Browse our LKB1 Proteins (STK11)

Full name:
serine/threonine Kinase 11 Proteins (STK11)
On are 13 serine/threonine Kinase 11 (STK11) Proteins from 6 different suppliers available. Additionally we are shipping LKB1 Antibodies (352) and LKB1 Kits (22) and many more products for this protein. A total of 413 LKB1 products are currently listed.
AA408040, hLKB1, Lkb1, mLKB1, Par-4, PJS, R75140, Stk11, wu:fj61a05, xeek1, zgc:110180
list all proteins Gene Name GeneID UniProt
STK11 6794 Q15831
STK11 20869 Q9WTK7
STK11 314621  

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LKB1 Proteins (STK11) by Origin

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Human serine/threonine Kinase 11 (STK11) interaction partners

  1. Low LKB1 expression is associated with HPV-associated cervical cancer progression.

  2. Mutations in TP53 and STK11 also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 with suppression of immune surveillance. These findings illustrate the remarkably distinct ways through which tumor suppressor mutations may contribute to heterogeneity in KRAS-mutant tumor biology.

  3. Studies indicate that the serine-threonine kinase 11 (Peutz-Jeghers syndrome) LKB1 gene is somatically mutated in female reproductive tract cancers.

  4. Our results indicate that HPV16 E6/E7 indirectly upregulated the expression of VEGF by inhibition of liver kinase B1 expression and upregulation of hypoxia-inducible factor 2alpha expression,thus propose a human papillomavirus-liver kinase B1-hypoxia-inducible factor 2A-vascular endothelial growth factor axis for the tumorigenesis of lung cancer

  5. The expression of LKB1 is down-regulated in most of the lung cell lines.

  6. Genetic variability at STK11 locus is associated with coronary artery disease risk in type 2 diabetes in the Chinese population.

  7. pregulation of PTEN and LKB1 in concert with negative or low levels of activated Akt (show AKT1 Proteins), mTOR (show FRAP1 Proteins) and S6 indicates that PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway may not play a significant role in pathogenesis of leiomyoma.

  8. Data provide evidence for three novel mutations and three recurrent mutations in STK11 were identified in Chinese families with Peutz-Jeghers syndrome, which further broaden the mutation spectrum of STK11.

  9. The mutation detection rate for the LKB1 gene was 85.7% in our Chinese familial Peutz-Jeghers Syndrome and 63.2% in all Chinese Peutz-Jeghers Syndrome patients. The amplification and sequencing results of the flanking sequences presented 3 kinds of polymorphisms in introns of LKB1 gene: (c.374+24G>T, c.464+47_48inGGGGGCC, and c.920+7G>C).

  10. STK11 mutation in gastric in gastric-type endocervical adenocarcinoma is associated with worse prognosis.

Mouse (Murine) serine/threonine Kinase 11 (STK11) interaction partners

  1. this study identified the molecular mechanism of increased angiogenesis and tumor growth with LKB1 deficiency

  2. These results suggest that although physiologic LKB1 expression exerts a potent pro-survival effect in lymphocytes, LKB1 inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.

  3. These results suggest that the LKB1-AMPK (show PRKAA1 Proteins)-FoxO1 (show FOXO1 Proteins) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.

  4. Lkb1 activates the Notch (show NOTCH1 Proteins) signaling pathway, which subsequently increases Pax7 (show PAX7 Proteins) expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch (show NOTCH1 Proteins) activation through AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathway in myoblasts.

  5. mitochondrial dysfunction triggers LKB1-mediated AMPK (show PRKAA1 Proteins) activation, which stimulates Sirt2 (show SIRT2 Proteins) phosphorylation, leading to activation of mTOR (show FRAP1 Proteins)-RAPTOR (show RPTOR Proteins) and Glut1 (show SLC2A1 Proteins)-mediated glucose uptake.

  6. these data demonstrated that LKB1/AMPK (show PRKAA1 Proteins) signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1/AMPK (show PRKAA1 Proteins) signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.

  7. Data show that the serine/threonine kinase (show CDK4 Proteins) LKB1 regulates mitochondrial calcium uniporter (MCU (show MCU Proteins))-expression, mitochondria-dependent Ca2 (show CA2 Proteins)+ clearance, and thereby, presynaptic release properties.

  8. LKB1 deficiency in LKB1(Pax2 (show PAX2 Proteins)) CKO mice disrupted hair cell planar polarity during embryonic development. The results suggest that LKB1 is required in planar cell polarity formation in cochlear hair cells in mice.

  9. silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory cephalic neural crest cells from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects

  10. LKB1 complex proteins have a role in myofilament function and myocellular "energy" sensing in the heart

Zebrafish serine/threonine Kinase 11 (STK11) interaction partners

  1. inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (show PDK2 Proteins) expression and inactivates pyruvate dehydrogenase (show PDK2 Proteins) complex by increasing phosphorylation of pyruvate dehydrogenase (show PDK2 Proteins).

  2. A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.

  3. Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.

Pig (Porcine) serine/threonine Kinase 11 (STK11) interaction partners

  1. Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.

LKB1 (STK11) Protein Profile

Protein Summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with LKB1 (STK11)

  • serine/threonine kinase 11 (STK11)
  • serine/threonine kinase 11 (stk11)
  • polarization-related protein LKB1 (lkb1)
  • serine/threonine kinase 11 (Stk11)
  • AA408040 protein
  • hLKB1 protein
  • Lkb1 protein
  • mLKB1 protein
  • Par-4 protein
  • PJS protein
  • R75140 protein
  • Stk11 protein
  • wu:fj61a05 protein
  • xeek1 protein
  • zgc:110180 protein

Protein level used designations for STK11

serine/threonine protein kinase 11 , serine/threonine kinase 11 (Peutz-Jeghers syndrome) , GLEAN_12166 , Serine/threonine-protein kinase 11 , serine/threonine-protein kinase STK11 , serine/threonine kinase 11 , serine/threonine-protein kinase 11-like , liver kinase B1 , polarization-related protein LKB1 , renal carcinoma antigen NY-REN-19 , serine/threonine-protein kinase 11 , serine/threonine-protein kinase LKB1 , LKB1 short isoform , liver kinase B1 homolog , lkb1 , egg and embryo kinase 1 , serine/threonine-protein kinase XEEK1 , serine/threonine-protein kinase stk11

468641 Pan troglodytes
549287 Xenopus (Silurana) tropicalis
662493 Tribolium castaneum
705686 Macaca mulatta
100022246 Monodelphis domestica
100055913 Equus caballus
100460337 Pongo abelii
100477412 Ailuropoda melanoleuca
6794 Homo sapiens
20869 Mus musculus
550537 Danio rerio
399100 Xenopus laevis
420105 Gallus gallus
485088 Canis lupus familiaris
515245 Bos taurus
314621 Rattus norvegicus
100512213 Sus scrofa
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