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Macrophage Receptor with Collagenous Structure (MARCO) (AA 420-431) antibody

Details for Product No. ABIN1108157
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Antigen
Synonyms SCARA2, Ly112, Scara2, AI323439
Epitope
AA 420-431
(9), (8), (3)
Reactivity
Cow (Bovine), Human
(35), (31), (17), (17), (17), (17), (4)
Host
Mouse
(31), (18), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
(29), (19), (15), (11), (9), (7), (6), (5), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN1108157
621.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human alveolar macrophages
Clone PLK-1
Isotype IgG3
Specificity This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.
Purification Protein G Chromatography
Alternative Name MARCO
Background The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it’s expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.
Alternate names: Scavenger Receptor, macrophage receptor with collagenous structure
Gene ID 8685
NCBI Accession NP_006761.1
UniProt Q9UEW3
Research Area Receptors
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, 0.1% BSA
Storage 4 °C
Storage Comment Store undiluted at 2-8°C.
Expiry Date 12 months
Background publications Palecanda, Kobzik: "Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors." in: Current molecular medicine, Vol. 1, Issue 5, pp. 589-95, 2002 (PubMed).

Bunn, Kobzik, Grigg: "MARCO expression on pediatric alveolar macrophages." in: Cytometry. Part B, Clinical cytometry, Vol. 60, Issue 1, pp. 54-6, 2004 (PubMed).

Arredouani, Palecanda, Koziel et al.: "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 9, pp. 6058-64, 2005 (PubMed).

Martens, Kzhyshkowska, Falkowski-Hansen et al.: "Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis." in: The Journal of pathology, Vol. 208, Issue 4, pp. 574-89, 2006 (PubMed).

Hamilton, Thakur, Mayfair et al.: "MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34218-26, 2006 (PubMed).

Ghasemi-Varnamkhasti, Mohtasebi, Siadat et al.: "Meat quality assessment by electronic nose (machine olfaction technology)." in: Sensors (Basel, Switzerland), Vol. 9, Issue 8, pp. 6058-83, 2012 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1108157
621.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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