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STK11 mutation is associated with Lung Adenocarcinoma.
Case Report: novel heterozygous mutation (c.426-448delCGTGCCGGAGAAGCGTTTCCCAG,p.S142SfsX13) in the STK11 gene causing PJS in a Chinese female without a Peutz-Jeghers syndrome family history.
Low LKB1 expression is associated with non-small cell lung cancer.
Molecular analyses of HNK-treated xenografts corroborated our in vitro mechanistic findings. Collectively, these results present the first in vitro and in vivo evidence to support crosstalk between LKB1, Stat3 (show STAT3 Proteins) and pluripotency factors in breast cancer and effective anticancer modulation of this axis with HNK treatment.
E6 upregulation of hTERT by downregulated LKB1 and upregulated SP1 (show PSG1 Proteins) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Macrophage LKB1 reduction caused by oxidized low-density lipoprotein promotes foam cell formation and the progression of atherosclerosis.
CPS1 (show CPS1 Proteins) maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
All together our results show that STK11ex1-2 mutations delineate an aggressive subtype of lung cancer for which a targeted treatment through STK11 inhibition might offer new opportunities.
Low LKB1 expression is associated with HPV-associated cervical cancer progression.
Mutations in TP53 and STK11 also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 with suppression of immune surveillance. These findings illustrate the remarkably distinct ways through which tumor suppressor mutations may contribute to heterogeneity in KRAS-mutant tumor biology.
miR-17-92-dependent tuning of LKB1 levels regulates both the metabolic potential of Myc (show MYC Proteins)+ lymphomas and tumor growth in vivo.
Findings indicate that the energy-sensing LKB1-AMPK (show PRKAA1 Proteins) pathway regulates IGF1 (show IGF1 Proteins) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (show IGF1R Proteins)-PKB (show AKT2 Proteins) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1-AMPK (show PRKAA1 Proteins) mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
this study identified the molecular mechanism of increased angiogenesis and tumor growth with LKB1 deficiency
These results suggest that although physiologic LKB1 expression exerts a potent pro-survival effect in lymphocytes, LKB1 inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.
These results suggest that the LKB1-AMPK (show PRKAA1 Proteins)-FoxO1 (show FOXO1 Proteins) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
Lkb1 activates the Notch (show NOTCH1 Proteins) signaling pathway, which subsequently increases Pax7 (show PAX7 Proteins) expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch (show NOTCH1 Proteins) activation through AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathway in myoblasts.
mitochondrial dysfunction triggers LKB1-mediated AMPK (show PRKAA1 Proteins) activation, which stimulates Sirt2 (show SIRT2 Proteins) phosphorylation, leading to activation of mTOR (show FRAP1 Proteins)-RAPTOR (show RPTOR Proteins) and Glut1 (show SLC2A1 Proteins)-mediated glucose uptake.
these data demonstrated that LKB1/AMPK (show PRKAA1 Proteins) signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1/AMPK (show PRKAA1 Proteins) signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.
Data show that the serine/threonine kinase (show CDK4 Proteins) LKB1 regulates mitochondrial calcium uniporter (MCU (show MCU Proteins))-expression, mitochondria-dependent Ca2 (show CA2 Proteins)+ clearance, and thereby, presynaptic release properties.
inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (show PDK2 Proteins) expression and inactivates pyruvate dehydrogenase (show PDK2 Proteins) complex by increasing phosphorylation of pyruvate dehydrogenase (show PDK2 Proteins).
A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.
Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.
Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
serine/threonine protein kinase 11
, serine/threonine kinase 11 (Peutz-Jeghers syndrome)
, Serine/threonine-protein kinase 11
, serine/threonine-protein kinase STK11
, serine/threonine kinase 11
, serine/threonine-protein kinase 11-like
, liver kinase B1
, polarization-related protein LKB1
, renal carcinoma antigen NY-REN-19
, serine/threonine-protein kinase 11
, serine/threonine-protein kinase LKB1
, LKB1 short isoform
, liver kinase B1 homolog
, egg and embryo kinase 1
, serine/threonine-protein kinase XEEK1
, serine/threonine-protein kinase stk11