K-Cadherin (CDH6) (Extracellular Domain) antibody

Details for Product No. ABIN112365
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms KCAD, K-cadherin, cad6, cadherin-6, CAD6, c-cad6B
Epitope
Extracellular Domain
(10), (9), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(51), (21), (17), (17)
Host
Mouse
(40), (10), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(35), (27), (20), (19), (14), (9), (6), (5), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN112365
489.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Affinity purified extracellular domain of human cadherin-6-GST fusion protein
Clone 2B6
Isotype IgG1
Specificity Clone 2B6 recognizes the extracellular domain of cadherin-6.
Purification Purified
Alternative Name Cadherin-6
Background Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+- dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
Alternate names: CDH6, Cadherin K, K-Cadherin, Kidney cadherin
Gene ID 1004
NCBI Accession NP_004923
UniProt P55285
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Immunoblotting (1: 25 - 1: 250). Immunocytochemistry. Immunohistochemistry on frozen sections when using a PBS buffer containing 0.1 mMCaCl2 and 0.1 mM MgCl2. Recommended range is 1: 25 - 1: 50 for immunohistochemistry with avidin-biotinylatedhorseradish peroxidase complex (ABC) as detection reagent. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.09% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Shimazui, Oosterwijk, Akaza et al.: "Expression of cadherin-6 as a novel diagnostic tool to predict prognosis of patients with E-cadherin-absent renal cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 4, Issue 10, pp. 2419-24, 1998 (PubMed).

Shimazui, Oosterwijk-Wakka, Akaza et al.: "Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma." in: European urology, Vol. 38, Issue 3, pp. 331-8, 2000 (PubMed).

Validation Images
Did you look for something else?
back to top