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CD48 Molecule (CD48) antibody

Details for Product No. ABIN1106419
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Antigen
Synonyms BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102, Bcm-1, Sgp-60, BLAST-1, AI449234, AW610730
Reactivity
Human, Primate
(96), (81), (41), (12), (12), (5), (5), (3)
Host
Mouse
(98), (35), (33), (26), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(30), (24), (16), (10), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(144), (52), (29), (23), (18), (10), (7), (6), (5), (3), (3), (3)
Pubmed 8 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN1106419
308.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Raji human Burkitt's lymphoma cell line
Clone MEM-102
Isotype IgG1
Specificity The antibody reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells, it is negative on granulocytes, platelets and erythrocytes.
Purification Protein-A affinity chromatography
Purity > 95% pure (by SDS-PAGE)
Alternative Name CD48
Background CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, which includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of their family, thus mediate homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases.
Alternate names: B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, Leukocyte antigen MEM-102, MEM-102, TCT.1
Gene ID 962
NCBI Accession NP_001769.2
UniProt P09326
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Korínek, Stefanová, Angelisová et al.: "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1." in: Immunogenetics, Vol. 33, Issue 2, pp. 108-12, 1991 (PubMed).

Bazil, Stefanová, Hilgert et al.: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." in: Folia biologica, Vol. 35, Issue 5, pp. 289-97, 1990 (PubMed).

Stulnig, Berger, Sigmund et al.: "Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, 1997 (PubMed).

Angelisová, Drbal, Horejsí et al.: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, 1999 (PubMed).

Lee, Forman, McNerney et al.: "Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions." in: Blood, Vol. 107, Issue 8, pp. 3181-8, 2006 (PubMed).

Mathew, Kumaresan, Lee et al.: "Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 2, pp. 1005-13, 2005 (PubMed).

Assarsson, Kambayashi, Persson et al.: "2B4/CD48-mediated regulation of lymphocyte activation and function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 4, pp. 2045-9, 2005 (PubMed).

Munitz, Bachelet, Eliashar et al.: "CD48 is an allergen and IL-3-induced activation molecule on eosinophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 77-83, 2006 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1106419
308.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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