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Details for Product No. ABIN1098124

Hyaluronan Synthase 2 (HAS2) (AA 67-170) antibody

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Antigen
Synonyms Has2, DG42, XHas2
Epitope
»Alternatives AA 67-170
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 2 references available
Catalog no. ABIN1098124
Quantity 0.1 mg
Price
396.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human HAS2 (AA 67-170) expressed in E. coli.
Clone 4-00E-07
Isotype IgG1
Purification Purified
Alternative Name HAS2
Background Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by β-1-3 and β-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor mηstasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its AA sequence shows significant homology to glycosaminoglycan synthηse (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
Molecular Weight 63.5 kDa
Gene ID 3037
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/100 - 1/500
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Jokela, Makkonen, Oikari et al.: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." in: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, 2011 (PubMed).

Okuda, Kobayashi, Xia et al.: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." in: Cancer research, Vol. 72, Issue 2, pp. 537-47, 2012 (PubMed).

Alternatives for antigen "Hyaluronan Synthase 2 (HAS2)", type "Antibodies"
Hosts (15), (2)
Reactivities (17), (12), (12), (12), (12), (12)
Applications (10), (8), (5), (5), (3), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (1), (1), (1), (1)
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