MARCO antibody (AA 420-431)

Catalog No. ABIN1108157

Product Details anti-MARCO Antibody

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Binding Specificity: AA 420-431

Reactivity: Human, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This MARCO antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.

No Cross-Reactivity: Chicken

Cross-Reactivity (Details): Species reactivity (tested):Human, Bovine.

Purification: Protein G Chromatography

Immunogen: Human alveolar macrophages

Clone: PLK-1

Isotype: IgG3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for MARCO

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Alternative Name: MARCO (MARCO Products)

Synonyms: AI323439 antibody, Ly112 antibody, Scara2 antibody, SCARA2 antibody, macrophage receptor with collagenous structure antibody, MARCO antibody, Marco antibody

Background: The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure

Gene ID: 8685

NCBI Accession: NP_006761

UniProt: Q9UEW3

Pathways: Activation of Innate immune Response