8-Hydroxyguanosine (8-OHDG) antibody

Details for Product No. ABIN111330
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Antigen
Reactivity
Chemical
(30), (1), (1), (1), (1)
Host
Mouse
(17), (14)
Clonality (Clone)
Monoclonal ()
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
(28), (15), (11), (4), (3), (2), (2), (2), (2), (2)
Pubmed 4 references available
Catalog no. ABIN111330
Quantity 0.1 mg
Price
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Immunogen 8-Hydroxyguanosine (OH8G)-BSA and -casein conjugates.
Clone 15A3
Isotype IgG2a
Specificity This antibody recognizes 8-hydroxy-2'-deoxyguanosine (OH8dG), 8-hydroxyguanine (OH8G), and 8-hydroxyguanosine (OH8G). These are markers of oxidative damage to DNA and RNA.
Purification Protein G Chromatography.
Alternative Name 8-Hydroxy-Guanosine / 8-OHG
Background 8 Hydroxyguanosine (80G) is a modified base which occurs in DNA as a result of oxidative stress. 8 Hydroxy-2'deoxyguanosine (8OHdG) has become a sensitive marker of oxidative damage in cellular DNA and has been reported to be excreted in the urine. Levels of 8OHdG have been shown to increase on exposure to ionizing radiation and tobacco smoke.
Alternate names: 8-Hydroxy-2'-deoxyguanosine, 8-Hydroxyguanine, 8-Hydroxyguanosine, 8-OFdG, 8-OHG, 8OG, 8OHG, 8OHdG
Application Notes Suitable for use in ELISA and Immunohistochemistry (PLP-fixed sections) to detect themarkers of oxidative damage to DNA and RNA. May also be used on Immunoaffinity columns to isolate oxidative DNA damage adductsfrom biological fluids. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL (OD 280 nm)
Buffer TBS, pH 7.4 with 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Expiry Date 12 months
Background publications Nunomura, Perry, Pappolla et al.: "RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 6, pp. 1959-64, 1999 (PubMed).

Cui, Holmes, Liu: "Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia." in: Journal of neurochemistry, Vol. 73, Issue 3, pp. 1164-74, 1999 (PubMed).

Salganik, Albright, Rodgers et al.: "Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice." in: Carcinogenesis, Vol. 21, Issue 5, pp. 909-14, 2000 (PubMed).

General Park, Shigenaga, Degan et al.: "Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 8, pp. 3375-9, 1992 (PubMed).

Hosts (17), (14)
Reactivities (30), (1), (1), (1), (1)
Applications (28), (15), (11), (4), (3), (2), (2), (2), (2), (2)
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