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Gastrin (GAST) antibody

Antigen

Gastrin (GAST)

Synonyms GAS, Gas, PPG34, GAST, CCKBR, CCK-B, CCK-BR, CCK2-R
Clonality Polyclonal
Host
Alternatives

Rabbit

Reactivity
Alternatives

Human

Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
2 references available
Catalog no. ABIN115354
Quantity
Price 363.00 $   Plus shipping costs $45.00
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Additional Information

Alternative name Gastrin
UniProt P01350
Immunogen Recombinant Gastrin conjugated to KLH.
Cross-Reactivity Human
Description Gastrin is mainly known by its first described role as a gastric acid-hormone but the proteinalso has the ability to promote cellular growth. More recently, gastrin has been suggestedto induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate twodifferent receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinityfor the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has highaffinity for both gastrin and CCK and mediates the acid-secretory as well as theproliferative effects of gastrin.
Characteristics Synonyms: GAST, GAS

Application Details

Application Notes Immunohistochemistry on formalin-fixed paraffin embedded sections: diluted of 1: 50-1: 100 in an ABC method (30 minutes at room temperature)Recommended Positive Control: StomachOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Purification Purified
Buffer containing sodium azide as preservative
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area Cardiovascular, Atherosclerosis, Hormones
Restrictions For Research Use only

Publications

Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 815-8, 1997 (PubMed).

Degli-Esposti, Smolak, Walczak et al.: "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1165-70, 1997 (PubMed).