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Browse our SLC2A4 Proteins (SLC2A4)

Full name:
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 Proteins (SLC2A4)
On are 6 Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) Proteins from 4 different suppliers available. Additionally we are shipping SLC2A4 Antibodies (214) and SLC2A4 Kits (44) and many more products for this protein. A total of 274 SLC2A4 products are currently listed.
Glut-4, glut4, slc2a4
list all proteins Gene Name GeneID UniProt
SLC2A4 6517 P14672
SLC2A4 20528 P14142
SLC2A4 25139 P19357

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SLC2A4 Proteins (SLC2A4) by Origin

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More Proteins for SLC2A4 Interaction Partners

Horse (Equine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

  1. Insulin (show INS Proteins) resistance was associated with a significantly reduced total GLUT4 content in omental adipose tissue, without a change in content in other visceral or subcutaneous adipose sites.

  2. There was a significant difference when pooled means for Glut-4 expression in muscle compared with adipose tissue from different anatomical sites.

Human Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

  1. These results suggest that the initial event caused by overnutrition may be oxidative stress, which produces insulin (show INS Proteins) resistance, at least in part, via carbonylation and oxidation-induced inactivation of GLUT4.

  2. A single bout of exercise elicited similar GLUT4 translocation in skeletal muscle of PCOS and Controls. The absence of impairment in GLUT4 translocation suggests that PCOS patients with obesity and insulin (show INS Proteins) resistance may benefit from exercise training.

  3. SLC2A4 gene expression level was slightly lower within type 2 diabetic patients in both type of tissues. Furthermore, the negative correlation between SLC2A4 gene expression level in visceral adipose tissue and BMI has been noticed

  4. Leptin (show LEP Proteins) at concentrations used in the study does not change glucose transport into lymphocytes and seems to have no influence on the expression of GLUT1 (show SLC2A1 Proteins), GLUT3 (show SLC2A3 Proteins), GLUT4 and and leptin (show LEP Proteins) receptors

  5. GIV directly and constitutively binds the exocyst complex subunit Exo-70 (show EXOC7 Proteins) and also associates with GLUT4-storage vesicles (GSVs) exclusively upon insulin (show INS Proteins) stimulation.

  6. Data suggest that down-regulation of GLUT4 expression in white/beige/brown adipocytes is associated with impaired glucose uptake/metabolism, impaired adipogenesis, and insulin (show INS Proteins) resistance. [REVIEW]

  7. Study of the molecular mechanisms of GLUT4 regulation in adipocytes.

  8. These results indicate that T2DM patients may have a high level miR (show MLXIP Proteins)-199a that reduce GLUT4 expression and contribute to the insulin (show INS Proteins) resistance.

  9. Role of the guanine nucleotide exchange factor (show RASGRF1 Proteins) in Akt2 (show AKT2 Proteins)-mediated plasma membrane translocation of GLUT4 in insulin (show INS Proteins)-stimulated skeletal muscle.

  10. Therapeutic concentrations of cyclosporine and tacrolimus can inhibit glucose uptake independent of insulin (show INS Proteins) signaling by removing GLUT4 from the cell surface via an increased rate of endocytosis.

Pig (Porcine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

  1. TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 showed altered expression in some tissues in pre-diabetic pigs.

  2. analysis of time- and breed-specific expression patterns of GLUT2 (show SLC2A2 Proteins) and GLUT4, which highlight their potential as candidate genes for assessing adipose deposition and muscle development in pigs

  3. Chronic elevated calcium blocks AMPK (show PRKAA1 Proteins)-induced GLUT-4 expression in skeletal muscle.

Mouse (Murine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

  1. Leucine significantly increased PPARbeta (show PPARD Proteins)/delta expression with enhanced glucose transporter 4 (GLUT4) content and glucose uptake in myotubes.

