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Macrophage Receptor with Collagenous Structure (MARCO) (AA 420-431) antibody

Details for Product No. ABIN1108157, Supplier: Log in to see
Antigen
  • AI323439
  • Ly112
  • Scara2
  • SCARA2
Epitope
AA 420-431
18
9
9
4
1
Reactivity
Cow (Bovine), Human
33
30
4
1
Host
Mouse
32
26
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
16
9
2
2
2
2
Application
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
55
31
18
16
12
7
5
5
2
2
Supplier
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Immunogen Human alveolar macrophages
Clone PLK-1
Isotype IgG3
Specificity This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.
No Cross-Reactivity Chicken
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine.
Purification Protein G Chromatography
Alternative Name MARCO (MARCO Antibody Abstract)
Background The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure
Gene ID 8685
NCBI Accession NP_006761
UniProt Q9UEW3
Research Area Receptors
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % BSA
Storage 4 °C
Storage Comment Store undiluted at 2-8 °C.
Background publications Ghasemi-Varnamkhasti, Mohtasebi, Siadat et al.: "Meat quality assessment by electronic nose (machine olfaction technology)." in: Sensors (Basel, Switzerland), Vol. 9, Issue 8, pp. 6058-83, 2012 (PubMed).

Hamilton, Thakur, Mayfair et al.: "MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34218-26, 2006 (PubMed).

Martens, Kzhyshkowska, Falkowski-Hansen et al.: "Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis." in: The Journal of pathology, Vol. 208, Issue 4, pp. 574-89, 2006 (PubMed).

Arredouani, Palecanda, Koziel et al.: "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 9, pp. 6058-64, 2005 (PubMed).

Bunn, Kobzik, Grigg: "MARCO expression on pediatric alveolar macrophages." in: Cytometry. Part B, Clinical cytometry, Vol. 60, Issue 1, pp. 54-6, 2004 (PubMed).

Palecanda, Kobzik: "Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors." in: Current molecular medicine, Vol. 1, Issue 5, pp. 589-95, 2002 (PubMed).