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Browse our LKB1 Proteins (STK11)

Full name:
serine/threonine Kinase 11 Proteins (STK11)
On www.antibodies-online.com are 8 serine/threonine Kinase 11 (STK11) Proteins from 5 different suppliers available. Additionally we are shipping LKB1 Antibodies (325) and LKB1 Kits (18) and many more products for this protein. A total of 377 LKB1 products are currently listed.
Synonyms:
AA408040, hLKB1, Lkb1, mLKB1, Par-4, PJS, R75140, Stk11, wu:fj61a05, xeek1, zgc:110180
list all proteins Gene Name GeneID UniProt
STK11 6794 Q15831
STK11 20869 Q9WTK7
STK11 314621  

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LKB1 Proteins (STK11) by Origin

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More Proteins for LKB1 Interaction Partners

Human serine/threonine Kinase 11 (STK11) interaction partners

  1. Significant downregulation of LKB1 and PTEN mRNA expression levels were detected in tumour tissues compared to non-cancerous tissues.

  2. This is the fi rst (show SLC22A12 Proteins) report of clinical overlap in individuals with PCOS and PJS, even though some individuals with PCOS show a polymorphism in STK11.

  3. The present study aimed to compare the expression of liver kinase B1 (LKB1) in prostate cancer (PCa (show FLVCR1 Proteins)) tissues and the paired adjacent tissues, then to evaluate the statistical relationship between LKB1 expression and prognosis of PCa (show FLVCR1 Proteins) patients.

  4. This report details the first four reported cases of somatic mosaicism for STK11 associated with Peutz-Jeghers syndrome

  5. Results demonstrate a direct impact of altered LKB1-AMPK (show PRKAA1 Proteins) signalling function in EOC. In addition, this is the first evidence in cancer cells demonstrating a pro-survival function for LKB1, a kinase traditionally thought to act as a tumour suppressor.

  6. the expression of LKB1 was reduced in the gastric cancer tissues

  7. We found seven novel and four recurrent STK11 gene mutations in Chinese children with PJS.

  8. Transfection with eukaryotic plasmid for the simultaneous expression of GRIM19 (show NDUFA13 Proteins) and LKB1 more effectively suppressed the growth of breast cancer in vitro and in vivo, and may therefore have therapeutic potential for the treatment of human breast cancer.

  9. results suggest that decreased LKB1 expression in patients with solid tumors might be related to poor prognosis and serve as a potential predictive marker of poor clinicopathological prognostic factors

  10. Data show that honokiol (HNK) increases microRNA miR (show MLXIP Proteins)-34a in liver kinase B1 (LKB1)-dependent manner.

Mouse (Murine) serine/threonine Kinase 11 (STK11) interaction partners

  1. Partial deficiency of cardiac LKB1 promotes the adverse effects of a high-fat, high-sucrose diet on the myocardium, leading to worsening of diastolic function and the de novo appearance of systolic dysfunction.

  2. Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.

  3. We proposed that LKB1 regulates cerebellar development by controlling GCPs proliferation through Shh (show SHH Proteins) signalling during cerebellar development.

  4. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

  5. LKB1 promotes maturation of bile ducts during biliary morphogenesis.LKB1 and Notch (show NOTCH1 Proteins) share a common genetic program in the liver, and regulate bile duct morphogenesis.

  6. STK11/LKB1-inactivating mutations were associated with reduced expression of PD-1 (show PDCD1 Proteins) ligand PD-L1 (show CD274 Proteins) in mouse and patient tumors as well as in tumor-derived cell lines.

  7. activation of AKT (show AKT1 Proteins) and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression.

  8. we show that loss of LKB1 in renal tubular epithelial cells has an important role in kidney disease development by influencing intracellular metabolism

  9. The LKB1 K178R SUMO mutant had defective AMPK (show PRKAA1 Proteins) signaling and mitochondrial function, inducing death in energy-deprived cells.

  10. data indicates that LKB1 is required for the development and maintenance of stereocilia in the inner ear.

Zebrafish serine/threonine Kinase 11 (STK11) interaction partners

  1. A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.

  2. Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.

Pig (Porcine) serine/threonine Kinase 11 (STK11) interaction partners

  1. Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.

LKB1 (STK11) Protein Profile

Protein Summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with LKB1 (STK11)

  • serine/threonine kinase 11 (STK11)
  • serine/threonine kinase 11 (stk11)
  • polarization-related protein LKB1 (lkb1)
  • serine/threonine kinase 11 (Stk11)
  • AA408040 protein
  • hLKB1 protein
  • Lkb1 protein
  • mLKB1 protein
  • Par-4 protein
  • PJS protein
  • R75140 protein
  • Stk11 protein
  • wu:fj61a05 protein
  • xeek1 protein
  • zgc:110180 protein

Protein level used designations for STK11

serine/threonine protein kinase 11 , serine/threonine kinase 11 (Peutz-Jeghers syndrome) , GLEAN_12166 , Serine/threonine-protein kinase 11 , serine/threonine-protein kinase STK11 , serine/threonine kinase 11 , serine/threonine-protein kinase 11-like , liver kinase B1 , polarization-related protein LKB1 , renal carcinoma antigen NY-REN-19 , serine/threonine-protein kinase 11 , serine/threonine-protein kinase LKB1 , LKB1 short isoform , liver kinase B1 homolog , lkb1 , egg and embryo kinase 1 , serine/threonine-protein kinase XEEK1 , serine/threonine-protein kinase stk11

GENE ID SPECIES
468641 Pan troglodytes
549287 Xenopus (Silurana) tropicalis
662493 Tribolium castaneum
705686 Macaca mulatta
100022246 Monodelphis domestica
100055913 Equus caballus
100460337 Pongo abelii
100477412 Ailuropoda melanoleuca
6794 Homo sapiens
20869 Mus musculus
550537 Danio rerio
399100 Xenopus laevis
420105 Gallus gallus
485088 Canis lupus familiaris
515245 Bos taurus
314621 Rattus norvegicus
100512213 Sus scrofa
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