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Details for Product No. ABIN112373

Integrin, alpha 6 (ITGA6) (N-Term), (Isoform 6B) antibody

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Antigen
Synonyms CD49f, ITGA6B, VLA-6, 5033401O05Rik, AI115430, Cd49f, inta6, ITGA6, im:6897425, itga6, si:dkey-32o22.1, wu:fb80g02, LOC100221694
Epitope
»Alternatives N-Term, Isoform 6B
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN112373
Quantity 0.1 mg
Price
412.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen 6B4 is a mouse monoclonal IgG1, k antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a synthetic peptide corresponding to a 34 amino acid stretch in the cytoplasmic domain of integrin a6B including an appending N-terminal Cysteine coupled to keyhole limpet hemocyanin.
Sequence CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK
Clone 6B4
Isotype IgG1
Specificity It recognizes specifically the cytoplasmic domain of integrin subunit alpha-6B. 6B4 stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands. A broad species reactivity is expected because of the conserved nature of the epitope.
Purification Purified
Alternative Name CD49f / ITGA6
Background Integrins are a family of heterodimeric membrane glycoproteins consisting of non- covalently associated a and b subunits. More than 18 a and 8 b subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits a3 and a6, two cytoplasmic variants, A and B, have been identified.
Alternate names: CD49 antigen-like family member F, Integrin alpha-6, VLA-6, VLA6
Gene ID 3655
NCBI Accession NP_000201
UniProt P23229
Application Notes Suitable for Immunoblotting, Immunocytochemistry, Immunohistochemistry on frozensections. Recommended dilutions: 1/50-1/100 for Flow cytometry, and for Immunohistochemistrywith avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and1/100-1/500 for Immunoblotting applications. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the lyophilized antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. When reconstituted the antibody is stable for one month at 2-8°C.
Expiry Date 12 months
Background publications Hogervorst, Admiraal, Niessen et al.: "Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit." in: The Journal of cell biology, Vol. 121, Issue 1, pp. 179-91, 1993 (PubMed).

Alternatives for antigen "Integrin, alpha 6 (ITGA6)", type "Antibodies"
Hosts (70), (55), (42), (1)
Reactivities (147), (48), (21), (19), (15), (14), (14), (13), (4), (2)
Applications (104), (58), (32), (28), (26), (25), (21), (20), (11), (11), (10), (4), (2), (2)
Conjugates (21), (13), (11), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (4), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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