  2. Study found that knockdown of Prep1 gene expression affects adipogenic differentiation and results in significant increase in the insulin (show INS Proteins)-sensitive glucose carrier Glut4 gene expression

  3. Data suggest that trans-cinnamaldehyde, a dietary flavoring agent with suspected hypoglycemic effects, stimulates mitochondrial biogenesis in muscle fibers through up-regulation of gene expression of Pgc1a (PPARgamma (show PPARG Proteins) coactivator 1 alpha) and Glut4.

  4. alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta (show PKCd Proteins)-mediated GLUT (show SLC1A3 Proteins) translocation that may be specific to the alpha(1A)-AR subtype.

  5. CD2AP (show Cd2ap Proteins) forms a complex with GGA2 (show GGA2 Proteins), a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP (show Cd2ap Proteins) in this process.

  6. Study shows that high-intensity training was more effective for increasing GLUT4 content and glycaemia reduction in insulin (show INS Proteins)-resistant mice, perhaps because of a higher metabolic demand imposed by this form of exercise.

  7. GLUT-4 and -8 are insulin (show INS Proteins)-sensitive.

  8. Glut4 traffics predominantly through the specialized Rab10 (show RAB10 Proteins)-dependent pathway both before and after insulin (show INS Proteins) stimulation.

  9. Morphological changes and GLUT1 (show SLC2A1 Proteins), GLUT3 (show SLC2A3 Proteins), and GLUT4 expression were evaluated in placentas by immunohistochemical and image analysis and correlated with iAs and arsenical species concentration, which were quantified by atomic absorption spectroscopy

  10. data suggest that insulin (show INS Proteins) stimulates traffic from cellugyrin (show SYNGR2 Proteins)-containing to sortilin (show SORT1 Proteins)-containing membranes, and that cellugyrin (show SYNGR2 Proteins)-containing IGVs provide an insulin (show INS Proteins)-sensitive reservoir to replenish GSVs following insulin (show INS Proteins)-stimulated exocytosis of GLUT4.

Cow (Bovine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

  1. Low GLUT1 (show SLC2A1 Proteins) and GLUT3 (show SLC2A3 Proteins) expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin (show INS Proteins) responsive.

  2. Results of the present study suggest that myostatin (show MSTN Proteins) inhibits the expression of GLUT4 mRNA and that the greater ability of double muscled cattle to produce muscle may be due to their greater sensitivity to insulin (show INS Proteins) and greater use of glucose.

  3. GLUT4 gene expression increased during late lactation.

SLC2A4 Protein Profile

Protein Summary

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).

Alternative names and synonyms associated with SLC2A4

  • solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4)
  • solute carrier family 2 (facilitated glucose transporter), member 4 (Slc2a4)
  • solute carrier family 2 (facilitated glucose transporter), member 4 (slc2a4)
  • solute carrier family 2 (facilitated glucose transporter), member 4 (GLUT4)
  • Glut-4 protein
  • glut4 protein
  • slc2a4 protein

Protein level used designations for SLC2A4

glucose transporter 4 , glucose transporter type 4 , solute carrier family 2, facilitated glucose transporter member 4 , solute carrier family 2 (facilitated glucose transporter), member 4 , solute carrier family 2, facilitated glucose transporter member 4-like , insulin-responsive glucose transporter , GLUT-4 , glucose transporter type 4, insulin-responsive , insulin-responsive glucose transporter type 4 , GT2 , Glucose transporter 4 insuline-responsive , Glucose transporter 4, insuline-responsive , solute carrier family 2 member 4 , solute carrier family 2 , member 4 , Insulin-responsive glucose transporter , GLUT4 , insulin-responsive glucose transporter 4

468443 Pan troglodytes
100033939 Equus caballus
100456448 Pongo abelii
100127021 Felis catus
6517 Homo sapiens
396754 Sus scrofa
20528 Mus musculus
25139 Rattus norvegicus
100037710 Oryctolagus cuniculus
282359 Bos taurus
444033 Xenopus laevis
403673 Canis lupus familiaris
100860891 Capra hircus
442992 Ovis aries
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