Zinc Finger and BTB Domain Containing 4 (ZBTB4) antibody

Details for Product No. ABIN1109539
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Synonyms 2310026P19Rik, 9230111I22Rik, RP23-422L16.16, mKIAA1538, KAISO-L1, ZNF903
(33), (20), (13), (13), (12), (12)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
(24), (16), (12), (10), (3)
Pubmed 2 references available
Catalog no. ABIN1109539
Quantity 0.1 mg
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Immunogen Synthetic peptide derived from an internal domain of Human ZBTB4
Specificity This antibody reacts with 105 kDa ZBTB4 protein.
Purification Affinity Chromatography on Protein A
Alternative Name ZBTB4
Background The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.
Alternate names: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4
Gene ID 57659
NCBI Accession NP_001122305.1
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore in distilled water.
Buffer 0.1M Tris, 0.1M Glycine, 2% Sucrose
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Nguyen, Yamada, Schultz et al.: "Assessment of sera for chromatin-immunoprecipitation." in: BioTechniques, Vol. 44, Issue 1, pp. 66, 68, 2008 (PubMed).

Weber, Marquardt, Elzi et al.: "Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation." in: The EMBO journal, Vol. 27, Issue 11, pp. 1563-74, 2008 (PubMed).

Hosts (33)
Reactivities (33), (20), (13), (13), (12), (12)
Applications (24), (16), (12), (10), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (3), (1), (1)
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