenocarcinoma is associated with worse prognosis.

  4. identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth

  5. Severely compromised endogenous LKB1 expression in the L02 cell line may confer to L02 cells tumor-initiating capacities.

  6. AMPK (show PRKAA1 Proteins) exerts multiple actions on TGF-beta (show TGFB1 Proteins) signaling and supports that AMPK (show PRKAA1 Proteins) can serve as a therapeutic drug target for breast cancer

  7. Case Report: STK11 gene mutation as the primary cause of Peutz-Jeghers syndrome in 9 month old Chinese infant.

  8. A combination of kinase-dependent and independent defects by LKB1 inactivation creates a uniquely invasive cell with aberrant polarity and adhesion signaling that drives invasion into the microenvironment.

  9. LKB1 expression was reduced in gastric adenocarcinoma tissues but it correlated positively with better prognosis for gastric cancer patients. LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap (show YAP1 Proteins) and beta-catenin (show CTNNB1 Proteins).

  10. Decreased LKB1 expression is associated with metastatic endometrial and lung cancers.

Mouse (Murine) serine/threonine Kinase 11 (STK11) interaction partners

  1. LKB1 complex proteins have a role in myofilament function and myocellular "energy" sensing in the heart

  2. identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth

  3. The lack of LKB1 in skeletal muscle leads to an increased inflammatory state.

  4. Partial deficiency of cardiac LKB1 promotes the adverse effects of a high-fat, high-sucrose diet on the myocardium, leading to worsening of diastolic function and the de novo appearance of systolic dysfunction.

  5. Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.

  6. We proposed that LKB1 regulates cerebellar development by controlling GCPs proliferation through Shh (show SHH Proteins) signalling during cerebellar development.

  7. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

  8. LKB1 promotes maturation of bile ducts during biliary morphogenesis.LKB1 and Notch (show NOTCH1 Proteins) share a common genetic program in the liver, and regulate bile duct morphogenesis.

  9. STK11/LKB1-inactivating mutations were associated with reduced expression of PD-1 (show PDCD1 Proteins) ligand PD-L1 (show CD274 Proteins) in mouse and patient tumors as well as in tumor-derived cell lines.

  10. activation of AKT (show AKT1 Proteins) and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression.

Zebrafish serine/threonine Kinase 11 (STK11) interaction partners

  1. inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (show PDK2 Proteins) expression and inactivates pyruvate dehydrogenase (show PDK2 Proteins) complex by increasing phosphorylation of pyruvate dehydrogenase (show PDK2 Proteins).

  2. A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.

  3. Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.

Pig (Porcine) serine/threonine Kinase 11 (STK11) interaction partners

  1. Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.

LKB1 (STK11) Protein Profile

Protein Summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with LKB1 (STK11)

  • serine/threonine kinase 11 (STK11)
  • serine/threonine kinase 11 (stk11)
  • polarization-related protein LKB1 (lkb1)
  • serine/threonine kinase 11 (Stk11)
  • AA408040 protein
  • hLKB1 protein
  • Lkb1 protein
  • mLKB1 protein
  • Par-4 protein
  • PJS protein
  • R75140 protein
  • Stk11 protein
  • wu:fj61a05 protein
  • xeek1 protein
  • zgc:110180 protein

Protein level used designations for STK11

serine/threonine protein kinase 11 , serine/threonine kinase 11 (Peutz-Jeghers syndrome) , GLEAN_12166 , Serine/threonine-protein kinase 11 , serine/threonine-protein kinase STK11 , serine/threonine kinase 11 , serine/threonine-protein kinase 11-like , liver kinase B1 , polarization-related protein LKB1 , renal carcinoma antigen NY-REN-19 , serine/threonine-protein kinase 11 , serine/threonine-protein kinase LKB1 , LKB1 short isoform , liver kinase B1 homolog , lkb1 , egg and embryo kinase 1 , serine/threonine-protein kinase XEEK1 , serine/threonine-protein kinase stk11

GENE ID SPECIES
468641 Pan troglodytes
549287 Xenopus (Silurana) tropicalis
662493 Tribolium castaneum
705686 Macaca mulatta
100022246 Monodelphis domestica
100055913 Equus caballus
100460337 Pongo abelii
100477412 Ailuropoda melanoleuca
6794 Homo sapiens
20869 Mus musculus
550537 Danio rerio
399100 Xenopus laevis
420105 Gallus gallus
485088 Canis lupus familiaris
515245 Bos taurus
314621 Rattus norvegicus
100512213 Sus scrofa
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