Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody

Details for Product No. ABIN108424
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Antigen
Synonyms CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, C85791, Cd31, Pecam
Reactivity
Human
(399), (187), (69), (43), (30), (20), (11), (5), (2), (1)
Host
Mouse
(300), (167), (81), (4), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(59), (46), (32), (19), (10), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(307), (207), (130), (122), (106), (79), (66), (58), (44), (20), (20), (10), (5), (4), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN108424
442.86 $
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Immunogen Monoclonal antibody to PECAM-1 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Ulex Europaeus-agglutinin-I reactive glycoproteins from cultured human umbilical vein endothelial cells isolated by lecitin-affinity chromatography were used as immunogen
Clone CE6
Isotype IgG1
Specificity The antibody reacts with Mr 135 000 PECAM-1 polypeptide from leukocytes and endothelial cells. Detects all endothelial cells in breast. Shows erythroid differentiation in human leukemic cells.
Alternative Name PECAM-1
Background PECAM-1 (CE6) monoclonal antibody against PECAM-1 was produced to characterize human leukemic cells. PECAM-1 is typically an antigen that is shared by both endothelial and distinct hematopoietic cells. It is widely expressed among leukocytes and functions as cell adhesion molecule for these cells. PECAM-1 reactivity can be interpreted as a further evidence for megakaryocytic nature of distinct cell lines has been shown. However, a new useful application for this monoclonal antibody appears to be its very high reactivity against human endothelial cells. A recent review article states that in contrast to other applied endothelial markers, for instance PAL-E monoclonal antibody to endothelial cells and antibodies to factor VIII-related antigen, CE6 monoclonal antibody, reacts with all endothelial cells in human breast.
Research Area Extracellular Matrix
Application Notes No reactivity with paraffin sections. Working dilution in western blotting is at least 1:1000
Restrictions For Research Use only
Storage 4 °C
Supplier Images
anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody Carcinoma of the breast (MAb CE6, PECAM-1)
General Ronnov-Jessen L, Petersen OW, Bissell MJ: "Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction." in: Physiol Rev, Vol. 76, Issue 1, pp. 69-125, 1996 (PubMed).

Tani, Ylänne, Virtanen: "Expression of megakaryocytic and erythroid properties in human leukemic cells." in: Experimental hematology, Vol. 24, Issue 2, pp. 158-68, 1996 (PubMed).

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