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CD48 Molecule (CD48) antibody

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Synonyms AI449234, AW610730, BCM1, BLAST, BLAST-1, BLAST1, Bcm-1, MEM-102, SLAMF2, Sgp-60, hCD48, mCD48
Human, Primate
(168), (105), (37), (8), (5), (5), (1)
(154), (53), (42), (36), (10), (1)
Clonality (Clone)
Monoclonal ()
(47), (46), (19), (15), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(216), (79), (47), (30), (28), (25), (21), (13), (8), (7), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 8 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Raji human Burkitt's lymphoma cell line
Clone MEM-102
Isotype IgG1
Specificity The antibody reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells, it is negative on granulocytes, platelets and erythrocytes.
Purification Protein-A affinity chromatography
Purity > 95 % pure (by SDS-PAGE)
Alternative Name CD48 (CD48 Antibody Abstract)
Background CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, which includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of their family, thus mediate homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases.Synonyms: B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, Leukocyte antigen MEM-102, MEM-102, TCT.1
Gene ID 962
NCBI Accession NP_001769
UniProt P09326
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Munitz, Bachelet, Eliashar et al.: "CD48 is an allergen and IL-3-induced activation molecule on eosinophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 77-83, 2006 (PubMed).

Assarsson, Kambayashi, Persson et al.: "2B4/CD48-mediated regulation of lymphocyte activation and function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 4, pp. 2045-9, 2005 (PubMed).

Mathew, Kumaresan, Lee et al.: "Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 2, pp. 1005-13, 2005 (PubMed).

Lee, Forman, McNerney et al.: "Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions." in: Blood, Vol. 107, Issue 8, pp. 3181-8, 2006 (PubMed).

Angelisová, Drbal, Horejsí et al.: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, 1999 (PubMed).

Stulnig, Berger, Sigmund et al.: "Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, 1997 (PubMed).

Bazil, Stefanová, Hilgert et al.: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." in: Folia biologica, Vol. 35, Issue 5, pp. 289-97, 1990 (PubMed).

Korínek, Stefanová, Angelisová et al.: "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1." in: Immunogenetics, Vol. 33, Issue 2, pp. 108-12, 1991 (PubMed).

Catalog No. ABIN1106419
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