Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) antibody

Details for Product No. ABIN1106262
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Antigen
Synonyms CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, CD32a
Reactivity
Dog (Canine), Human, Rhesus Monkey
(131), (10), (6), (6), (2), (1)
Host
Mouse
(72), (69), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Functional Studies (Func), Immunoprecipitation (IP)
(99), (55), (44), (37), (35), (26), (14), (10), (10), (4), (1), (1), (1), (1), (1)
Pubmed 11 references available
Quantity 0.5 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1106262
632.50 $
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Immunogen K562 cell line
Clone AT10
Isotype IgG1
Purification Affinity Chromatography on Protein A
Endotoxin Level Low Endotoxin
Alternative Name CD32 / FcRII-A
Background CD32 antigen is a 40 kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII). The antigen mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets.Synonyms: CDw32, FCG2, FCGR2A, FCGR2A1, Fc-gamma RII-a, Fc-gamma-RIIa, IGFR2, IgG Fc receptor II, Low affinity immunoglobulin gamma Fc region receptor II
Gene ID 2212
NCBI Accession NP_001129691
UniProt P12318
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Background publications Greenman, Tutt, George et al.: "Characterization of a new monoclonal anti-Fc gamma RII antibody, AT10, and its incorporation into a bispecific F(ab')2 derivative for recruitment of cytotoxic effectors." in: Molecular immunology, Vol. 28, Issue 11, pp. 1243-54, 1992 (PubMed).

Van Den Herik-Oudijk, Westerdaal, Henriquez et al.: "Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 2, pp. 574-85, 1994 (PubMed).

Lilliehöök, Johannisson, Håkansson: "Expression of adhesion and Fcgamma-receptors on canine blood eosinophils and neutrophils studied by anti-human monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 61, Issue 2-4, pp. 181-93, 1998 (PubMed).

Sims, Ettinger, Shirota et al.: "Identification and characterization of circulating human transitional B cells." in: Blood, Vol. 105, Issue 11, pp. 4390-8, 2005 (PubMed).

Benitez-Ribas, Adema, Winkels et al.: "Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake." in: The Journal of experimental medicine, Vol. 203, Issue 7, pp. 1629-35, 2006 (PubMed).

Dutertre, Bonnin-Gélizé, Pulford et al.: "A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function." in: Journal of leukocyte biology, Vol. 84, Issue 6, pp. 1511-20, 2008 (PubMed).

Khan, Kim, Kim: "Synthesis and control of physical properties of titania nanoparticles as a function of synthetic parameters." in: Journal of nanoscience and nanotechnology, Vol. 8, Issue 9, pp. 4738-42, 2008 (PubMed).

Devriendt, Verdonck, Summerfield et al.: "Targeting of Escherichia coli F4 fimbriae to Fcgamma receptors enhances the maturation of porcine dendritic cells." in: Veterinary immunology and immunopathology, Vol. 135, Issue 3-4, pp. 188-98, 2010 (PubMed).

Santer, Hall, George et al.: "C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 8, pp. 4738-49, 2010 (PubMed).

Araújo, de Andrade, Sathler-Avelar et al.: "Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis." in: Veterinary immunology and immunopathology, Vol. 141, Issue 1-2, pp. 64-75, 2011 (PubMed).

Zhao, van Beek, Schornagel et al.: "CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 45, pp. 18342-7, 2011 (PubMed).

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